I agree with ix, thats exactly what I did. I believed I was at the full potential of what minoxidil was going to give me after 12-14 months so I switched to once per day applications this summer. No negative effects up to this point. I have always shedded a decent clip but it grew back at the same speed so I don't notice any increase in the thinness. Also, its mucho easier to apply before bedtime along with other topicals rather then applying in the AM and having to wait till it dries out. Also I have to apply over my entire 'horseshoe' area of my scalp resulting in a lot of minoxidil being absorbed into the system. Some of the side effects resulted in what I believed were a bloated face and possible headache.