since many have been discussing the mode of action of cetrixine. mast cells are found more in areas of sunlight... and hence on outer skin.. but also more matching male pattern baldness area pattern.
they are pro and anti inflamitory.
lack of uv exposure reduces their antiinflamation effect.
hence long term low uv exposure activates the mast cells.. so only after this then we are sensitised to dht and pg2?
if you google natural mast cell stabilizers... a lot of them have been discused as male pattern baldness curee... curcumin.. quercetin... isoflavsnols etc
so is this the missing link in male pattern baldness mode of action of diff. sensitivety of people
http://onlinelibrary.wiley.com/doi/10.1111/exd.13402/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764846/#!po=11.7886
so over time the skin has lost its mast cells protective effect due to chronic lack of uv long term... i always suspected its an indoor workers disease !
Research tells us that immune cells have vitamin D receptors and that it plays an important role in protecting us from autoimmune disorders. Vitamin D specifically regulates the action of COX, an enzyme that produces prostaglandins, which are one of many inflammatory molecules released (along with histamine) by mast cells when they’re activated. Mast cells can be triggered into releasing these inflammatory elements into the blood stream by stress, high histamine foods, allergies, extremes in temperature and more.
and new male pattern baldness research is on cox inhibitors... so why even bother when low uv exposure is the root cause.
they are pro and anti inflamitory.
lack of uv exposure reduces their antiinflamation effect.
hence long term low uv exposure activates the mast cells.. so only after this then we are sensitised to dht and pg2?
if you google natural mast cell stabilizers... a lot of them have been discused as male pattern baldness curee... curcumin.. quercetin... isoflavsnols etc
so is this the missing link in male pattern baldness mode of action of diff. sensitivety of people
http://onlinelibrary.wiley.com/doi/10.1111/exd.13402/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764846/#!po=11.7886
so over time the skin has lost its mast cells protective effect due to chronic lack of uv long term... i always suspected its an indoor workers disease !
Research tells us that immune cells have vitamin D receptors and that it plays an important role in protecting us from autoimmune disorders. Vitamin D specifically regulates the action of COX, an enzyme that produces prostaglandins, which are one of many inflammatory molecules released (along with histamine) by mast cells when they’re activated. Mast cells can be triggered into releasing these inflammatory elements into the blood stream by stress, high histamine foods, allergies, extremes in temperature and more.
and new male pattern baldness research is on cox inhibitors... so why even bother when low uv exposure is the root cause.
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