I Am Thinking Seriously. Please Tell Me.

[Daiki]

I am 23 years old Japanese. And it is in Norwood 2. I started alopecia from the age of 17, I decided to take medicine a week ago, I studied variously and found out that I needed ru 58841, minoxdil, finasteride, nezoral. And I got everything ready. However, there is one thing I do not understand. It's about scalp dht and follicular dht. I studied variously and I learned that finasteride is dose - independent. So, I plan to start with a minimum of 0.05 mg and purchase 0.2 mg Propecia. However, there is also information that scalp dht has nothing to do with the amount of hair, so I will not study it from now




https://translate.googleusercontent...68440/&usg=ALkJrhgQfiLjWDU_hCMAAg-HbP_kUsY2mA


頭皮と血清

https://

translate.googleusercontent.com/translate_c?depth=1&nv=1&rurl=translate.google.co.jp&sp=nmt4&tl=ja&u=http://hairlosshelp.com/forums/mess...=37069&usg=ALkJrhi7zfmEzkCPsJ2gToMAcbbyPgA2Mg



局所と頭皮

https://translate.googleusercontent...98373/&usg=ALkJrhiCzL-cu1TD2JxlyvI8EXauA5tH8w


頭皮

https://

translate.googleusercontent.com/translate_c?depth=1&nv=1&rurl=translate.google.co.jp&sp=nmt4&tl=ja&u=https://www.hairlosstalk.com/intera...19470/&usg=ALkJrhiGyKXaPagwOY08pDPkuEmIiXgyWg



容量と副作用

https://

translate.googleusercontent.com/translate_c?depth=1&nv=1&rurl=translate.google.co.jp&sp=nmt4&tl=ja&u=https://tophairlosstreatments.com/b...-loss/&usg=ALkJrhguw9JrPuB3Vn-PTvpu3a4q06II4w


容量と副作用

https://translate.googleusercontent...5.html&usg=ALkJrhg0eebtSHqsTSaSqq68GRba9S-82A


容量と頭皮

https://translate.googleusercontent...page-2&usg=ALkJrhialh7jhcXRvV4E7lRIOB1BBi_YLg


https://translate.googleusercontent...page-5&usg=ALkJrhiN26EjJlCB8IgpIklw6wZfpeNQsQ


https://translate.googleusercontent...1d1513&usg=ALkJrhjIkdAWAndD1HYENfw5Svg5O-5-Ig


https://translate.googleusercontent...-loss/&usg=ALkJrhhyQ9-4JOTct5oeTOhQ8C_DSqpUNA


https://translate.googleusercontent...page-2&usg=ALkJrhg1qI9SnZvX0_-JW8QtNcHQEsFTkQ


https://translate.googleusercontent...98373/&usg=ALkJrhii5jFLDfVtinwpp0JAjUngKiup1A


https://translate.googleusercontent...kJrhgo4iRKyIk-X3z83lPOWCQTNzIZcg#post-1091402


https://translate.googleusercontent...2.html&usg=ALkJrhgFU6Hq8NLEKyI1oNDy6_LOITIR1A


https://translate.googleusercontent...77349/&usg=ALkJrhilggr5V8ySPvzj_qaMdCBdziHdXA


https://translate.googleusercontent...51576/&usg=ALkJrhixhidisS3vjJWiAL0fc4yGrkbu7g


https://translate.googleusercontent...-work/&usg=ALkJrhidhopcfI5Hy5zhHXacSPDTliHm0A

 

[Athlete1987]

Welcome to hairlosstalk.

I’m not sure on the significance of scalp DHT vs follicular DHT but hopefully someone can answer your question.

 

[Daiki]

Thank you, I appreciate your concern.

 

[UberBaldaten]

You should not be afraid of DHT inhibition at age of 23. I have started finasteride since 19 and am doing fine.
It is true that inhibition of serum DHT is not same as follicular one.

I assume that there is a certain threshold where after dropping certain % of DHT in follicules, the other hormones such as estrogen can combat the damage, or keep it at bay.

 

[Daiki]

Thank you Indeed it is interesting. So, do you think that side effects occur due to disorder of other hormone balance such as estrogen and not dht itself?

 

[UberBaldaten]

Thank you Indeed it is interesting. So, do you think that side effects occur due to disorder of other hormone balance such as estrogen and not dht itself?

I don't understand your question.

But I can't give you one answer that will answer them all. It depends on genetics and your hormones. If your hormones are intact and fine, and you have male characteristics, then you could assume you can avoid side effects.

I remember I saw studies where people were without 99% DHT and they had no sides. There is also biological model of humans who do not have DHT and they have sexual drive.

So yes, I think something else is going on with the sides. Erectile Dysfunction is a disorder that is caused by a lot of symptoms, starting from psyche such as depression and anxiety, low testosterone, or high estrogen, or low androgen sensitivity, to blood pressure, diabetes, various neuropathies, all the way to cancer.

 

[Saulus]

I don't understand your question.

But I can't give you one answer that will answer them all. It depends on genetics and your hormones. If your hormones are intact and fine, and you have male characteristics, then you could assume you can avoid side effects.

I remember I saw studies where people were without 99% DHT and they had no sides. There is also biological model of humans who do not have DHT and they have sexual drive.

So yes, I think something else is going on with the sides. Erectile Dysfunction is a disorder that is caused by a lot of symptoms, starting from psyche such as depression and anxiety, low testosterone, or high estrogen, or low androgen sensitivity, to blood pressure, diabetes, various neuropathies, all the way to cancer.

"
A growing body of research is offering clues about why finasteride might cause these symptoms in a subset of men. It suggests the enzyme that Propecia shuts down—5-alpha-reductase—does a lot more than convert testosterone to the hair-killing dihydrotestosterone (DHT). It also converts hormones like cortisol and progesterone into "neurosteroids" that play key roles in the brain.

"Blocking 5 alpha-reductase to any degree in the brain is a crapshoot," says Alan Jacobs, a New York–based neuroendocrinologist. "Theoretically, you are going to block the production of hormones that serve very important behavioral purposes.""

https://tonic.vice.com/en_us/articl...y-behind-americas-best-selling-hair-loss-drug

 

[AnxiousAndy]

You are japanese? You should keep up with your studies and become good doctor one day.

 

[Johnmpb]

I've gone through a lot of information on these boards but I don't consider myself an expert by any means. From my understanding there is no way to measure follicular dht levels without removing the entire follicular unit. The studies that have shown up on these boards typically show "scalp skin dht." The very educated user that used to post here, Bryan (rip), used to say scalp skin dht levels in these various studies were a useless number because they varied so much.

5 alpha reductase type 2 is the main enzyme found in the hair follicles. Finasteride decreases 5ar type 2 by 90%+.

Personally I would not go below .2mg per day. However, u seemed way more educated on thus subject than me.

Can you explain why you decides to add ru58841 to ur regimen of finasteride, minoxidil, and nizoral? Seems a little drastic as a nw2. Can you please describe how you will use ru? How much per day and in what areas of the scalp?

Thank u and good luck

 

[Daiki]

I don't understand your question.

But I can't give you one answer that will answer them all. It depends on genetics and your hormones. If your hormones are intact and fine, and you have male characteristics, then you could assume you can avoid side effects.

I remember I saw studies where people were without 99% DHT and they had no sides. There is also biological model of humans who do not have DHT and they have sexual drive.

So yes, I think something else is going on with the sides. Erectile Dysfunction is a disorder that is caused by a lot of symptoms, starting from psyche such as depression and anxiety, low testosterone, or high estrogen, or low androgen sensitivity, to blood pressure, diabetes, various neuropathies, all the way to cancer.

Thank you Actually, I am the same idea. I studied various things before making this decision, but in fact it came to think that this side effect was not nonsense. As others show, I believe it is true and true that the reduction of neurosteroids is causing side effects. However, from various studies I saw a report that side effects continued after discontinuation of taking placebo,
And I read various books and read in books that anxiety, erectile dysfunction, declining memory, IQ decline, depression are symptomatic with conceit. There are things that have effect on placebo as well, and if you believe that you are sucking oxygen, for example, the subject shows a reaction with oxygen, but the actual oxygen concentration has not changed. The same can be said to hormones.
And I also read that brains change with placebo. I am a hypothesis because it is neither a doctor nor genetics, but if it is supposed that finasteride is decreasing neurosteroids, everyone should have at least some discomfort. However, I also saw some people who do not have any abnormality even if they take more than 10 years. (I do not know because I am self-reported) So, to prove that my opinion is correct, does the neurosteroid decrease in placebo? Before and after finasteride

 

[Daiki]

I found this one

http://onlinelibrary.wiley.com/doi/...nticated=false&deniedAccessCustomisedMessage=


http://www.ncbi.nlm.nih.gov/pubmed/21176115



http://www.ncbi.nlm.nih.gov/pubmed/12639651



http://www.sciencedirect.com/science/article/pii/S0960076017301024

 

[Daiki]

"
A growing body of research is offering clues about why finasteride might cause these symptoms in a subset of men. It suggests the enzyme that Propecia shuts down—5-alpha-reductase—does a lot more than convert testosterone to the hair-killing dihydrotestosterone (DHT). It also converts hormones like cortisol and progesterone into "neurosteroids" that play key roles in the brain.

"Blocking 5 alpha-reductase to any degree in the brain is a crapshoot," says Alan Jacobs, a New York–based neuroendocrinologist. "Theoretically, you are going to block the production of hormones that serve very important behavioral purposes.""

https://tonic.vice.com/en_us/articl...y-behind-americas-best-selling-hair-loss-drug

Thank you

I first realized that many of the people with type 2 5a lactase deficiency are infertile. Thank you

 

[Daiki]

You are japanese? You should keep up with your studies and become good doctor one day.

Than you

I am ready to post a passage on this site, but I do not understand it because I am lazy. hahahaha

 

[Daiki]

I've gone through a lot of information on these boards but I don't consider myself an expert by any means. From my understanding there is no way to measure follicular dht levels without removing the entire follicular unit. The studies that have shown up on these boards typically show "scalp skin dht." The very educated user that used to post here, Bryan (rip), used to say scalp skin dht levels in these various studies were a useless number because they varied so much.

5 alpha reductase type 2 is the main enzyme found in the hair follicles. Finasteride decreases 5ar type 2 by 90%+.

Personally I would not go below .2mg per day. However, u seemed way more educated on thus subject than me.

Can you explain why you decides to add ru58841 to ur regimen of finasteride, minoxidil, and nizoral? Seems a little drastic as a nw2. Can you please describe how you will use ru? How much per day and in what areas of the scalp?

Thank u and good luck

Thank you I saw various articles related to it, but I still do not know what follicle is still. Using the translation function will be messed up I have read all his postings He is extravagant but at least he is not an expert, is it? He said "Scalp dht is totally meaningless and useless" But I think So why are experts smarter than himself showing scalp dht in research papers such as finasteride and dutasterido? Of course, if you know the follicular dht it will all be resolved, but that is difficult However, I think scientists are not meaningless and not useful for studying the scalp dht in research, because the reason for investigating is meaningless and useless Follicle

I think that it is necessary, showing a hir loss improvement close to that if there is no scale below follicular dht

Also, I heard that people with alopecia are twice as high as normal scalp dht.

I do not know how strong it is for 0.05 mg of finasteride alone. So I added ru. Because I do not want to waste time during the experiment with 0.05 mg.


As for ru, I often do not know but ru has heard that the effect range is wide, so I'm planning to do the middle of the hairline and the tsunzu But I have not seen ru's improvement, so I do not expect it I do not know the amount Twice a day Minoxidil only Nizoral is scheduled once every 3 days Thanks brothers

 

[Johnmpb]

Thank you I saw various articles related to it, but I still do not know what follicle is still. Using the translation function will be messed up I have read all his postings He is extravagant but at least he is not an expert, is it? He said "Scalp dht is totally meaningless and useless" But I think So why are experts smarter than himself showing scalp dht in research papers such as finasteride and dutasterido? Of course, if you know the follicular dht it will all be resolved, but that is difficult However, I think scientists are not meaningless and not useful for studying the scalp dht in research, because the reason for investigating is meaningless and useless Follicle

I think that it is necessary, showing a hir loss improvement close to that if there is no scale below follicular dht

Also, I heard that people with alopecia are twice as high as normal scalp dht.

I do not know how strong it is for 0.05 mg of finasteride alone. So I added ru. Because I do not want to waste time during the experiment with 0.05 mg.


As for ru, I often do not know but ru has heard that the effect range is wide, so I'm planning to do the middle of the hairline and the tsunzu But I have not seen ru's improvement, so I do not expect it I do not know the amount Twice a day Minoxidil only Nizoral is scheduled once every 3 days Thanks brothers

Daiki
I understand the translation can be quite difficult as English and Japanese are very different languages but you are doing quite well. I think what Bryan meant by the "scalp DHT is useless" because the studies had such different results so it made really no sense to try and interpret the results. For example, if one study shows 60% reduction in scalp DHT and another shows only 20% but hair still improves in the study population there is not much we can interpret regarding scalp DHT from these studies. I hope this makes sense.

How much ru will you be using per day? 1ml? Also, what do u think of using ru which comes from unknown Chinese sources. It makes me uncomfortable in terms of safety.

 

[Daiki]

Daiki
I understand the translation can be quite difficult as English and Japanese are very different languages but you are doing quite well. I think what Bryan meant by the "scalp DHT is useless" because the studies had such different results so it made really no sense to try and interpret the results. For example, if one study shows 60% reduction in scalp DHT and another shows only 20% but hair still improves in the study population there is not much we can interpret regarding scalp DHT from these studies. I hope this makes sense.

How much ru will you be using per day? 1ml? Also, what do u think of using ru which comes from unknown Chinese sources. It makes me uncomfortable in terms of safety.

Thank you I also studied variously, but I also know that although there are errors in research, they are almost the same But, since I think that I do not know yet, do you have that proof? I need it. Also, it did not make sense even if examining the amount of hair of 1 mg and 0.2 mg According to this Japanese study 1 mg is more than 0.2 mg Also, it did not make sense even if examining the amount of hair of 1 mg and 0.2 mg According to this Japanese study 1 mg was better than the self assessment of 7 questions than 0.2 mg, but it is not self-assessment to the last but the hair volume. So, we need accurate data As you are sure it is uncomfortable and dangerous But I can not help because there are no other options besides that