Mast Cell Link To male pattern baldness ? Due To Low Uv Exposure

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Jk1

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since many have been discussing the mode of action of cetrixine. mast cells are found more in areas of sunlight... and hence on outer skin.. but also more matching male pattern baldness area pattern.

they are pro and anti inflamitory.

lack of uv exposure reduces their antiinflamation effect.



hence long term low uv exposure activates the mast cells.. so only after this then we are sensitised to dht and pg2?

if you google natural mast cell stabilizers... a lot of them have been discused as male pattern baldness curee... curcumin.. quercetin... isoflavsnols etc

so is this the missing link in male pattern baldness mode of action of diff. sensitivety of people

http://onlinelibrary.wiley.com/doi/10.1111/exd.13402/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764846/#!po=11.7886

so over time the skin has lost its mast cells protective effect due to chronic lack of uv long term... i always suspected its an indoor workers disease !
Research tells us that immune cells have vitamin D receptors and that it plays an important role in protecting us from autoimmune disorders. Vitamin D specifically regulates the action of COX, an enzyme that produces prostaglandins, which are one of many inflammatory molecules released (along with histamine) by mast cells when they’re activated. Mast cells can be triggered into releasing these inflammatory elements into the blood stream by stress, high histamine foods, allergies, extremes in temperature and more.

and new male pattern baldness research is on cox inhibitors... so why even bother when low uv exposure is the root cause.
 
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Vinc2097

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Jk1 said:
since many have been discussing the mode of action of cetrixine. mast cells are found more in areas of sunlight... and hence on outer skin.. but also more matching male pattern baldness area pattern.

they are pro and anti inflamitory.

lack of uv exposure reduces their antiinflamation effect.



hence long term low uv exposure activates the mast cells.. so only after this then we are sensitised to dht and pg2?

if you google natural mast cell stabilizers... a lot of them have been discused as male pattern baldness curee... curcumin.. quercetin... isoflavsnols etc

so is this the missing link in male pattern baldness mode of action of diff. sensitivety of people

http://onlinelibrary.wiley.com/doi/10.1111/exd.13402/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764846/#!po=11.7886

so over time the skin has lost its mast cells protective effect due to chronic lack of uv long term... i always suspected its an indoor workers disease !
Research tells us that immune cells have vitamin D receptors and that it plays an important role in protecting us from autoimmune disorders. Vitamin D specifically regulates the action of COX, an enzyme that produces prostaglandins, which are one of many inflammatory molecules released (along with histamine) by mast cells when they’re activated. Mast cells can be triggered into releasing these inflammatory elements into the blood stream by stress, high histamine foods, allergies, extremes in temperature and more.

and new male pattern baldness research is on cox inhibitors... so why even bother when low uv exposure is the root cause.
Click to expand...

hey ! that looks interesting but i speak french and not really good in english.. so scientific terms are hard for me to understand..

if you could resume this way : in cloclusion of your post, what we actually should do ? (diet, supplements, etc)
 
br1

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Right. but how come a lot of friends of mine, who live in a tropical country are balding? Lots of sun there, close to the equator.
 
whatevr

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Whenever inventing a new theory, always ask yourself 'are there millions of people who disprove it as we speak?'

If yes, then whatever you think is a factor is clearly not anywhere near as much of an important factor in hair loss, or those people would not be balding.

So in other words, even if UV helps turn mast cells into something less bad, it's clearly not enough to overcome all the other factors of male pattern baldness as there are still so many baldheads in sunny countries. Case closed.
 
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for me the interesting link is that their is more mast cells in the male pattern baldness area. and when young and healthy the thickest hair is also on the top of the haid... which makes sense to counteract the uv damage.

so when this mast cell anti inflamatoru effect breaks down as they are lost as the skin changes... then this area thins first !
and only then we are sensitive to dht or anything that increases histamine...i.e alergy reaction.

scalp psoriaris is treated with uv.

its not a matter about geographic locatio. it more how many hours a day you spend in the sun. many office workers are vitamin d defficient. supplementation internaly i have tried has no effect on the scalp skin.

LLT, sulphurorhane and maybe topical vit D is safest way to help without the uv risk ? but this would be early in the process.

how to reverse mast cell loss in skin and advanced male pattern baldness is a diff answer. maybe closer to what folica is doing is needed i e dermabrasion dermarolling to remodel skin back to how it was before ? whilst doing the vit d . LLT . sulphorophane and cetrizine for pgd2 ?

mast cell and wounding are related
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985512/
 
whatevr

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Jk1 said:
for me the interesting link is that their is more mast cells in the male pattern baldness area. and when young and healthy the thickest hair is also on the top of the haid... which makes sense to counteract the uv damage.

so when this mast cell anti inflamatoru effect breaks down as they are lost as the skin changes... then this area thins first !
and only then we are sensitive to dht or anything that increases histamine...i.e alergy reaction.

scalp psoriaris is treated with uv.

its not a matter about geographic locatio. it more how many hours a day you spend in the sun. many office workers are vitamin d defficient. supplementation internaly i have tried has no effect on the scalp skin.

LLT, sulphurorhane and maybe topical vit D is safest way to help without the uv risk ? but this would be early in the process.

how to reverse mast cell loss in skin and advanced male pattern baldness is a diff answer. maybe closer to what folica is doing is needed i e dermabrasion dermarolling to remodel skin back to how it was before ? whilst doing the vit d . LLT . sulphorophane and cetrizine for pgd2 ?

mast cell and wounding are related
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985512/
Click to expand...

I've had success with 660 nm and 830 nm lights. Not sure about UV. They increase growth factors.
 
whatevr

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Vinc2097 said:
how much does it cost ? what are you using
Click to expand...

https://lifegivingstore.com/orange_and_red_light_therapy_lgs1.html

and

https://redlightman.com/product/infrared-light-device-mini/
(which is identical to https://lifegivingstore.com/infrared_light_therapy_lgs8.html just cheaper if you're in the US)

If I was buying now I would get lights with isolated wavelengths, because multiple wavelengths simulatenously can interfere with one another. The studies support 830 and 660 nm at separate times, there is not much guarantee if you use a light source with multiple wavelengths (it still works but it may work better if it was a single one, if you get my meaning).

I would get:
https://redlightman.com/product/infrared-mini-830/
and
https://www.amazon.com/ABI-Booster-Flowering-Spectrum-Enhancement/dp/B01H2Y5U4M
or
https://www.amazon.com/dp/B0744GY7TP/ref=psdc_14252951_t1_B01H2Y5U4M
 
A

abcdefg

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Too much UV exposure and then your at increased risk of skin cancer. Pick your poison I guess male pattern baldness or cancer. Any more then 20 minutes or so of sun is bad for you. Nothing about the sun is good for you minus a little to convert vitamin D.
 
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another new study linking vit d and mast cell activation !
hi
so i think any treatment is damned to fail due to activated mast cells unless vit d / uv treatment/ llt is used as the starting point.

https://www.ncbi.nlm.nih.gov/m/pubmed/27998003/

how many people on here mainly work indoors or office jobs ? it would be interesting to do a survey and the correlation around times of male pattern baldness rapid progression as i bet they correlate well. as well homeless people often have thick hair with bad diets and stress as they are always outdoors.

geographically if you see people with the thickest and darkest hair come from highest sun exposure places... eg Rhodes locals hair is thick like straw ! vs some northern europeans thin and blond.

so it seems these mast cells are the main controllers of hair growth and hair regression due to lack of sun on scalp and male pattern baldness.

sun and uv exposure is like exercise on the body... in moderation and often this inflamattion is good as its anti inflammatory on the mast cells. too much and too random is not the same as it will just be pro inflamattory.i.e burning and when ur skin is lacking mast cells and local vitd.
 
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TK421

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Interesting theory, but how do you explain how Kelly Slater went bald?
 
itsAlright

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Jk1 said:
another new study linking vit d and mast cell activation !
hi
so i think any treatment is damned to fail due to activated mast cells unless vit d / uv treatment/ llt is used as the starting point.

https://www.ncbi.nlm.nih.gov/m/pubmed/27998003/

how many people on here mainly work indoors or office jobs ? it would be interesting to do a survey and the correlation around times of male pattern baldness rapid progression as i bet they correlate well. as well homeless people often have thick hair with bad diets and stress as they are always outdoors.

geographically if you see people with the thickest and darkest hair come from highest sun exposure places... eg Rhodes locals hair is thick like straw ! vs some northern europeans thin and blond.

so it seems these mast cells are the main controllers of hair growth and hair regression due to lack of sun on scalp and male pattern baldness.

sun and uv exposure is like exercise on the body... in moderation and often this inflamattion is good as its anti inflammatory on the mast cells. too much and too random is not the same as it will just be pro inflamattory.i.e burning and when ur skin is lacking mast cells and local vitd.
Click to expand...

If this is true why would India have such high occurrence of Androgenetic Alopecia? You see men who start with incredibly thick hair (diameter and density wise) in India, some lose their hair very rapidly and some retain it for years. Everyone in India is getting a strong dose of sun, so clearly there is something else at play.
 
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itsAlright said:
If this is true why would India have such high occurrence of Androgenetic Alopecia? You see men who start with incredibly thick hair (diameter and density wise) in India, some lose their hair very rapidly and some retain it for years. Everyone in India is getting a strong dose of sun, so clearly there is something else at play.
Click to expand...
geography is one thing but its also how many hours a day u spend in the sun.

its more about indoor vs outdoor worker's you should compare than geography as most people stay out of the sun due to work hours. and extended periods of time due to lack of sun. so even if u did work outdoors ur whole life and then indoors for a few years the theory would be that male pattern baldness progresses those years working indoors more rapidly.

hence why anyone is susceptible even in high sun locations who has the malfunctioning vit d receptor gene variation

https://www.hairlosstalk.com/intera...licated-in-hair-loss-and-calcipotriol.105281/

https://www.vitamindcouncil.org/vit...portant-role-in-the-pathogenesis-of-alopecia/
 
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whatevr

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Aliens said:
Did you get regrows with it?
Click to expand...

A bit of thickening and just a bit of regrowth of the hairs that died most recently, yes. That also means maintenance, on nothing but these lights.

However for someone with really aggressive Androgenetic Alopecia it won't do it - you're gonna need more. But I would include it in every regimen, it has potential and probably works even better in combination with other things.

The bad thing about LLLT is that it reduces PGE2, so if you add that topically you can probably get all the benefits without any of the negatives.
 
inmyhead

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Jk1 said:
for me the interesting link is that their is more mast cells in the male pattern baldness area. and when young and healthy the thickest hair is also on the top of the haid... which makes sense to counteract the uv damage.

so when this mast cell anti inflamatoru effect breaks down as they are lost as the skin changes... then this area thins first !
and only then we are sensitive to dht or anything that increases histamine...i.e alergy reaction.

scalp psoriaris is treated with uv.

its not a matter about geographic locatio. it more how many hours a day you spend in the sun. many office workers are vitamin d defficient. supplementation internaly i have tried has no effect on the scalp skin.

LLT, sulphurorhane and maybe topical vit D is safest way to help without the uv risk ? but this would be early in the process.

how to reverse mast cell loss in skin and advanced male pattern baldness is a diff answer. maybe closer to what folica is doing is needed i e dermabrasion dermarolling to remodel skin back to how it was before ? whilst doing the vit d . LLT . sulphorophane and cetrizine for pgd2 ?

mast cell and wounding are related
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985512/
Click to expand...

Can you guys stop with this stupid theory? My brother spends like 4-8 hours in the sun daily and he is Norwood 5 at 25

whatevr said:
A bit of thickening and just a bit of regrowth of the hairs that died most recently, yes. That also means maintenance, on nothing but these lights.

However for someone with really aggressive Androgenetic Alopecia it won't do it - you're gonna need more. But I would include it in every regimen, it has potential and probably works even better in combination with other things.

The bad thing about LLLT is that it reduces PGE2, so if you add that topically you can probably get all the benefits without any of the negatives.
Click to expand...

Do you have any pictures? I've seen hundred of people claiming results from something without any proof. Just look at daro thread. Guy claimed success with that stuff ( no stuff ), people spent their money on it - not a single guy with positive results.
 
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