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I'm going to make a topical for myself. Going off my regimen soon (using completely nothing) and just going to do a little experiment. I have quite aggressive Androgenetic Alopecia.
I'm not going to be making any guarantees about this topical. I'm not touting it as being a "cure" (we've heard that one to many times). Neither do I give a guarantee that it will even maintain your hair. However it should slow down the progression of Androgenetic Alopecia. To make a random example it might work like this across individuals;
Perhaps in some it will have a cosmetic effect. However it will be primarily a topical based on "damage control" in Androgenetic Alopecia. People who can't use treatments like finasteride/dutasteride or experimental treatments like RU58841 are quickly doomed as they have no options to slow down the progression of Androgenetic Alopecia.
So why not combine a few treatments that work through damage control? It would be nice if some people can replicate me in their own research so we'll have more feedback. I'm thinking of the following ingredients
- S-equol
S-equol is a non-steroidal selective agonist of the estrogen receptor beta (ER-β). When taken systemically it able to reduce DHT levels by ~20% and it is hypothesized s-equol is able to bind to DHT directly (1).
The benefits in relation to Androgenetic Alopecia would be primarily through s-equol being a selective agonist of the estrogen receptor beta. Observations tell us that estrogen seems to be protective of hair follicles. The anti-androgen activity that might occur through topical application is a plus.
- Alfatradiol (optional)
Is a (weak) 5a-reductase inhibitor. Has some weak biological activity towards estrogen receptor alpha (ER-α). There are several studies about this being beneficial for men & women albeit with weak evidence and it is actually sold as a treatment for Androgenetic Alopecia in germany.
- Anti-oxidant, tempol or orgotein
Oxidative stress seems to be a critical component of Androgenetic Alopecia progression. Multiple studies are indicating this. Therefore it might be handy to have a pure anti-oxidant. Tempol is a SOD mimetic and can be beneficial in controlling the oxidative stress. You can see for instance in this study that SOD2 (major intracellular anti-oxidant enzyme) is being downregulated progressively in prostate cancer and this contribute to AR overexpression. Tempol was able to lower cellular superoxide levels and inhibit AR in that study.
@InBeforeTheCure has shown us recently the following;
Now that prostate cancer study doesn't necessarily mean anything at all regarding AR, I just used it as an example. However controlling the oxidative stress would probably be a good move in which Tempol can help. There was a clinical trial that used a 7% tempol gel to prevent hair loss from radiotherapy (2).
- DGLA (Dihomo-γ-linolenic acid)
See Brotzu. Effect would be hair follicle cycle modulation.
- Carnitine
See Brotzu. He says it would facilitate metabolism of lipid chains through beta-oxidation. Why not dump it in there also. So it would act through damage control. It exhibits overall also anti-oxidant properties, but probably nowhere as potent as tempol.
So all in all a topical might consist of the following components
- S-equol
- Alfatradiol
- Tempol
- DGLA
- Carnitine
Basically it's like Brotzu his lotion but with spironolactone added and a potent SOD mimetic (tempol). Should be even better. This won't be incorporated into liposomes, but liposomes are doubtful too if you look at some studies that mention that they break down in contact with the skin; http://sciencenordic.com/liposomes-skin-creams-don’t-work.
The power of these ingredients would be primarily through a multi-angle approach to work through damage control.
Problems with this topical would be sourcing as you would have to source multiple ingredients. We could work that out though.
However a bigger problem would be the stability and the solubility of all these ingredients in one topical. But it's workable. In worst case it would have to be spread across two topicals and maybe mixed freshly. Stability would need to be tested for several months. Mixing freshly would be probably the best thing initially.
It would be nice to get feedback. It might become a total failure, well that's fine, but perhaps it will make some people happy. I'll source the ingredients and we'll follow out a way to get this stuff suspended. Do some people want to get on this? You would get the raw ingredients supplied. And you could mix it yourself. Safety, side-effects is completely up to you, your risk.
Does anyone else feel something for this?
I'm not going to be making any guarantees about this topical. I'm not touting it as being a "cure" (we've heard that one to many times). Neither do I give a guarantee that it will even maintain your hair. However it should slow down the progression of Androgenetic Alopecia. To make a random example it might work like this across individuals;
Perhaps in some it will have a cosmetic effect. However it will be primarily a topical based on "damage control" in Androgenetic Alopecia. People who can't use treatments like finasteride/dutasteride or experimental treatments like RU58841 are quickly doomed as they have no options to slow down the progression of Androgenetic Alopecia.
So why not combine a few treatments that work through damage control? It would be nice if some people can replicate me in their own research so we'll have more feedback. I'm thinking of the following ingredients
- S-equol
S-equol is a non-steroidal selective agonist of the estrogen receptor beta (ER-β). When taken systemically it able to reduce DHT levels by ~20% and it is hypothesized s-equol is able to bind to DHT directly (1).
The benefits in relation to Androgenetic Alopecia would be primarily through s-equol being a selective agonist of the estrogen receptor beta. Observations tell us that estrogen seems to be protective of hair follicles. The anti-androgen activity that might occur through topical application is a plus.
- Alfatradiol (optional)
Is a (weak) 5a-reductase inhibitor. Has some weak biological activity towards estrogen receptor alpha (ER-α). There are several studies about this being beneficial for men & women albeit with weak evidence and it is actually sold as a treatment for Androgenetic Alopecia in germany.
- Anti-oxidant, tempol or orgotein
Oxidative stress seems to be a critical component of Androgenetic Alopecia progression. Multiple studies are indicating this. Therefore it might be handy to have a pure anti-oxidant. Tempol is a SOD mimetic and can be beneficial in controlling the oxidative stress. You can see for instance in this study that SOD2 (major intracellular anti-oxidant enzyme) is being downregulated progressively in prostate cancer and this contribute to AR overexpression. Tempol was able to lower cellular superoxide levels and inhibit AR in that study.
@InBeforeTheCure has shown us recently the following;
Now that prostate cancer study doesn't necessarily mean anything at all regarding AR, I just used it as an example. However controlling the oxidative stress would probably be a good move in which Tempol can help. There was a clinical trial that used a 7% tempol gel to prevent hair loss from radiotherapy (2).
- DGLA (Dihomo-γ-linolenic acid)
See Brotzu. Effect would be hair follicle cycle modulation.
- Carnitine
See Brotzu. He says it would facilitate metabolism of lipid chains through beta-oxidation. Why not dump it in there also. So it would act through damage control. It exhibits overall also anti-oxidant properties, but probably nowhere as potent as tempol.
So all in all a topical might consist of the following components
- S-equol
- Alfatradiol
- Tempol
- DGLA
- Carnitine
Basically it's like Brotzu his lotion but with spironolactone added and a potent SOD mimetic (tempol). Should be even better. This won't be incorporated into liposomes, but liposomes are doubtful too if you look at some studies that mention that they break down in contact with the skin; http://sciencenordic.com/liposomes-skin-creams-don’t-work.
The power of these ingredients would be primarily through a multi-angle approach to work through damage control.
Problems with this topical would be sourcing as you would have to source multiple ingredients. We could work that out though.
However a bigger problem would be the stability and the solubility of all these ingredients in one topical. But it's workable. In worst case it would have to be spread across two topicals and maybe mixed freshly. Stability would need to be tested for several months. Mixing freshly would be probably the best thing initially.
It would be nice to get feedback. It might become a total failure, well that's fine, but perhaps it will make some people happy. I'll source the ingredients and we'll follow out a way to get this stuff suspended. Do some people want to get on this? You would get the raw ingredients supplied. And you could mix it yourself. Safety, side-effects is completely up to you, your risk.
Does anyone else feel something for this?
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