Mdv3100 (enzalutamide) - Superstrong Antiandrogen Topical | HairLossTalk Forums

Mdv3100 (enzalutamide) - Superstrong Antiandrogen Topical

Discussion in 'Antiandrogens - Propecia, Dutasteride, etc.' started by whatevr, Apr 19, 2017.

  1. whatevr

    whatevr Senior Member My Regimen

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    MDV-3100 (Enzalutamide) - triple action AR antagonist

    F_10286.jpg
    (https://en.wikipedia.org/wiki/Enzalutamide)


    MECHANISM OF ACTION

    1) Blocks binding of DHT to the androgen receptor
    2) Impedes movement of the AR into the cell nucleus
    3) Reduces ability of AR to interact with DNA

    See image (click to open):
    MDV-3100-Mechanism-of-Action-fullsize.jpg

    USAGE GUIDELINES

    Frequency of application: 2-3x weekly due to long serum half-life
    Dosage per application: to be determined

    The ideal dose will be determined through user experimentation but will also likely remain somewhat individual.

    A good starting percentage is 2%, which depending on the amount of scalp to be covered, can be between 20 - 60 mg of MDV used per application.

    HOW LONG WILL IT LAST?
    Of course, it depends how much is used. As an example, when used at 2%, with 3 mL to cover the entire scalp, means using about 60 mg, and due to the half-life not recommended to use more than 2-3x weekly, 5 g would last you approx. 250 days (>8 months).

    STORAGE (IMPORTANT!)
    Just like with similar anti-androgens, the raw powder should ideally be kept in a freezer at a temperature of -20°c (-4°F), in which conditions it can last up to 3 years.
    (reference: http://www.selleckchem.com/products/MDV3100.html)

    The finished solution should be kept refrigerated (-4°c / 24.8°F) in batches up to 2 weeks.
    (reference: http://www.eurodiagnostico.com/media/pdf/MDV3100 (Enzalutamide).pdf)

    MAKING A SOLUTION
    KNOWN SOLVENTS: PEG (polyethylene glycol)-400, DMSO
    WILL NOT DISSOLVE IN ETHANOL!

    VEHICLE 1
    30% PEG-400
    40% Ethanol 96%
    30% Distilled water

    VEHICLE 2
    10% DMSO
    70% Ethanol 96%
    20% Distilled water

    VEHICLE 3
    20% PEG-400
    30% Ethanol 96%
    30% Propylene glycol
    20% Distilled water

    ORIGINAL THREAD

     
    #1 whatevr, Apr 19, 2017
    Last edited: Jul 6, 2017
    Quineapig, Maxxorr, rclark and 4 others like this.
  2. buckthorn

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    I've seen this thread of his... don't know why nothing ever came of it. @Swoop and company - what's with this stuff?
     
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  3. whatevr

    whatevr Senior Member My Regimen

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    Putting aside the theory for a minute there.

    It's a shame this guy isn't around. He clearly tried topical application and claims results without side effects. Even though I find it hard to believe, it IS possible. If you look at the second link I posted, the researchers even hint at the possibility of topical application for hair loss in their patent.
    There is often quite a disconnect between the theoretical effects of something and the empirical reality - sometimes even one that can work in our favor. He seems to be the only one that has tried this, perhaps, as unlikely as it sounds on paper, it might be worth trying. There are just so many hoops to jump through as far as actually obtaining and using the stuff. I do agree that the seizure stuff sounds worrying though.
     
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  4. Grasshüpfer

    Grasshüpfer Experienced Member My Regimen

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    Maybe he couldn't post because of the seizure...

    Jokes aside it sounds super interesting. I will keep it in mind as a nuclear option.

    @ForeverLacey you are super helpful. Thank you!


    @antydhtor ?
     
    #4 Grasshüpfer, Apr 19, 2017
    Last edited: Apr 19, 2017
  5. whatevr

    whatevr Senior Member My Regimen

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    :D

    And who says Germans don't have humor?
     
  6. Trichosan

    Trichosan Experienced Member My Regimen

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    So do we ask for a volunteer or randomly selected one of the members here to act as guinea pig? ;)
     
  7. whatevr

    whatevr Senior Member My Regimen

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    I'm a relatively crazy mf so I'd do it, but I just shelled out for 10 g of RU 2 weeks ago and am strapped for cash at the moment.
    Plus, our customs are very trigger happy at seizing weird stuff from China, not sure it would pass.
    I am keeping it in mind if RU fails to maintain, it will probably be my go-to.
     
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  8. Trichosan

    Trichosan Experienced Member My Regimen

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    Laboratory subject list:

    1. Whatevr
     
  9. resu

    resu Senior Member

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    Customs block almost everything I order from outside the EU, I can only imagine what it would be like if they received some mysterious white powder from China.
     
  10. TylerDurdenn

    TylerDurdenn Established Member My Regimen

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    I might have been interested in trying this out, seems alot safer to take some topical than oral, but im no expert at this.. But i would have no idea to get my hands on this stuff. Shame his not around anymore, would be good to know how he is today
     
  11. peewee

    peewee Established Member

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    I'd be interested in this as well but I just bought 20g ru and my dutasteride is at 1.25mg per day and this stuff ain't cheap. Thing is I keep shedding.
    Be great if this guy could come here and give more info on it.
     
  12. kawnshawn

    kawnshawn Established Member

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    I have the funds so I'll make a few grams purchase. The issue is finding a reputable source. There are numerous sellers on Alibaba and after checking they have prices all over the place ranging from 30 to 65 dollars a gram. It doesn't seem expensive as claimed so I'm a bit skeptical.
     
  13. whatevr

    whatevr Senior Member My Regimen

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    MDV-3100-Mechanism-of-Action-fullsize.jpg

    Apparently, MDV3100 doesn't just "block" the androgen receptor.

    It kills it, rapes its corpse then fucks its mother.
     
  14. smyth01

    smyth01 Established Member

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    Unfortunately once a topical is mixed for penetrating the skin, it often goes systematic. Which is why a lot of people wont touch research drugs, topical or oral.
     
  15. TylerDurdenn

    TylerDurdenn Established Member My Regimen

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    But what if u use it in minimal doses? Like with alpicort that whatevr used, lets say you only apply it on a very small area, and then you go to the next area to regrow this aswell and stopped applying where u allready regrowth? If finasteride could hold on to these hair it could be a solutuon? Better than applying these crazy drugs ALL over ur scalp at one i guess
     
  16. whatevr

    whatevr Senior Member My Regimen

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    Due to the molecular weight it's pretty close to approaching the 500 dalton rule for absoprtion, wouldn't be absorbed very easily, one could modify the absorption with vehicle perhaps, which would mean maybe more of it would get absorbed down via the hair shafts(I don't know if this is possible) rather than through the skin.

    If the guy claims no sides who knows maybe it's possible, I doubt he wouldn't notice serious side effects. But going to NW4 to NW2 is surely impressive I don't know many drugs that can do that.

    When I have a bunch of extra cash I will try to obtain some. I'm a NW2 and with this I could get to NW1 for sure.
     
  17. Recon_s

    Recon_s Established Member My Regimen

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    Keep us posted if you go this route, I just started to experiment with RU so if it doesn't go well it would be nice to try another topical
     
  18. Grasshüpfer

    Grasshüpfer Experienced Member My Regimen

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    To go from Ru to Enzalutamide is like going from wine to jet fuel lol.
     
  19. TylerDurdenn

    TylerDurdenn Established Member My Regimen

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    Or going from a life with a full head of hair, to none hair
     
  20. Prada1

    Prada1 Established Member

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    To avoid it from going systemic, couldn't you "cycle" it maybe? Im assuming it goes systemic after a while?
     

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