http://www.ejdv.eg.net/article.asp?...=33;issue=2;spage=63;epage=66;aulast=El-Esawy
Ahouansou
et al. [10] reported an elevated prevalence of hypertension among men with Androgenetic Alopecia, and it has been proposed that both phenomena may be explained by the presence of hyperaldosteronism. Another study
[11] reported that chronic elevation of circulatory levels of aldosterone led to increased anxiety. This explained why some patients with Androgenetic Alopecia may occasionally show heightened anxiety levels.
We observed that aldosterone values were significantly higher (
P < 0.05) among hypertensive cases and that they were lower in hypertensive controls.
Our result was similar to those of Arias-Santiagos
et al. [12],
[13] ; however, they concluded that the increase in aldosterone values in these patients might contribute to other mechanisms in the development of Androgenetic Alopecia.
Serge
et al.
[17] also observed that overexpression of a mineralocorticoid receptor targeting the skin in a double transgenic mouse model induced the development of alopecia
. Similarly, a study published in 2001
[20] unmasked the association between increased aldosterone levels and insulin resistance, which confirmed Matilainen
et al.'s
[21] observation that excess circulating insulin could lead to vasoconstriction and nutritional deficiency in the follicles of the scalp, thus exacerbating the effect of dihydrotestosterone on follicular miniaturization.
