cloudsanrain
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I am going to make some topical melatonin with powder an dont no how much melatonin to add to a 2 oz bottle . I am also going add PG an ethanol . anybody hav any idea how much to add ?
What % lotion you want to create ? didn't read the studies, not sure what dose they used.I am going to make some topical melatonin with powder an dont no how much melatonin to add to a 2 oz bottle . I am also going add PG an ethanol . anybody hav any idea how much to add ?
Well.. the study you posted about a topical .0033% solution would be beyond the needs or ability to measure that precise. You would have to have a legit lab scale with enclosed in glass to get an accurate measurement or add 3.3 grams of melatonin into a 100,000 gram batch.What % lotion you want to create ? didn't read the studies, not sure what dose they used.
In your previous post, you said that alcohol based compounds get absorbed systemically and do not stay in the follicles. So should we compound it with a cream? Or better yet maybe get a commercially available liquid formulation and dilute further to the desired concentration? Also, what scales are available to purchase that can measure 50 mg or less? I bought some bimatoprost powder and would like to make a 0.01% solution.For a 2% solution:
Add 1200 mg pure melatonin to the empty 60 ml(2 oz) bottle and fill with ethanol.
https://www.caymanchem.com/pdfs/14427.pdf
The solubility of melatonin in ethanol is approximately 20 mg/ml
I think straight ethanol would be a little hard on the scalp . I was thinking more on the line of a 40% ethanol , 20% PG and a 40% water to a 2oz bottle then add melatomin .For a 2% solution:
Add 1200 mg pure melatonin to the empty 60 ml(2 oz) bottle and fill with ethanol.
https://www.caymanchem.com/pdfs/14427.pdf
The solubility of melatonin in ethanol is approximately 20 mg/ml
That's fine but when you start mixing solvents then the data for how much melatonin you can dissolve becomes worthless. Just dissolve as much as you can into it. The PPG I think will keep it more local longer too.I think straight ethanol would be a little hard on the scalp . I was thinking more on the line of a 40% ethanol , 20% PG and a 40% water to a 2oz bottle then add melatomin .
In your previous post, you said that alcohol based compounds get absorbed systemically and do not stay in the follicles. So should we compound it with a cream? Or better yet maybe get a commercially available liquid formulation and dilute further to the desired concentration? Also, what scales are available to purchase that can measure 50 mg or less? I bought some bimatoprost powder and would like to make a 0.01% solution.
Thank you, everyone, for the suggestions on the scales. I bought one from Amazon and it was useless. I couldn't measure anything so now I have a bag of estriol powder, bimatoprost, and SMI. It would be so much easier if I can just compound the entire thing and have it stable for a long time.
Hi. Do you have a recommendation? I live in the US.Can I suggest that you purchase an available off-the-shelf and cheap topical melatonin product that has worked for me as per the various research studies have concluded, being that it stops hair from shedding.
See my post below.
@OtyMac Do you think that, even if melatonin goes sytemic, the benefits for hair will be evident or not? The pharmacy I use has trichosol and trichofoam in addition to hydroalcoholic solutions. I'm not sure if they have creams available.
Here's the study if anyone is interested... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681103/
looks like it's not available in the US. what strength of melatonin does it have?I use a product called bioglan sleep spray.
It is a homeopathic mixture with a low dose of melatonin, but it works for me.
I just buy it off the shelf from chemists