IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation
Wound-induced hair follicle neogenesis (WIHN) is a phenomenon of hair neogenesis that occurs at the center of a scar when the wound area is sufficiently large. Neogenic hair follicles are separated from the pre-existing follicles at the wound edge by ...
www.ncbi.nlm.nih.gov
IL-36α is upregulated in de novo hair follicle growth areas and can promote wound epithelialization and WIHN.
Proteomic analysis showing 28 upregulated proteins in the inner area (de novo hair follicle growth area) that are involved in biological regulation.
Genes Fold change (inner vs. outer) P-value Biological process
Signaling Developmental process Inflammatory response Tnn 2.262 0.000 ✓ Grb10 2.147 0.004 ✓ Krt19 2.035 0.007 ✓ ✓ Pawr 1.880 0.028 ✓ ✓ Txndc9 1.821 0.026 IL-36α 1.800 0.009 ✓ Gsto1 1.795 0.001 Krt6a 1.789 0.000 ✓ ✓ Yod1 1.783 0.003 ✓ Rhoc 1.740 0.043 ✓ ✓ Sptlc1 1.708 0.037 Prkd3 1.675 0.015 ✓ Eps8l2 1.669 0.033 Klk7 1.648 0.004 Tab1 1.642 0.028 ✓ ✓ Hist1h3b 1.633 0.007 Aif1 1.624 0.012 ✓ ✓ Dek 1.599 0.001 Hnrnpa0 1.598 0.002 ✓ Stfa1 1.596 0.001 Arg1 1.589 0.006 ✓ Edf1 1.589 0.008 ✓ Crabp1 1.578 0.003 Taf5l 1.571 0.001 Glrx 1.571 0.025 Igf2bp2 1.530 0.018 Ferritin 1.513 0.038 Eif1 1.502 0.012