Hinokitiol, inhibits TNF-alpha production via NF-kappaB

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bornthisway

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Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-alpha Production in LPS-Activated Macrophages via Suppression of NF-kappaB.

Planta Med. 2008 Jun 6.
Byeon SE, Lee YG, Kim JC, Han JG, Lee HY, Cho JY.
School of Bioscience and Biotechnology, and the Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea.

In this study, we examined the modulatory effect of hinokitiol (HK) on the production of tumor necrosis factor (TNF)-alpha, a critical factor involved in skin inflammation and hair follicle apoptosis. HK effectively suppressed TNF-alpha production in lipopolysaccharide (LPS)-activated, macrophage-like (RAW264.7) cells. This compound also diminished mRNA synthesis of TNF-alpha, indicating that HK-mediated inhibition may occur at the transcriptional level. Moreover, this compound down-regulated the phosphorylation of PDK1, Akt/PKB, and ERK, resulting in a loss of nuclear factor (NF)-kappaB activation, which is detectable by immunoblotting and reporter gene assays. Therefore, these results suggest that HK may cure hair loss by suppressing factors that promote follicular apoptosis, such as TNF-alpha, in addition to stimulating new hair growth.

PMID: 18537078
 
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bornthisway

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In vivo hair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly(?-caprolacton) nanocapsules

Journal of Microencapsulation. 17 March 2008.
S. L. Hwang; J. -C. Kim.
Affiliations: LG Household ?&?Health Care, Yusong-gu, Taejon, Korea
School of Biotechnology ?&?Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University, Chunchon, Kangwon-do, Korea

Abstract
Nanocapsules containing hinokitiol (HKL) were prepared by an emulsion-diffusion method. In an emulsification step in preparing nanocapsules, cetyltrimethylamonium chloride (CTAC) was employed as a cationic emulsifier, Poly(?-caprolactone) (PCL) was use as a wall material and HKL dissolved in octylsalicylate (OS) was used as a core material. The submicron-sized nanoparticle was observed on a TEM. The size ranged 55-234 nm and the mean diameters were 223 nm, which were determined by a dynamic light scattering method. According to the results of pH-dependent microelectrophoresis, the absolute value of the surface potential of the nanocapsules was greater than 20 mV. The nanocapsules were colloidally stable over the pH range of 3-11. The nanocapsules were included in two kinds of preparations, namely shampoo and hair tonic, and the preparations were applied every day for 3 weeks on the clipped backs of 6 week-old mouse (C57BL/6) to investigate the hair growth-promoting effect. The degree of hair growth was evaluated by image-analysing the photographs of the backs and, in parallel, by the histological observation of the formation and the growth of hair or hair bulbs. The results were compared with those of commercially available Minoxidil solution (3%). Phosphate buffered saline was used as a control. The in vivo hair growth-promoting effects of the two preparations were comparable to those of Minoxidil solution. These results are in a good agreement with the histological and structural changes of follicles of the model animals, of which skins were treated with either the testing samples or the control in the same way the experiments of in vivo hair growth promotion were performed.
Keywords: Hinokitiol; nanocapsules; cosmetics, in vivo hair growth promotion
 
el_duterino

el_duterino

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I have bought and already received a 500ml bottle of natural Hinoki oil.This stuff stinks a bit, it is a clear oily liquid.
Have not tried it on my scalp yet.
 
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