Well, study linked above was conducted on mice, it is yet to determine whether it would be effective in Androgenetic Alopecia but as I have read, chinese researcher on the other forum(Chlorine dioxide topic) gives credit to that finding. He is convinced that his method (CD) while injuring the skin, creats massive activation of stem cells - which as we know by now are activated by some kind of macrophages.
Why these process isn't working on our scalps then? I have read a study that high dose of androgens impair macrophages fCyr receptors. Our androgen receptors are broken, and DHT alternates the cell enviroment so that macrophages cant do what they have to do. It is not their fault - We are still able to regenerate cells after injury in other parts of body even at back of our head where DP cells have the same androgen receptors BUT smaller amount of them.
We ve got 2 options:
1) Improve regenerative mechanism by wounding and also increase IGF-1 -> B-cat (wnt pathaway), improving immune system may also help, even improving circulation can - more macrophages can get to the DP
2) Inhibit DHT nearby follicles, our receptors ve got problem with it, we need good inhibitor with no side effects
And speaking of new treatments:
- Replicel - alternates DSC cells which should became just like on the back - as their's CEO said there are receptors there - havent seen proof yet - but hey I am bro scientist, he is normal one
- Histogen - serum which contains growth factors and activators - they ve got some kind of igf-1 exhibitor
- sm04554- wnt proteins - 300 participants in phase 2 trial
- bimatoprost - phase 2b also
- follica- still in game
- CD from China
- pilofocus and PRP - next gen hair transplant
- 3d culturing of dp and ephiletial cell for hair multiplication
- dutasteride for everyone
- cb-03
There is sonething going on
