IL-36α Promoted WIHN via Hair Follicle Stem/Progenitor Cell Proliferation

[pegasus2]

Checking your browser - reCAPTCHA

IL-36α is upregulated in de novo hair follicle growth areas and can promote wound epithelialization and WIHN.

Proteomic analysis showing 28 upregulated proteins in the inner area (de novo hair follicle growth area) that are involved in biological regulation.

Genes​	Fold change (inner vs. outer)​	P-value​	Biological process ​
			Signaling​	Developmental process​	Inflammatory response​
Tnn​	2.262​	0.000​		✓​
Grb10​	2.147​	0.004​	✓​
Krt19​	2.035​	0.007​	✓​	✓​
Pawr​	1.880​	0.028​	✓​	✓​
Txndc9​	1.821​	0.026​
IL-36α​	1.800​	0.009​			✓​
Gsto1​	1.795​	0.001​
Krt6a​	1.789​	0.000​	✓​	✓​
Yod1​	1.783​	0.003​	✓​
Rhoc​	1.740​	0.043​	✓​	✓​
Sptlc1​	1.708​	0.037​
Prkd3​	1.675​	0.015​	✓​
Eps8l2​	1.669​	0.033​
Klk7​	1.648​	0.004​
Tab1​	1.642​	0.028​	✓​	✓​
Hist1h3b​	1.633​	0.007​
Aif1​	1.624​	0.012​	✓​		✓​
Dek​	1.599​	0.001​
Hnrnpa0​	1.598​	0.002​			✓​
Stfa1​	1.596​	0.001​
Arg1​	1.589​	0.006​		✓​
Edf1​	1.589​	0.008​		✓​
Crabp1​	1.578​	0.003​
Taf5l​	1.571​	0.001​
Glrx​	1.571​	0.025​
Igf2bp2​	1.530​	0.018​
Ferritin​	1.513​	0.038​
Eif1​	1.502​	0.012​

 

[kiwi666]

Checking your browser - reCAPTCHA

Group buy ‍

 

[FollicleGuardian]

Whenever @pegasus2 post a thread, my dopamine goes through the roof lmao

 

[Selb]

Whenever @pegasus2 post a thread, my dopamine goes through the roof lmao

He’s the only one with the confidence and know how to actually do experimental crap. I’m betting he finds the cure before any company.

Speaking of experimental stuff, @pegasus2, in cases of scarring alopecia, is there any reason why microneedling wouldn’t regenerate the follicles by clearing the scar tissue and initiating growth? I always get the same answer when asking about scarring alopecia, and that hair is permanent lost.

 

[FollicleGuardian]

He’s the only one with the confidence and know how to actually do experimental crap. I’m betting he finds the cure before any company

Spot on! Hahah I actually agree, he’s going to find the cure before these shitty companies..

 

[FollicleGuardian]

Group buy ‍

Would be nice. But human recombinant proteins are hard to synthezise, and the price is just skyhigh. Probably need an analogue such as KY was developed to improve PTD-DBM injections.