Male Pattern Alopecia Regrowth Following Topical Fluorouracil Therap

[Otis Mack]

https://sci-hub.se/10.1001/jama.1977.03280120041009


When seen on Oct18,1976,after 21days of treatment,a confluent,brisk erythema and edema engulfed the scalp,nose,and temples.The fluorouracil therapy was discontinued,and the reaction subsided after three weeks of 0.5% triamcinolone therapy.The patient was not seen again until March10,1977,when he returned specifically to say thanks for the regrowth of hair he was experiencing




I have seen pictures of treatment with topical fluorouracil and it looks like skin of a patient who fell out of a moving car.

The skin gets completely "tore up" and triggers a massive repair phase.

Fluorouracil treatment:
https://www.self.com/story/photos-skin-precancer-treatment

 

[EndlessPossibilities]

So I would imagine this would case hair fall first then maybe possibly activate new stem cells and regrow hair to some degree. Probably not enough to be cosmetically significant.

 

[zaman]

Fluorouracil has some relation to TWIST1 in its mechanism of tumour suppression.

"TWIST1 suppression in CRC cells sensitizes them to 5-FU-induced apoptosis."