Has Anyone Ever Tried Sphinganine ?

[DavidHHT]

I found something very interesting in a clinical trial about Sphinganine and Finasteride.

The enzyme 5-α-reductase directly causes hair loss in both
males and females.Thus, to determine whether sphinganine has an inhibitory potential toward 5-α-reductase type I, IC50 values were determined in a cell-free assay using cell homogenates isolated from stably transfected human embryonic kidney cells. The IC50 for sphinganine, determined in two independent experiments, 6.5±0.33 and 6.8±0.1 μM, while the control finasteride showed an IC50 of 0.42±0.02 μM. The results indicate that sphinganine is a suitable ingredient to inhibit 5-α-reductase and thus prevent the conversion of testosterone to dihydrotestosterone (DHT).

Now, i return to the tittle and the question, has anyone ever tried Sphinganine?

 

[GoldenMane]

If it does work, is there any reason to choose it over finasteride? If it does the same thing then I imagine it would have the same side effects profile...

 

[DavidHHT]

From what i know for Finasteride / Propecia you need prescription instead for this no, from this i can understand may not be the same side effects

 

[whatevr]

Test was done in vitro so, no evidence to suggest it works the same way inside a human body.
No regards to necessary dose, where to obtain it, what the cost is, and safety profile of this molecule in its entirety.
Lots of things to consider.