It seems like there's people everywhere doing hair cloning now.

[Raccooner]

any so-called 'scientists' performing initial trials on mice, and then PUBLISHING their success, should have their scalps ripped off. testing on mice doesn't mean sh*t. you can take a literal sh*t on mice and they will regrow their f*****g hair.

I have to disagree in one sense of what you said. Too many people are not seeing the obvious in why this matters. If these mice can grow a person's human hair and well for that matter, those hair and skin strips can be harvested from the mouse and used in hair transplantation to the same individual. In other words, we likely have an option at this point. It may not be ideal, but at least it is a start. dNovo demonstrated exceptional hair growth in their mice models. I am hoping they consider my human hair grown on a mouse to transplant to human scalp idea. I wish we could get these procedures done on demand. After me explaining this, do you see the situation differently in that this is not a failure or meaningless but that we may have something that could be put to use in hair transplantation? Also, from the ethical standpoint, if one is worried about harming the mouse, they don't live too long. The hair could be harvested once the mouse has passed on. The big thing getting in the way is convincing the scientists to do this experiment I propose. Sadly, they are afraid of what could potentially go wrong and have their careers and lives upended. On the other hand, if the experiment is a success, they stand a lot to gain in reputation. Do you think my idea is one worth a try? If we could gather enough support, perhaps we could give the scientists enough encouragement and support to give it a go?

 

[Alexander Demidovich]

I see the topic on this forum is still interesting to people! My things are moving forward.I think everything will work out.

 

[Alexander Demidovich]

This video ia from 2019?

Yes.

 

[Raccooner]

I see the topic on this forum is still interesting to people! My things are moving forward.I think everything will work out.

Hi Alexander,

Tell me what's moving forward on your end? Any new developments?

This post, which was made specifically for you, seems to have morphed into covering other groups of scientists working on hair loss too. Ernesto Lujan of dNovo, explained more of the process by which he generated human hair in mice, so that has been covered here. Here is the recent article covering him: Interview With Ernesto Lujan PhD Of dNovo: Reprogramming Hair Stem Cells – Follicle Thought.

Greetings,
Jeffrey

 

[Alexander Demidovich]

Hi Jeffrey, you know my method is completely different. He is more natural. I get advice from specialists, and I think that a team can come together.
Also, these people had similar reasoning before.

Look at the link to the article.

Fig. 2. Localization of putative stem cells of the bulge region (blue)...

Download scientific diagram | Localization of putative stem cells of the bulge region (blue) and hair germ cells (red) in the mouse telogen hair follicle. from publication: Hair follicle predetermination | Recent genetic and molecular studies of hair follicle (HF) biology have provided...

www.researchgate.net

 

[H]

skin strips can be harvested from the mouse and used in hair transplantation

So they have to implant the hairs off the mice like a regular transplant or they have to implant the skin strip?

 

[Raccooner]

So they have to implant the hairs off the mice like a regular transplant or they have to implant the skin strip?

They first implant the human skin graft with induced human hair stem cells on the mice (to grow the hair), then remove the skin graft with hair once it's grown to transplant to the human. I think this is best done right after the mouse dies naturally in order for the process to be humane.

 

[H]

They first implant the human skin graft with induced human hair stem cells on the mice (to grow the hair), then remove the skin graft with hair once it's grown to transplant to the human. I think this is best done right after the mouse dies naturally in order for the process to be humane.

I guess so that seems like alot of mice depending on how advanced you are and itll be the same scarring youd get with multiple fut's which is unfortunate maybe you wont be able to see though.

 

[Raccooner]

I guess so that seems like alot of mice depending on how advanced you are and itll be the same scarring youd get with multiple fut's which is unfortunate maybe you wont be able to see though..

It depends where the skin provided is coming from and how much.

 

[H]

It depends where the skin provided is coming from and how much.

Wouldnt they take it from the scalp?

 

[Raccooner]

Wouldnt they take it from the scalp?

That seems to be most likely.

 

[JohnDoe5]

The two that come to mind are Replicel/Shiseido and Histogen. I'm pretty sure Histogen would be considered hair cloning and I know that Replicel/Shiseido would be.

Histogen is not hair cloning. Replicel/Shiseido are hair cloning. Intercytex was hair cloning. Bosley had a hair-cloning research group but they failed too. They all failed because of the inductivity problem.

 

[Joxy]

Histogen is not hair cloning. Replicel/Shiseido are hair cloning. Intercytex was hair cloning. Bosley had a hair-cloning research group but they failed too. They all failed because of the inductivity problem.

It is not only inductivity problem, but also you must control stem cells how they behave inside the body. That is also very big problem.

 

[pegasus2]

Can you summarize the inductivity problem?

There is no inductivity problem anymore(ability of cultured cells to maintain inductivity). This hurdle was solved years ago by Tsuji. I don't know what issues they are running into now

 

[JohnDoe5]

There is no inductivity problem anymore(ability of cultured cells to maintain inductivity). This hurdle was solved years ago by Tsuji. I don't know what issues they are running into now

Even if Tsuji has solved the inductivity problem any technique he uses to solve the inductivity problem would belong to him and no other companyt or research group can use it without his permission. And we can't even be sure that Tsuji has solved the inductivity problem for his own technology yet.

 

[pegasus2]

Even if Tsuji has solved the inductivity problem any technique he uses to solve the inductivity problem would belong to him and no other companyt or research group can use it without his permission. And we can't even be sure that Tsuji has solved the inductivity problem for his own technology yet.

They can, and they do. It's literally not a problem anymore for anyone

 

[JohnDoe5]

Can you summarize the inductivity problem?

In order for hair cells to grow hair all over the scalp patients would need a lot of those hair cells. Hence, hair cells have to be multiplied A LOT by way of culture. The problem is that hair cells lose their ability to grow hair in culture. This is the hair inductivity problem. They have been able to produce large amounts of cells in culture for some time but when they culture hair cells they turn into skin cells. Scientists have to figure out how to make hair cells retain their ability to INDUCE hair growth (during culture) instead of turning into skin cells.

 

[JohnDoe5]

It is not only inductivity problem, but also you must control stem cells how they behave inside the body. That is also very big problem.

I have not read where scientists are claiming that control over stem cells is a big problem. I have read that scientists are saying the hair inductivity problem is the ONLY big problem. Can you please explain your theory that control of stem cells is also a big problem because I really think you're making that up?

 

[Joxy]

They can, and they do. It's literally not a problem anymore for anyone

Any source about your claiming?

 

[JohnDoe5]

Any source about your claiming?

And really, he shouldn't just show that a single hair researcher can preserve hair INDUCTIVITY during culture, he should ALSO show that the researchers/companies that have hair growth treatments in the pipeline have that technology as well. For example, if Jahoda or one other scientist can preserve inductivity during mass-pass culture that will not help d'Novo unless d'Novo works out an agreement with Jahoda to use Jahoda's inductivity technology. All of the cell-based treatments need a solution to this problem or when they culture hair cells to make enough hair cells to grow lots of hair those cells will turn into skin cells.

Pegasus claims that Tsuji has developed technology to preserve inductivity during mass-pass culture, and he might be right, but it does seem like if Tsuji has truly succeeded at that, and if Tsuji has proven to the world that he can do that, then Tsuji wouldn't be having trouble getting funding for his technology. Last I heard he was trying to crowdsource funding to pay for clinical trials BUT IMO if he really had the solution to the inductivity problem then he would have companies throwing investment dollars at him.