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pegasus2

Senior Member
My Regimen
Re; instablility of PGE2. Why not use ricinoleic acid instead of PGE2: good stability and much cheaper?

I'm not concerned about the cost difference. PGE2 is more potent, and stability isn't an issue in the right vehicle when you make a new batch every 1-2 weeks. I doubt it's even a big issue at one month. There's just no way ricinoleic acid is going to work as well as PGE2 when it only works on EP3 and EP4 receptors. PGE2 activates EP1-4 and FP. EP2, EP4, and FP are the most beneficial. EP3 might be a negative regulator of hair growth due to downregulating cAMP.
 

Obsessive

Experienced Member
My Regimen
I'm not concerned about the cost difference. PGE2 is more potent, and stability isn't an issue in the right vehicle when you make a new batch every 1-2 weeks. I doubt it's even a big issue at one month. There's just no way ricinoleic acid is going to work as well as PGE2 when it only works on EP3 and EP4 receptors. PGE2 activates EP1-4 and FP. EP2, EP4, and FP are the most beneficial. EP3 might be a negative regulator of hair growth due to downregulating cAMP.
Your theory is sound, however the effect of drinking castor oil on hair is significant so it can't be denied that ricinolic acid works very well, regardless of its pharmacological profile. Theory doesn't always equate to practice. It would be great if someone who has experience with PGE2 did a comparison to ricinoleic acid.
 

Obsessive

Experienced Member
My Regimen
What vehicle?
Water, ethanol, glycerol (minoxidil max non-PG forumula). I also add bicalutamide to this but its only soluble up to 5 mg/mL-that's too weak I'm afraid. I'm going to make a more concentrated bica solution as soon as my DMSO arrives.
 

pegasus2

Senior Member
My Regimen
Your theory is sound, however the effect of drinking castor oil on hair is significant so it can't be denied that ricinolic acid works very well, regardless of its pharmacological profile. Theory doesn't always equate to practice. It would be great if someone who has experience with PGE2 did a comparison to ricinoleic acid.

I haven't seen where people have had success with it, but I don't doubt it. I believe it works topically, but I see no reason to use it over PGE2 except cost. This is about getting hair, not saving money.
 

Stephen788

Established Member
My Regimen
I haven't seen where people have had success with it, but I don't doubt it. I believe it works topically, but I see no reason to use it over PGE2 except cost. This is about getting hair, not saving money.

what is the cost of your regimen? I can afford to do this but I’m also saving for a house so I’ll need to be careful not to over spend lol
 

pegasus2

Senior Member
My Regimen
what is the cost of your regimen? I can afford to do this but I’m also saving for a house so I’ll need to be careful not to over spend lol

I've never bothered to figure out exactly how much it costs me, but it's not really cheap. Here's some of the prices you can expect to pay, plus transaction fees.
 

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Obsessive

Experienced Member
My Regimen
I've never bothered to figure out exactly how much it costs me, but it's not really cheap. Here's some of the prices you can expect to pay, plus transaction fees.
Wow! No one can deny your dedication.

In terms of RA vs PGE2, I think there are pros and cons for each. If you can confirm that you are actually receiving and using the chemical you are buying AND you can afford PGE2 in the first place, then perhaps it makes more sense. Also, there are no success stories behind using RA topically yet (although it definitely seems to work with systemic administration, which tells me it should work topically if it can reach the follicle).

Have you found that any of the peptides you use have a local effect with SQ scalp injection? Seems like spot treatment injections could be beneficial for problem areas.
 

pegasus2

Senior Member
My Regimen
Wow! No one can deny your dedication.

In terms of RA vs PGE2, I think there are pros and cons for each. If you can confirm that you are actually receiving and using the chemical you are buying AND you can afford PGE2 in the first place, then perhaps it makes more sense. Also, there are no success stories behind using RA topically yet (although it definitely seems to work with systemic administration, which tells me it should work topically if it can reach the follicle).

Have you found that any of the peptides you use have a local effect with SQ scalp injection? Seems like spot treatment injections could be beneficial for problem areas.

I haven't noticed any RA results. I've seen some good results from topical castor oil. It should be too heavy to work, but it seems to. If that works then RA should work.

No, I don't do scalp injections. @John Difool does.
 

John Difool

Senior Member
My Regimen
Some Peptides do a better job locally than others. PTD-DBM and IGF-1 are my scalp cocktail right now. HGH Copper TB-500 and BPC 157 I inject subq abdominal. The rest I do IM.
 

Analogies

Member
My Regimen
So it begins....

+ Finasteride and maybe a small oral dose of minoxidil
 

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John Difool

Senior Member
My Regimen
They make salt based powders to ship in summer because it'd more stable with heat. They may have left over stock to get rid of before making new batches.
 

pegasus2

Senior Member
My Regimen
Can anyone confirm if there is a huge difference between the two PGf2a molecules below? Wuhan says they only have
Prostaglandin F2α (tromethamine salt) in stock. I'm only seeing that the salt is more water soluble and has a heavier molecular weight.
https://www.caymanchem.com/product/16020/prostaglandin-f2α-(tromethamine-salt)
https://www.caymanchem.com/product/16010

Not really. Like John said, more stability. Slightly less potency per gram due to the salt content.
 

dgadgdea

Member
My Regimen
useful reading thanks. States that cetirizine is a PGD2 inhibitor which I understand to be a different mechanism of action than something like latanoprost which works on PGF2A
 
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