Mdv3100 (enzalutamide) - Superstrong Antiandrogen Topical

MDV-3100 (Enzalutamide) - triple action AR antagonist


(https://en.wikipedia.org/wiki/Enzalutamide)

MECHANISM OF ACTION
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1) Blocks binding of DHT to the androgen receptor
2) Impedes movement of the AR into the cell nucleus
3) Reduces ability of AR to interact with DNA

See image (click to open):


USAGE GUIDELINES​

Frequency of application: 2-3x weekly due to long serum half-life
Dosage per application: to be determined

The ideal dose will be determined through user experimentation but will also likely remain somewhat individual.

A good starting percentage is 2%, which depending on the amount of scalp to be covered, can be between 20 - 60 mg of MDV used per application.

HOW LONG WILL IT LAST?
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Of course, it depends how much is used. As an example, when used at 2%, with 3 mL to cover the entire scalp, means using about 60 mg, and due to the half-life not recommended to use more than 2-3x weekly, 5 g would last you approx. 250 days (>8 months).

STORAGE (IMPORTANT!)
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Just like with similar anti-androgens, the raw powder should ideally be kept in a freezer at a temperature of -20°c (-4°F), in which conditions it can last up to 3 years.
(reference: http://www.selleckchem.com/products/MDV3100.html)

The finished solution should be kept refrigerated (-4°c / 24.8°F) in batches up to 2 weeks.
(reference: http://www.eurodiagnostico.com/media/pdf/MDV3100 (Enzalutamide).pdf)

MAKING A SOLUTION
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KNOWN SOLVENTS: PEG (polyethylene glycol)-400, DMSO
WILL NOT DISSOLVE IN ETHANOL!

VEHICLE 1
30% PEG-400
40% Ethanol 96%
30% Distilled water

VEHICLE 2
10% DMSO
70% Ethanol 96%
20% Distilled water

VEHICLE 3
20% PEG-400
30% Ethanol 96%
30% Propylene glycol
20% Distilled water

ORIGINAL THREAD​

 

Putting aside the theory for a minute there.

It's a shame this guy isn't around. He clearly tried topical application and claims results without side effects. Even though I find it hard to believe, it IS possible. If you look at the second link I posted, the researchers even hint at the possibility of topical application for hair loss in their patent.
There is often quite a disconnect between the theoretical effects of something and the empirical reality - sometimes even one that can work in our favor. He seems to be the only one that has tried this, perhaps, as unlikely as it sounds on paper, it might be worth trying. There are just so many hoops to jump through as far as actually obtaining and using the stuff. I do agree that the seizure stuff sounds worrying though.

 

And who says Germans don't have humor?

 

I'm a relatively crazy mf so I'd do it, but I just shelled out for 10 g of RU 2 weeks ago and am strapped for cash at the moment.
Plus, our customs are very trigger happy at seizing weird stuff from China, not sure it would pass.
I am keeping it in mind if RU fails to maintain, it will probably be my go-to.

 

Apparently, MDV3100 doesn't just "block" the androgen receptor.

It kills it, rapes its corpse then fucks its mother.

 

Due to the molecular weight it's pretty close to approaching the 500 dalton rule for absoprtion, wouldn't be absorbed very easily, one could modify the absorption with vehicle perhaps, which would mean maybe more of it would get absorbed down via the hair shafts(I don't know if this is possible) rather than through the skin.

If the guy claims no sides who knows maybe it's possible, I doubt he wouldn't notice serious side effects. But going to NW4 to NW2 is surely impressive I don't know many drugs that can do that.

When I have a bunch of extra cash I will try to obtain some. I'm a NW2 and with this I could get to NW1 for sure.