Captain Hook,
can't believe you're only 21! You sound soo intelligent and mature. Since you provided me with that information on latanoprost, bimatoprost, Adenosine, etc, some time ago, I've been doing so much research and trying to decide on a course of treatment. At first I thought I'd start with stemoxydine, Folligen (1-2x/week,) and miconozole nitrate (probably also 1-2x/week.) However, today I found some bimatoprost products online that are much more affordable than I originally thought bimatoprost would be, but still very expensive for frequent and continual use. I want to try Folligen for sure, and the miconozole, and am thinking about also using bimatoprost now. The product I found is .03% bimatoprost; I'm now just trying to figure out how much I would have to use, by that I mean, if I were to use 1 ML, as many people do with minoxidil, would bimatoprost grow/thicken hair where it hasn't been applied directly, the way minoxidil does? I mean, I know it is said that minoxidil is not absorbed systemically, but then how can it grow hair on the scalp where it hasn't been applied, or the face?
1 ML is obviously not going to be enough to cover the whole scalp. If more than 1 ML is needed to produce positive changes with bimatoprost, that makes it economically inaccessible to me. Even with the 1 ML, I'd probably only be using every other night or so.
Do you guys have any thoughts on miconozole? I am really only interested in growth stimulants, as my doctors and I doubt that my hair loss is being caused by DHT, so anti androgens are not the best course of treatment for me right now.
So basically, it's down to stemoxydine, copper peptide products, bimatoprost, and miconozole nitrate. I'd like to just stick with three, but I suppose I could use all of them if I think there may be more benefit than just using three.
Sorry to hijack the thread again, and please forgive me if the products I'm asking about are, in your opinion, just scams/ineffective, and you are put in a position to explain to me (as you may have to many others,) that I would be wasting my time. As I said, I've done a lot of research, mostly on people's personal experiences with these products, and I understand they are all controversial, as most hair loss products seem to be.
Firstly, thank you so much for the kind words, there's a lot of negativity on this forum and you've been nothing but polite to me, I really appreciate it, you're a peach!
To answer your questions, I actually have some first hand experience with latanoprost so I would assume what I say would be applicable to bimatoprost too. I've been prescribed it for ocular hypertension in the left eye, so I have my right eye as a sort of benchmark to compare. That being said, the fact that I only use one drop in the left eye once a day (and have been doing so for 10 years) I've noticed the eyelashes on my left eye are much thicker and longer and keep in mind this is without direct application, this is just local absorption around the ocular orbit, I'm sure you'll see much better results with bimatoprost applied directly. So with that being said I'd say yes, bimatoprost has the propensity to grow/thicken hair where it hasn't been applied directly.
As for miconazole, it's a bit of an enigma. The only study relating it to hair loss is this one
http://www.ncbi.nlm.nih.gov/pubmed/3087363
And as you can see it's not a close relation, it just states that miconazole lowers PGE2, which would make sense since others say it increases PGE1 (they are both beneficial for hair growth but they are antagonistic to each other). There are however no studies proving that miconazole increases PGE1 so all we have are anecdotal reports of some people who have had regrowth from it. I personally do not recommend it simply because of the lack of studies done on it. If you want more options for growth stimulation, topically applied PGE2 is one option, it's very expensive though and I'd say castor oil is surprisingly a cheap alternative option (it contains 90% ricinoleic acid, which is molecularly similar to PGE2 and administration of castor oil is used to induce labour, similar to PGE2, because it activates 2 out of the 4 EP prostanoid receptors, EP3 and EP4, with about one order of magnitude less potency than PGE2 itself)
Study showing the effectiveness of ricinoleic acid:
http://www.pnas.org/content/109/23/9179.full.pdf
That being said, how effective castor oil actually is is anyone's guess. Probably the most noteworthy anecdotal report is the user "swisstemples", he has some photos on his blog (search swisstemples blogspot, I'm sure the moderators don't want me promoting him directly) that shows some very impressive regrowth and 1 mL oral castor oil along with topical castor oil is part of his regimen. He may have been banned here for unwanted behaviour, but we'd be fools to sideline and ignore him. I know I'm certainly going to add it to my regimen perhaps a month after implementing S5 Bedtime Cream, it's 10 AUD for a 473 mL bottle, at 1 mL orally per day, that will last me well over a year, I figure I don't have much to lose.
There is some tentative
in vitro evidence for copper peptides but it's worth mentioning that you should make sure you do your research and ensure that the formula you're using contains a proper concentration that would be effective. (Perhaps someone with more experience on this can chime in?) (Said evidence:
http://www.ncbi.nlm.nih.gov/pubmed/17703734)
Another treatment that's pretty much up in the air and unheard of, something I am going to be personally trialling in the coming months, is selenium disulphide. There are a few studies showing its effect on prostaglandins, specifically its ability to increase PGE2 and inhibit PGD2 synthase (the enzyme that is responsible for the synthesis of harmful PGD2. Androgens like DHT lead to an abnormal amount of PGD2 in the scalp, hence the hype around Kythera's setipiprant, a novel PGD2 receptor antagonist). As to why no one has trialled something like Selsun Blue (1% selenium disulphide shampoo) is anyone's guess, it's cheap and to be honest it at least has some tentative evidence pointing to the fact that it could work, I've seen people on this forum use far less supported compounds and snake oils without any evidence to back them. In fact, go on Wikipedia and search for the Prostaglandin D2 synthase page, go to the reference section on the bottom, click the section that says prostanoid signalling and take a look what is listed under enzyme inhibitors: PGD2 synthase. You'll see the elusive selenium disulphide. Selsun Blue is like, 7 AUD for a 200 mL bottle, using 5 mL twice weekly would last me about 5 months, again, I don't have much to lose by using it.
References:
http://www.ncbi.nlm.nih.gov/pubmed/9344235 http://www.ncbi.nlm.nih.gov/pubmed/10389108
I can't speak much for stemoxydine either, there is some evidence it helps via stimulation of important growth factors for hair (
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500072/) but that's about it.
Hope that helps!