My Regimen Of Spironolactone, Estradiol And Dutasteride

[Ikarus]

200MG Spironolactone | 2MG Estradiol | 0.5MG Dutasteride

I am currently on this trio of medications but I am considering changing it. I will definately continue taking the dutasteride and spironolactone however I am questioning the use of estradiol. I am thinking of switching to estrogel but I am unsure on which one is safer.

Can people recommend me any ideas?

 

[BigOl'BaldingHead]

Is that your scalp?

 

[BigOl'BaldingHead]

Yeah with such a strong regimen regrowth is expected. I wish you all the luck. Does extreme baldness run in the family?

 

[Derelict]

Why no minoxidil either oral or topical? You may respond great to it, a worthwhile addition.

 

[badhabiz]

200MG Spironolactone | 2MG Estradiol | 0.5MG Dutasteride

I am currently on this trio of medications but I am considering changing it. I will definately continue taking the dutasteride and spironolactone however I am questioning the use of estradiol. I am thinking of switching to estrogel but I am unsure on which one is safer.

Can people recommend me any ideas?

if I may, from this regimen you can expect your estrogen levels to raise dangerously. If money isnt an issue, i would add latanoprost and remove estradiol.

 

[badhabiz]

I want my estrogen levels to raise similar to female ranges, and I want my testosterone levels to be similar to female ranges. Although, what is latanoprost?

(I might end up cutting out the estradiol, if I'm being honest.)

you dont want to raise your estrogen levels like that, believe me. hormones are in a delicate balance, estrogens are useful in male body but not in excess. and the way back from that is long and difficult.
are you sure you dont have any deficiency?
hair loss can be determined by zinc, magnesium or vitamin D def for example. run a blood test for it.
on latanoprost:

1. Roenigk HH Jr. New topical agents for hair growth. Clin Dermatol. (1988)
2. Johnstone MA, Albert DM. Prostaglandin-induced hair growth. Surv Ophthalmol. (2002)
3. Sasaki S, Hozumi Y, Kondo S. Influence of prostaglandin F2alpha and its analogues on hair regrowth and follicular melanogenesis in a murine model. Exp Dermatol. (2005) using examine. com words: Drugs that mimic PGF2α signalling (Latanoprost) can induce hair growth when topically applied via increasing anagen phase. Latanoprost in particular has shown efficacy in primeapes with moderate to advanced levels of androgenic baldness prior to testing, where 500mcg/mL or 0.05% (50mcg/mL barely effective) given at 0.5mL once daily on the frontal scalp (5 days a week) caused 5-10% conversion of vellus hairs to intermediate/terminal hairs, a potency comparable to 5% minoxidil (10% conversion).A subsequent trial in humans using double this dose (0.1% of solution in 50% ethanol; 50µg/L or one drop daily) presenting Hamiltion II-III stages of androgenic hair loss noted that half the group outperformed placebo in hair growth with an average increase (after 22 weeks) of 22% more hair density.

 

[badhabiz]

But I have significantly lower androgen levels due to spironolactone, and my androgen levels will be basically nuked once I start taking cyproterone acetate. Estradiol is what promotes hair growth, even applying it topical in combination with an oral anti-androgen is proven to regrow significant amounts of hair. I'll show the post which inspired me: https://www.hairlosstalk.com/interact/threads/exploring-the-hormonal-route-hair-life.109288/ It definitely is risky when it comes to side effects such as gynecomastia and irreversible sterilisation... I just have to think of a long-term regimen which involves no scalp topicals, and can get me back to an NW0.

I am thinking of this... Continuing with dutasteride, spironolactone at 50MG/day or 100MG/day along with cyproterone acetate at either 25MG/day or 12.5MG/day should be enough to lower my androgen levels significantly. Spironolactone's role is to combat the side effects of oral minoxidil such as water retention and to reduce androgens. Cyproterone acetate's role is to aid in reducing androgens. When it comes to the oral minoxidil I'm not sure about doses... I'm not sure about this particular regimen since estrogen seems to play such a huge role.

I don't have any deficiencies at all. My hair loss was accelerated from orthorexia unfortunately... I was diagnosed with androgenic alopecia officially on the 11th of April although I already suspected it for months.

I understand and I'm sorry to hear that. If i may add something, there's nothing on medical licterature in my very limited knowledge that suggests that you can combat side effects of anti dht/androgens IF you suffer from it (certainly not spironolactone). in that case, you should consider alternative ways because, if you can (and its very likely that you cant) force testo production in order to combat side effects of anti androgens, you will end up raising estrogen to leves that you dont like.