High IGF-1 levels correspond to greater success with finasteride

[5minutesbeforemiracle]

The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia - PubMed

In a small uncontrolled study of 9 patients with Androgenetic Alopecia, an increased expression of IGF-1 messenger RNA levels in the DP was associated with patient response to finasteride.

pubmed.ncbi.nlm.nih.gov

So how do we increase IGF-1? Suplementing with selenium and/or coenzyme q10 are some ways:

Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

Insulin-like growth factor-1(IGF-1) has a multitude of effects besides cell growth and metabolism. Reports also indicate anti-inflammatory and antioxidative effects. The concentrations of IGF-1 decrease with age and during inflammation. As selenium and ...

www.ncbi.nlm.nih.gov

Supplementing with zinc also helps:

The influence of zinc supplementation on IGF-1 levels in humans: A systematic review and meta-analysis

The effect of supplementation with zinc on levels of IGF-1 remains relatively unexplored, and many of previous studies have reported equivocal finding…

www.sciencedirect.com

Microneedling increases IGF-1 locally.

Comprehensive molecular characterization of microneedling therapy in a human three‐dimensional skin model

Background and objectives Microneedling therapy is a widely used technique in dermatology. However, little is known about the underlying molecular effects of this therapy on extracellular matrix remodeling, wound healing, and inflammation. The aim of this study was to examine morphological and...

journals.plos.org

Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin | Request PDF

Request PDF | Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin | Non-melanoma skin cancer primarily affects geriatric patients as evidenced by the fact that only 20% of these cancers are diagnosed in patients... | Find, read and...

www.researchgate.net

Let's discuss.

 

[BabyFineHair]

HGH, Ipamorelin etc, also testosterone increased my IGF1 substantially

 

[Biffy]

MK-677, oral IGF-1.

 

[Baldingtooyoung]

Upregulated IGF-1 is correlated with cancer growth. Not a long-term viable solution imo.

 

[Moz5x]

The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia - PubMed

In a small uncontrolled study of 9 patients with Androgenetic Alopecia, an increased expression of IGF-1 messenger RNA levels in the DP was associated with patient response to finasteride.

pubmed.ncbi.nlm.nih.gov

So how do we increase IGF-1? Suplementing with selenium and/or coenzyme q10 are some ways:

Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

Insulin-like growth factor-1(IGF-1) has a multitude of effects besides cell growth and metabolism. Reports also indicate anti-inflammatory and antioxidative effects. The concentrations of IGF-1 decrease with age and during inflammation. As selenium and ...

www.ncbi.nlm.nih.gov

Supplementing with zinc also helps:

The influence of zinc supplementation on IGF-1 levels in humans: A systematic review and meta-analysis

The effect of supplementation with zinc on levels of IGF-1 remains relatively unexplored, and many of previous studies have reported equivocal finding…

www.sciencedirect.com

Microneedling increases IGF-1 locally.

Comprehensive molecular characterization of microneedling therapy in a human three‐dimensional skin model

Background and objectives Microneedling therapy is a widely used technique in dermatology. However, little is known about the underlying molecular effects of this therapy on extracellular matrix remodeling, wound healing, and inflammation. The aim of this study was to examine morphological and...

journals.plos.org

Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin | Request PDF

Request PDF | Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin | Non-melanoma skin cancer primarily affects geriatric patients as evidenced by the fact that only 20% of these cancers are diagnosed in patients... | Find, read and...

www.researchgate.net

Let's discuss.

Thanks for posting this. I guess micro needling is the safest way to upregulate then? I’ve read so many mixed reviews regarding zinc supplementation and hair loss I don’t know what to think anymore.

 

[Doingitright]

Mk677 is an option but ultimately it is a research chem with various possibly serious sides, but it does what it says on the tin and is easily available.

Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191; former tentative brand name Oratrope) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.[3][4][5][6][7] It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.[8]

Ibutamoren has been shown to sustain activation of the GH–IGF-1 axis and to increase lean body mass with no change in total fat mass or visceral fat. It is under investigation as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,[3][9][10][11] and human studies have shown it to increase both muscle mass and bone mineral density,[12][13] making it a promising potential therapy for the treatment of frailty in the elderly.[14][15] As of June 2017, ibutamoren is in the preclinical stage of development for growth hormone deficiency.[3]

 

[5minutesbeforemiracle]

Upregulated IGF-1 is correlated with cancer growth. Not a long-term viable solution imo.

This is a good point.
This article here proposes the different mechanisms by which IGF-1 could (theoretically) possibly promote cancer.

Mechanisms by which IGF-I May Promote Cancer

Multiple large case-control studies in the past five years have reported positive associations between high circulating levels of the insulin-like growth factor (IGF)-I and risk for different types of cancer. Correlations certainly do not prove causation, ...

www.ncbi.nlm.nih.gov

Unfortunately, a lot of the info went over my head as it's quite technical. Is anyone able to have a look at this and theorise if increasing IGF-1 in the methods proposed in the OP post are applicable to this article here?

 

[HansMetjen]

Upregulated IGF-1 is correlated with cancer growth. Not a long-term viable solution imo.

True.

"Micro-Dosing" might be the way to go?

 

[HansMetjen]

Mk677 is an option but ultimately it is a research chem with various possibly serious sides, but it does what it says on the tin and is easily available.

Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191; former tentative brand name Oratrope) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.[3][4][5][6][7] It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.[8]

Ibutamoren has been shown to sustain activation of the GH–IGF-1 axis and to increase lean body mass with no change in total fat mass or visceral fat. It is under investigation as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,[3][9][10][11] and human studies have shown it to increase both muscle mass and bone mineral density,[12][13] making it a promising potential therapy for the treatment of frailty in the elderly.[14][15] As of June 2017, ibutamoren is in the preclinical stage of development for growth hormone deficiency.[3]

What about Ipamorelin?