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link: https://www.nature.com/articles/s41467-019-09402-8
Mechanical stretch induces hair regeneration through the alternative activation of macrophages
- Thread starter TurboFixer
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Tight galea btfo
waynakyo
Experienced Member
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About macrophages from a website:
M2 macrophages are alternatively activated by exposure to certain cytokines such as IL-4, IL-10, or IL-13. M2 macrophages will produce either polyamines to induce proliferation or proline to induce collagen production. These macrophages are associated with wound healing and tissue repair.
M2 macrophages are alternatively activated by exposure to certain cytokines such as IL-4, IL-10, or IL-13. M2 macrophages will produce either polyamines to induce proliferation or proline to induce collagen production. These macrophages are associated with wound healing and tissue repair.
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TL;DR microneedling
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Massage the sh*t of our head before and after micro-needling then?
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Interesting paper, I miss Stephen Foote thoughts
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sounds painful to massage a sore head of holes lol
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Not sure if massaging would add any real benefits.
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Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells
Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells
Castellana, Paus, and Perez-Moreno discover that skin resident macrophages signal to skin stem cells via Wnt ligands to activate the hair follicle life cycle.Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their ...
www.ncbi.nlm.nih.gov
M2 macrophages promote wound-induced hair neogenesis
M2 macrophages promote wound-induced hair neogenesis
De novo hair regeneration occurs in scars of normal adult mice. This interesting phenomenon is termed as wound-induced hair neogenesis (WIHN). We hypo…
Suppressed androgen receptor expression promotes M2 macrophage reprogramming through the STAT3/SOCS3 pathway
Suppressed androgen receptor expression promotes M2 macrophage reprogramming through the STAT3/SOCS3 pathway
Macrophages are important mediators of inflammatory cardiovascular diseases, and various macrophage phenotypes exert opposite effects during inflammation. In our previous study, we proved that suppressed androgen receptor (AR) alleviated inflammation ...
www.ncbi.nlm.nih.gov
Macrophage-Derived Extracellular Vesicle Promotes Hair Growth
Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells
Castellana, Paus, and Perez-Moreno discover that skin resident macrophages signal to skin stem cells via Wnt ligands to activate the hair follicle life cycle.Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their ...
www.ncbi.nlm.nih.gov
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α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.
www.nature.com
Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes
Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes
Obesity is a nutritional disorder resulting from a chronic imbalance between energy intake and expenditure. This disease is characterized by inflammation in multiple cell types, including macrophages. M1 macrophage responses are correlated with the progression ...
www.ncbi.nlm.nih.gov
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I don't think heavy massage is really good when someone is already micro-needling. It might put all hair into quick catagen which is a positive in the long run but who wants a massive shed in the short-run. I was also using an AA and the three together essentially caused quick catagen and then quick anagen again but I was completely bald for several months.
I still do micro-needling at least once a week and I am experimenting now with no-pressure microneedling which might provide quicker, less intrusive benefits. Pulling the hairline gently forward, together with the hair in front of the ears might be beneficial. If you look at a partially receded hairline and then push the sides together, it appears that the hairline has actually been stretched backwards, more so in the temples and moved back a few centimeters. This puts stress on the hairline similar to what the chewing muscles might do in terms of stressing the sides and back of existent hair. Microneedling probably helps relieve this stress in my view; I have no comment about the benefits of heavy massage but I think any effects thereof are marginal at best. Micro-needling with both oral and topical minoxidil is probably best in terms of mechanical treatments for those eschewing hormonal approaches like reductase inhibitors.
I still do micro-needling at least once a week and I am experimenting now with no-pressure microneedling which might provide quicker, less intrusive benefits. Pulling the hairline gently forward, together with the hair in front of the ears might be beneficial. If you look at a partially receded hairline and then push the sides together, it appears that the hairline has actually been stretched backwards, more so in the temples and moved back a few centimeters. This puts stress on the hairline similar to what the chewing muscles might do in terms of stressing the sides and back of existent hair. Microneedling probably helps relieve this stress in my view; I have no comment about the benefits of heavy massage but I think any effects thereof are marginal at best. Micro-needling with both oral and topical minoxidil is probably best in terms of mechanical treatments for those eschewing hormonal approaches like reductase inhibitors.
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Interesting, α-ketoglutarate was also identified as a molecule for activating autophagy and hair growth: https://www.cell.com/cell-reports/pdfExtended/S2211-1247(19)30699-0α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.
Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes
Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes
Obesity is a nutritional disorder resulting from a chronic imbalance between energy intake and expenditure. This disease is characterized by inflammation in multiple cell types, including macrophages. M1 macrophage responses are correlated with the progression ...
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- 2,028
Autophagy is clear and apparent with micro-needling. Scar tissue "melts" away each time.