- Reaction score
- 294
Okay guys so I have finally gotten my DNA test results back and I've lined up my genes to this study I've done, this is all looking very promising and indicates a positive effect for stepping up to dutasteride. I'm planning to implement it once a week with finasteride at this point.
www.ncbi.nlm.nih.gov
Genes I have -
rs1128977 (Good Gene) rs1128977 on RXRG is associated with response to dutasteride.
rs3822430 (Good Gene) The product of SRD5A1 is type I 5AR, which is a target of dutasteride. (infers superior results on dutasteride over finasteride which is 5AR-II)
rs2241057 (Bad Gene) CYP26B1 is able to inactivate both all-trans-RA and 9-cis-RA (retinoic acid)
The negative gene I have isn't that overly impactful whereas the others I dont have act as backdoors which make dutasteride almost useless. Overall based on my genes this is all very promising for a good response to dutasteride.
A concerning factor is that I have a lot of genes that predispose me to both prostate and breast cancer so I'll have to be conscious of that to be safe.
![www.ncbi.nlm.nih.gov](/interact/proxy.php?image=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fcorehtml%2Fpmc%2Fpmcgifs%2Fpmc-card-share.jpg%3F_%3D0&hash=8b55bcc3f2239d8f6c02ac8c7be7f6f4&return_error=1)
Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
Dutasteride, a dual inhibitor of both type I and II 5α-reductases, is used to treat male pattern hair loss (MPHL). However, patient response to dutasteride varies in each individual, the cause of which is yet to be identified. To identify genetic ...
![www.ncbi.nlm.nih.gov](/interact/proxy.php?image=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fcoreutils%2Fnwds%2Fimg%2Ffavicons%2Ffavicon.png&hash=7603ce0a4f9ff79cf399828718fba8a5&return_error=1)
rs1128977 (Good Gene) rs1128977 on RXRG is associated with response to dutasteride.
rs3822430 (Good Gene) The product of SRD5A1 is type I 5AR, which is a target of dutasteride. (infers superior results on dutasteride over finasteride which is 5AR-II)
rs2241057 (Bad Gene) CYP26B1 is able to inactivate both all-trans-RA and 9-cis-RA (retinoic acid)
The negative gene I have isn't that overly impactful whereas the others I dont have act as backdoors which make dutasteride almost useless. Overall based on my genes this is all very promising for a good response to dutasteride.
A concerning factor is that I have a lot of genes that predispose me to both prostate and breast cancer so I'll have to be conscious of that to be safe.