Been telling everybody on here that I saved my hair from Androgenic Alopecia with Miconazole Nitrate.. Here is another fact that MN is bad *** and should be added to your daily minoxidil regimen..
MN inhibit some P450 enzymes.. and it is the strongest inhibitor of CYP2C9..according to this study.
Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes.
Niwa T,
Shiraga T,
Takagi A.
Source
Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
toshiro.niwa@jp.astellas.com
Abstract
The effects of five antifungal drugs, fluconazole, itraconazole, micafungin, miconazole, and voriconazole, on cytochrome P450 (CYP) 2C9-mediated tolbutamide hydroxylation, CYP2C19-mediated S-mephenytoin 4'-hydroxylation, and CYP3A4-mediated nifedipine oxidation activities in human liver microsomes were compared. In addition, the effects of preincubation were estimated to investigate the mechanism-based inhibition. The IC50 value against tolbutamide hydroxylation was the lowest for miconazole (2.0 microM), followed by voriconazole (8.4 microM) and fluconazole (30.3 microM). Similarly, the IC50 value against S-mephenytoin 4'-hydroxylation was the lowest for miconazole (0.33 microM), followed by voriconazole (8.7 microM) and fluconazole (12.3 microM). On the other hand, micafungin at a concentration of 10 or 25 microM neither inhibited nor stimulated tolbutamide hydroxylation and S-mephenytoin 4'-hydroxylation, and the IC50 values for itraconazole against these were greater than 10 microM.
These results suggest that miconazole is the strongest inhibitor of CYP2C9 and CYP2C19, followed by voriconazole and fluconazole, whereas micafungin would not cause clinically significant interactions with other drugs that are metabolized by CYP2C9 or CYP2C19 via the inhibition of metabolism. The IC50 value of voriconazole against nifedipine oxidation was comparable with that of fluconazole and micafungin and higher than that of itraconazole and miconazole. The stimulation of the inhibition of CYP2C9-, CYP2C19-, or CYP3A4-mediated reactions by 15-min preincubation was not observed for any of the antifungal drugs, suggesting that these drugs are not mechanism-based inhibitors.
and according to this study:
In summary, inhibiting CYP 2C9 significantly improves
NO-mediated vasodilatation..
Which will greatly boosts an enhances the benefits of Minoxidil.
http://circ.ahajournals.org/content/109/2/178.full.pdf
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Cool thread on MSM:
http://immortalhair.forumandco.com/...nd-high-amounts-msm-orally-look-this-pictures
. oh and i forgot to say i also go with 10 cm long hair which i am not going to cut shorter lol
