Hormone Replacement Therapy Reverted My Androgenetic Alopecia | Page 4 | HairLossTalk Forums

Hormone Replacement Therapy Reverted My Androgenetic Alopecia

Discussion in 'Success Stories' started by chillvisio, Aug 31, 2016.

  1. chillvisio

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    Sadly, that's the case. There are no safe meds.
    Cypro - risk of liver damage, pituitary tumor
    spironolactone - risk of hyperkalemia, kidney damage (on the long run), high levels of uric acid
    Bicalutamide - risk of heart failure
    The safest meds like Leuprorelin are unaffordable on the long run.
     
  2. chillvisio

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  3. DHTpolice

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    Wow, your hair is much thicker than before. My hair is identical, same color and texture, I hope estradiol will help me with density too. Don't want to use minoxidil ever. Do you think 2 mg E daily is enough to maintain T in low female range, while also being on spironolactone and low dose cypro?

    Have you experienced inflamation when hair loss started, itch and burning sensation? Did estradiol help with it? Thanks in advance.
     
    #63 DHTpolice, Sep 16, 2017
    Last edited: Sep 16, 2017
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  4. chillvisio

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    Having some sex hormones in your body while suppressing you endogenous hormones is basically a great idea. I mean it's good for your overall health and especially for bone mineral density.
    We both know that it's always YMMV, but estradiol will probably make your hair thicker. If spironolactone didn't help for that, estradiol will possibly grow you a pair of nice boobs (if you're okay with having boobs, which are secondary sex characteristic of females, it's a win-win situation). It will also feminize your face and body to certain extent. If you don't remove your facial hair you will not have a boy fail. With facial hair permanently removed and some make up on you will possibly not pass as a boy. Everything depends on whether you want your boy mode to fail or not :)
    Even 2mg of sublingual Estrace/Estrofem alone will be able to suppress your T to certain extent, but should you add 12.5mg of cypro or 100mg of spironolactone, you'll have better chances to have your T in female range and your E2 in pre-menopausal range. With that of a dose, don't expect too high of an estradiol level, probably somewhere around 50pg/ml which is perfectly in male range and probably not enough for preserving your bone density, but it will be best to have some blood work done at 3 months on HRT to see how your E2 and T levels changed. Some people achieve high E2 levels even with that of a low dose.

    I've experienced constant scalp itching since the onset of my puberty. This itching was always there pre-transition. Maybe it's related to sebum, I don't know, but now I don't have it and my skin barely secretes some tiny quantities of sebum when its like 95°F or more outside. I may not wash my hair for a week and beside it becomes less curly 4 or 5 days without washing it, it's still as dry as it used to be after washing it.

    P.S/ Я сейчас увидела, что Вы из России. У меня информации, что там можнo только прогинова купить, а, прогинову не можно принимать сублингвально, а только PO.
     
    #64 chillvisio, Sep 16, 2017
    Last edited: Sep 16, 2017
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  5. DHTpolice

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    Ok, thanks for the information. I will try 2 mg of Progynova for the first year, and then maybe switch to 4 mg daily. I don't mind to have brests if it helps me with hair regrowth. I consider it as a trade-off. Also I hate male's second sexual characteristics, they do not suit me at all, only making me uglier and older. When beard started appearing at 18, I was constantly thinking how to prevent it from further developing, but, unfortunately, I knew nothing about androgen deprivation and estrogen therapy at that time. Hair loss didn't bother me then, and I was satisfied with my look after shaving the beard, so I ended my research pretty quickly. But hair loss affected me very badly and rapidly to do nothing with it. I was in denial for 6 months, thought I was vitamin deficient and ill, cause hair loss is not common in family (father is Norwood 1 at 52 with great density, mother is thinner at 48, but probably due to the estrogen decline and her antihypertensive drugs). Fortunately, I came across this site, and learned about 5α-Reductase inhibitors. Strangely enough, but I immediately realized how weak they are. After reading well-known Hamilton's study I chose chemical castration as the most effective and reliable option for treating this desease. Conventional treatment (big 3) is not for me, cause I can't stand the look of mature hairline, even if it Norwood 2.

    I am on finasteride and spironolactone since the beginning of this year, added low dose cypro a bit later. Never checked my hormonal profile, but I suppose my T is low, but not in female range yet, cause my receptors are still under the significant androgen stimulation (itch and oiliness are not gone completely). Brain detects a low level of testosterone and produce LH, which, in turn, sends signal to testicles to produce even more T. I hope, 2 mg of E will be enough to achieve estrogen dominance and brain will stop that cascade of processes. Time will tell.

    P. S. Да, в России и Украине в продаже доступен только эстрадиола валерат (Progynova). Я в курсе, что его следует принимать перорально, но спасибо за предупреждение. Всё же я бы предпочёл Estrofem, он гораздо эффективнее усваивается и имеет более выраженный эффект. Возможно, я буду заказывать Estrofem с AllDayChemist, когда мой доход немножко стабилизируется. Но пока что в плане экономии и доступности Progynova более рациональный выбор для меня.
     
    #65 DHTpolice, Sep 17, 2017
    Last edited: Sep 17, 2017
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  6. ManinBlack

    ManinBlack Experienced Member My Regimen

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    Have you considered getting your entire beard transplanted to your head as opposed to electrolysis? There are some hair transplant surgeons that do beard transplants. Might as well kill 2 birds with one stone.
     
  7. DHTpolice

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    Yes, it would be a great idea (only if the hair from beard will look similiar with the head's hair), but I prefer to consider hairline feminization surgery instead of traditional hair transplant and only as a last resort. Estrogen and antiandrogens should take care of thinning all over. Ok, will not hijack the thread.
     
  8. yourworld001

    yourworld001 Established Member

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    Are you transgender? want you become a women?
     
  9. chillvisio

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    You're definitely not cis.

    It was 1998 when I was 18 and sadly the only trans person that I knew of was the Israeli singer Sharon Cohen (Dana International) and I didn't have any idea how she managed to have such a feminine body and face :)

    5AR-inhibitors tend to work for some and not for others. And their safety profile is questionable, not that CPA or spironolactone have a better safety profile. Chemical castration on the other hand is not a long term option, because you risk to have your liver or kidneys damaged. With some trans people 6mg of sublingual estradiol seems to be enough to cause negative feedback on the HPG axis once the E2 levels are in female ranges. But starting with 2mg and not increasing the dose until a few months had passed will promote normal breast development (if it matters to you).

    While finasteride and low doses of spironolactone do not induce negative feedback in HPG axis, cypro does so. I don't know what's your dosage of cypro, but 50mg alone will most probably knock down your T production in a matter of 3 weeks, then you could lower the dose and add E2 and your T will still not increase. I've been on spironolactone+cypro together for 1 month while removing spironolactone from my regimen. I haven't made any blood work since April.
     
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  10. yourworld001

    yourworld001 Established Member

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    Why you disliking questions I ask, they are genuine.
     
  11. DHTpolice

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    Most probably I am not cis, but at the moment I will try to stay androgynous as long as possible, because I am living with parents, and they are ultra-conservative. I don't fear them at all, I even recently told them I am a non-binary transgender to get their reaction, they are laughed at me, that's it. But full blown transition to female is currently not an option for me, even despite the fact I would pass as a female without too much work.

    I know, chemical castration drugs for long-term use is not good for health. Nevertheless, on eunuchs.org there are many cases of those who are living with undetectable T for decades without E and still not experiencing any health issues. I am taking 12.5 mg of cypro eod since March, now taking that dose every day.
     
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  12. chillvisio

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    I can really understand your concerns, myself living in a so called conservative country, where most people find it normal to make fun of sb for being homosexual or trans. I had the luck to be accepted by my family, but rejected by the uncle I used to love so much. So in your case looking androgynous while living with your parents is the better choice.

    I'm a member of that forums as well and they were very helpful at the beginning of my transition. I see that there is really an eunuch culture and lost of members just avoid any feminization and are doing fine. There are also some trans people who are helpful as well.
    12.5mg of CPA is a really not that high of a dose, so I think it won't be too damaging for the liver in the long run. It equals to the CPA found in like 6 pills of Diane-35.
     
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  13. folfoxorack

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    @chillvisio : I don't know if you have the answer, but who knows.What do you thing about taking 12.5 mg of cypro every 3 days. It will lower testosterone ? Not at all ? Too much ? An idea ?
    Thanks
     
  14. chillvisio

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    CPA's biological half-life is 38h. That means on the 24th hour you'll still have 12.5mg of active substance in your body, on the 48th hour you'll have 6.25mg and on the 72nd hour you should still have abt 6.25mg of CPA in your body. On the the 76th hour you'll theoretically have 3.125mg of it.
    If used alone it will not do magic and will probably not lower your T significantly, but if used with E2 it may have synergistic effect on your T levels.
     
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  15. folfoxorack

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    Hm Ok ... I will test it, and it's not enough I will increase the dosage gradually. Thanks for your input.
     
  16. chillvisio

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    Just in case if you go above 25mg/day, don't forget to also make blood work of your prolactin levels, as CPA tends to promote prolactin secretion increase, which in the long run may lead to a benign pituitary tumor called prolactinoma.
     
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  17. dustovshio

    dustovshio Member

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    Did androcur give u muscle pain in one leg or in the back.
     
  18. dustovshio

    dustovshio Member

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    So what do you think about bicalutamide? I thought it was supposed to be safer than CPA.
     
  19. chillvisio

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    Bicalutamide has hepatotoxicity as side effect as well. If you're a cisgender man, it's the best choice, because it does not block androgen receptors in the brain, so neurological and psychological effects of T will still be there, but if you're a trans person the psychological effects of testosterone might not be well tolerated in the presence of high enough (male range) T levels.

    No, I didn't notice anything like that. But some people taking spironolactone report muscle cramps in the legs which might be due to electrolite imbalance (Potassium/Sodium). Other reason for muscle pain might be muscle loss due to androgen deprivation.
     
  20. folfoxorack

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    I don't think Bicalutamide is a good choice for hair loss and I'm sorry to conclude that ... First it increase testosterone, so DHT as well. Second, it's not as strong as Dutasteride to protect our precious follicles against DHT. I tried 12.5mg, 25, 50 and 100mg of Bicalutamide and itchy scalp was insane, because at the same time I lowered Dutasteride, and Bicalutamide couldn't replace it. As soon as I took back Dutasteride this f@*%£ing itchy scalp ... was gone, and my libido with it, unfortunately.
    Bicalutamide is good against Testosterone, not strong enough against DHT, at average dose.
    I tried Cyproterone with Bica (12.5mg, 25mg and 50) ... my balls shrank a lot, a lot more than with 100 spironolactone actually. And they are still pretty small with 12.5mg every other day now ... it's pretty strong. But still not enough against DHT ...
    I think Cypro+Bica should be avoided. If Finasteride doesnt help, go to Dutasteride 0.5mg, if it's not enough, try something like 3 pills every 3 days ... Yeah from my experience is not like 1 pill a day. It doesn't really make sense, but it works like that. I have quicky itchy scalp when my DHT is coming back stronger, so I always know when I have to lower it to protect my hair. When I take duta, after a day itchy scalp disappears.
    And if you're trans mtf on treatment and still losing your hair ... take dutasteride, a lot of trans do that, even if they have almost no testosterone. Dutasteride will protect your hair, and Estradiol will your hair grow.
     
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