Garlic works by the same mechanism of action as minoxidil

[Norwood-null-by-2021]

Garlic opens the potassium channels. It is EXACTLY the same principle of action as Minoxidil and even significantly better.
Then why do people take minoxidil when garlic works so much better?

 

[Flamingflaps]

No one knows exactly how minoxidil works. It's a drug with a multi-faceted effect; opening potassium channels is just one of its effects and would likely do very little if that is all it did.

 

[Norwood-null-by-2021]

In a study it could be shown that the opening of the Potassium-channels is the main mechanism of action. It is very easy to check. You just have to block the potassium channels and see if minoxidil is still working. Result: NO! Then no longer works.

 

[sonictemples]

Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53 - PubMed

Alliin, a compound derived from garlic, demonstrated dose-dependent inhibition of fibroblast growth factor-2 (FGF2)-induced human endothelial cell (EC) tube formation and angiogenesis in the chick chorioallantoic membrane (CAM) model. Additionally, alliin demonstrated potent inhibition of...

pubmed.ncbi.nlm.nih.gov

Additionally, alliin demonstrated potent inhibition of vascular endothelial growth factor (VEGF)-induced angiogenesis in the CAM model.

 

[Norwood-null-by-2021]

Garlic inhibits DHT (bald wearers have significantly increased DHT levels in the scalp due to the high histamine levels):

Anti-Proliferation Effects of Garlic (Allium sativum L.) on the Progression of Benign Prostatic Hyperplasia - PubMed

Benign prostatic hyperplasia (BPH) is a urologic disease that affects most of men over the age 50. But until now there is no such perfect cure without side effects. Because of diverse adverse effects, it is desirable to develop effective and long term-safety-herbal medicines to inhibit the...

www.ncbi.nlm.nih.gov

Enzyme Inhibitory Activity of Certain Vegetables Indigenous in Iran as Potential Antiandrogens

ABSTRACT: Androgenetic alopecia is the chief type of scalp hair loss regardless of gender, causing anxiety, depression, arterial stiffness, and cardiovascular disease. The areal parts of Olea europaea (OE) and Trigonella foenum-graecum (TF), as well as the bulbs of Allium sativum (AS) are vastly...

jfbt.srbiau.ac.ir

Garlic inhibits P. acnes (increased levels were observed in subjects with Androgenetic Alopecia):

(PDF) Development and evaluation of anti-acne gel containing garlic (Allium sativum) against Propionibacterium acnes

PDF | Objective: The aim of this study is to develop and evaluate the gel of garlic juice as anti-acne to facilitate the topical usage.Methods: The... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

Garlic works against Malassezia (as well as ketoconazole!). Bald people have significantly increased Malassezia fungi!

In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes - PubMed

By using an agar dilution assay, the antifungal activity of aqueous extracts prepared from Allium cepa (onion; AOE) and Allium sativum (garlic; AGE) were evaluated against Malassezia furfur (25 strains), Candida albicans (18 strains), other Candida sp. (12 strains) as well as 35 strains of...

pubmed.ncbi.nlm.nih.gov

Garlic acts as a potassium channel opener (same principle of action as Minoxidil!) And promotes blood circulation and muscle relaxation:

Allicin, a SUR2 opener: possible mechanism for the treatment of diabetic hypertension in rats

The garlic (Allium sativum L., Amaryllidaceae) has been popularly used in the treatment of...

www.scielo.br

Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil - PubMed

The mechanism by which minoxidil, an adenosine-triphosphate-sensitive potassium channel opener, induces hypertrichosis remains to be elucidated. Minoxidil has been reported to stimulate the production of vascular endothelial growth factor, a possible promoter of hair growth, in cultured dermal...

www.ncbi.nlm.nih.gov

Garlic contains two prostaglandins: A2 and F1a (prostaglandins, except D2, promote hair growth!)

[PDF] Bioassay for prostaglandin-like activity of garlic extract using isolated rat fundus strip and rat colon preparation. | Semantic Scholar

Garlic extract produced the effects on the isolated tissue similar to those of PGE, and the use of this response as a bioassay for prostaglandin is discussed. Hypotensive effect of garlic extract involving releasing of various prostaglandins is well documented. To further evaluate the...

pdfs.semanticscholar.org

Garlic inhibits mast cells and prostaglandin D2 (bald people have significantly increased mast cells and PGD2 in the scalp!)

Anti-allergic effects of aged garlic extract - PubMed

To examine the effect of Aged Garlic Extract (AGE) on the function of mast cells and activated T lymphocytes, we adopted the in vitro histamine release system, the in vivo IgE mediated skin reaction system and the in vivo late phase reaction system. Consequently, at 1.25, 2.5, and 5.0% (v/v)...

pubmed.ncbi.nlm.nih.gov

Garlic has an anti-fibrotic effect by inhibiting TGF-beta (bald people have increased TGF-beta and 4x more collagen in the bald areas!)

Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1

We previously demonstrated the efficacy of garlic extract (GE) in the prevention of rat liver fibrosis by inhibiting tissue transglutaminase (tTG) act…

www.sciencedirect.com

.... and it actually works. Users report significantly better results than with standard treatments such as minoxidil or dutasteride:

https://www.hairlosstalk.com/interact/threads/rubbing-raw-crushed-garlic-on-scalp-having-quick-regro.25160/

https://www.hairlosstalk.com/interact/threads/success-very-thin-hair-regrowth-in-temple-region-now-how-can-i-thicken-it.87819/

https://www.hairlosstalk.com/interact/threads/garlic-for-hair-loss.33701/

https://www.hairlosstalk.com/interact/threads/onion-garlic-vinegar-protocol-for-hair-loss.101268/

 

[Norwood-null-by-2021]

Allicin (main active ingredient in garlic) is a SUR2 opener:

Allicin, a SUR2 opener: possible mechanism for the treatment of diabetic hypertension in rats

The garlic (Allium sativum L., Amaryllidaceae) has been popularly used in the treatment of...

www.scielo.br

(The sylfonylurea receptor 2 (SUR2) causes blood pressure lowering, while SUR1 does the opposite)
...
the expression of the sulfonylurea receptor 2B in dermal papilla cells during the production of adenosine also seems to be the mechanism of action of minoxidil:

Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil - PubMed

The mechanism by which minoxidil, an adenosine-triphosphate-sensitive potassium channel opener, induces hypertrichosis remains to be elucidated. Minoxidil has been reported to stimulate the production of vascular endothelial growth factor, a possible promoter of hair growth, in cultured dermal...

www.ncbi.nlm.nih.gov

 

[TurboFixer]

I thought all the onion and garlic stuff was worthless cope. Exciting if its actually a tool we can use.

Honestly the studies are good and all, but the threads you linked saying it worked are pretty lackluster. Basically they are always one guy without pictures who posts about garlic and gets mocked.

 

[Norwood-null-by-2021]

Unfortunately, many people make the mistake of mixing garlic with other things. That is a big problem. Because garlic works as it is. As soon as you dissolve garlic in fat, it no longer works. The pH value must not be changed either. Garlic also increases calcium intracellularly. Would you combine garlic with things that inhibit it, such as Peppermint oil, it could be ineffective as well.
You should definitely use the pure juice. Without dilution with alcohol.

 

[sonictemples]

You may wanna check this dude out

 

[Flamingflaps]

You may wanna check this dude out

Looks to have had great results. I'd try it but I'm not sure how I'd explain the stench to my girlfriend.

 

[TurboFixer]

You may wanna check this dude out

In the comments that gentleman said that Nizoral stopped his hairloss in its tracks

He probably had some sort of fungus rather than male pattern baldness right?

 

[pegasus2]

Garlic opens the potassium channels. It is EXACTLY the same principle of action as Minoxidil and even significantly better.
Then why do people take minoxidil when garlic works so much better?

Not all potassium channel openers grow hair, so that isn't the only or main MoA responsible for hair growth. Garlic does not work.

 

[Capone]

In the comments that gentleman said that Nizoral stopped his hairloss in its tracks
View attachment 150972

He probably had some sort of fungus rather than male pattern baldness right?

It definitely looks like male pattern baldness. The thinning crown and receding hairline

 

[czecha]

how does everyone say this works in the comments? i might try this sh*t out since I am a huge loner atm anyways

 

[czecha]

 

[TurboFixer]

It definitely looks like male pattern baldness. The thinning crown and receding hairline

really good point


its just strange that nizoral would be enough to stop male pattern baldness

 

[czecha]

really good point


its just strange that nizoral would be enough to stop male pattern baldness

shrooms upregulate dht as a protective response

 

[Norwood-null-by-2021]

Not all potassium channel openers grow hair, so that isn't the only or main MoA responsible for hair growth. Garlic does not work.

But. ALL! This is what the Pubmed studies say. You can check it out.

Fungi increase mast cells. These mast cells lower IGF-1 by 60%, increase DHT by 80% and also increase prostaglandin D2, since this prostaglandin is a component of mast cells.
It is also correct that ket shampoo works against Androgenetic Alopecia on its own and has already led to new growth. There are also studies on this.

 

[Catagen]

Garlic opens the potassium channels. It is EXACTLY the same principle of action as Minoxidil and even significantly better.
Then why do people take minoxidil when garlic works so much better?

Why would you want something which is not proven to work, even if minoxidil works because of potassium channel opening, why not use a more potent version of it as topical min which works in about 60% of people, what if garlic works in 1/100 people for Androgenetic Alopecia? Its like why use saw palmetto when it does the same thing but at sh*t potency and can cause same sides. The question is what is the molecule in garlic which causes this.

 

[jamesbooker1975]

Garlic opens the potassium channels. It is EXACTLY the same principle of action as Minoxidil and even significantly better.
Then why do people take minoxidil when garlic works so much better?

It is not know how exactly minoxidil work on male pattern baldness. There is not a single study that really show it, plus not all the potassium channels opens works on hair loss.