Microbiome in the hair follicle of androgenetic alopecia patients - Part 2 - A Treatment?

RStGeorge

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This post is Part 2 of the [original post which focused on various studies] that highlighted the contrasting microbiome populations on the scalp of Androgenetic Alopecia sufferers, versus that of healthy scalps.

**But that being the case, so what?**

The following study attempted to evaluate the capacity of Lindera strychnifolia root extract (LsR) to restore a healthy bacterial and fungal scalp microflora, in the belief that the relative micriobiome composition on a scalp can impact hair loss progression. Results below:

**Characteristics of healthy and androgenetic alopecia scalp microbiome: Effect of Lindera strychnifolia roots extract as a natural solution for its modulation**

**Results:** Test analysis of relative abundance comparing healthy and Androgenetic Alopecia subjects showed a significant increase of Cutibacterim acnes (P < 0.05) and Stenotrophomonas geniculata (P < 0.01) in Androgenetic Alopecia subjects. Androgenetic Alopecia scalp condition was also associated with a significant (P < 0.05) decrease of Staphylococcus epidermidis relative abundance.

A lower proportion of Malassezia genus in samples corresponding to Androgenetic Alopecia scalps and an increase of other bacterial genera (Wallemia, Eurotium) were also noted. At the species level, mean relative abundance of Malassezia restricta and Malassezia globosa were significantly lower (P < 0.05) in the Androgenetic Alopecia group.

Eighty-three days of treatment induced a significant decrease in the relative abundance of C. acnes (P < 0.05) and S. geniculata (P < 0.01). S. epidermidis increased significantly (P < 0.05).

At the same time, LsR treatment induced a significant increase in the proportion of M. restricta and M. globosa (P < 0.05).

[Read the Full Study]
 

whatevr

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So, it fixed their microbiome, did that translate to any improvements in hair whatsoever? The study doesn't mention that at all.
 

trialAcc

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So, it fixed their microbiome, did that translate to any improvements in hair whatsoever? The study doesn't mention that at all.
Either way, if this does correct the scalp microbiome, almost everyone with Androgenetic Alopecia should be following this protocol. It's widely observed/reported that most people with Androgenetic Alopecia in their 20s/30s suffer from these poor scalp conditions.
 
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