freakout said:
I'm glad you guys are overjoyed by squeegee's posts. Me too to some extent.
I hate to break it but sebum and immunologically related issues have nothing to do with so-called "androgenetic" factors. Immunologically related issues is only a consequence of sebum issues and/or low blood supply.
But why men only? Sebum became an issue to men because of "masculus pessima". Don't bother looking for it on the net because it's a term I invented. It translates to male lousiness.
Sebum became an issue in men when they cut they hair short and not brush them as often as women do.
THere's nothing 'androgenetic' about sebum issues.
LOL Tell me why acne show up a puberty or bodybuilders are suffering from acne when they overdose some steroids? Btw where did get your gay *** book so I can give the inside to people here? I don't mind spending the cash.
Androgens increase the activity of sebaceous gland in both sexes . Hypertrophic sebaceous glands + colonization of Propionibacterium acnes (P.acnes)= inflammation. Inflammation induce hair grow not androgen..
Bryan ...Here is some interesting studies...
A possible specific receptor for 3-beta-androstanediol in the human sebaceous gland.
Caballero MJ, Carreras E, Mallol J.
Source
Unidad de FarmacologÃa, Facultad de Medicina, Universidad de Barcelona, Reus/Tarragona, Spain.
Abstract
Dihydrotestosterone (DHT) does not seem to be the active specific metabolite of testosterone in hypertrophic sebaceous glands of subjects affected by male pattern baldness (male pattern baldness) and several results indicate that probably 3-beta-androstanediol (beta DIOL) could be an active form of testosterone in those glands. Cytosol and serum from several patients affected by male pattern baldness and subjected to hair autotransplantation, was incubated with both beta DIOL and 3-alpha-androstanediol (alpha DIOL). Binding patterns indicate that alpha DIOL binds to cytosolic proteins probably due to the contaminating sex hormone binding globulin (SHBG), whereas beta DIOL exhibits an atypical binding process in cytosol in the presence of high concentrations of non radioactive beta DIOL. This binding increases progressively up to 2 pmol/mg protein at the limit solubility conditions for the non radioactive steroid. This pattern is not observed in serum from the same patients, where the binding of beta DIOL is typically restricted to the SHBG. These results strongly suggest the existence of a specific beta DIOL-binding protein in the hypertrophic sebaceous glands and explain the lack of specific receptor for DHT in these tissues.
Regional scalp differences of the androgenic metabolic pattern in subjects affected by male pattern baldness.
Puerto AM, Mallol J.
Source
Unidad de FarmacologÃa, Facultad de Medicina, Universidad de Barcelona, Reus/Tarragona, Spain.
Abstract
Regional differences in the androgen metabolism were established in alopecic and non alopecic areas of patients affected by male pattern baldness (male pattern baldness). 5-alpha-reductase (5-alpha-R) activity was measured by the formation of dihydrotestosterone (DHT), using 3H-testosterone as substrate: this activity was higher in the alopecic areas (3.4 pmol/g tissue/h) than in the non alopecic skin (1.5 pmol/g tissue/h). 3-alpha,beta-hydroxysteroid oxoreductase (3-alpha, beta-HO) was studied using 3H-DHT as precursor and measuring the corresponding formed 3-alpha- and 3-beta-androstanediols (alpha DIOL and beta DIOL). The beta DIOL was the predominant metabolite and total 3-alpha, beta-HO activity was higher in alopecic skin (12.4 pmol/g tissue/h) than in non alopecic areas (8.4 pmol/g tissue/h). Also 17, beta-hydroxysteroid oxoreductase was measured using either testosterone or DHT as substrates: androstenedione formed from testosterone was higher in hairy skin (12 pmol/g tissue/h) than in alopecic areas (6 pmol/g tissue/h); androstanedione formed from DHT was also higher in non alopecic areas (8.1 pmol/g tissue/h) than in alopecic skin (2.8 pmol/g tissue/h). The greater formation of beta DIOL in the sebaceous glands-enriched alopecic skin supports the hypothesis for a specific role of this metabolite in the control of the sebaceous activity.
Rev Esp Fisiol. 1993 Mar;49(1):1-5.
Guanylate cyclase activity in male pattern baldness. Stimulating effect of 3-beta-androstanediol.
Puerto AM, Mallol J.
Departamento de Ciencias M?dicas B?sicas, Facultad de Medicina, Universidad de Barcelona, Reus, Spain.
Guanylate cyclase (GC) activity was measured in the cytosolic fraction of sebaceous gland-enriched skin samples obtained from alopecic and non-alopecic areas of subjects affected by male pattern baldness. GC activity was significantly higher in alopecic scalp (7.13 +/- 2.7 pmol/min/mg prot; n = 22) than in non-alopecic samples (3.91 +/- 0.48 pmol/min/mg prot; n = 8). 3-beta-androstanediol was able to increase GC activity up to 15% when added to the incubation medium (1 x 10(-5) M). The regional differences observed should be due to the larger size of the sebaceous glands in alopecic areas. The higher production of dihydrotestosterone and 3-beta-androstanediol in alopecic areas may also contribute to determine the level of GC in scalp skin. The role of second messenger systems in sebaceous glands to understand certain aspects of the action mechanism of androgens is discussed.