Formulae for calculating male pattern baldness inheritance - Update

chewbaca

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Its known that male pattern baldness is inherited from Mum's X gene only for male offspring.....Mum determines baldness trait for boys(XY) while both mum and dad dtermines the baldness trait for girls(XX)....FOR MALES ONLY X GENE which is basically MUM, WHEREAS FOR FEMALES BOTH MUM AND DAD IS THE FACTOR FOR male pattern baldness..let's calculate




General science is Female = XX and Male = XY (Note that for females which is XX, The 2ndX is from the father wheareas for male which is XY, there is no X gene to inherit from his own Dad,only Y which is not a factor for male pattern baldness).So here's how u were born as male or female..its the sperm of the dad which decides to give X or Y to mum, thus determing the sex of a baby.Note mum only contributes X but Dad can contribute both X or Y..but one parent can only contribute one gene to make a baby

X(mum)+X(dad sperm)= XX (baby girl)
X(mum) + Y (dad sperm) = XY (baby boy)




Now to find out if your mum has inherited from her own mum/dad the baldness trait( reember for females both parties play a part).THis is how u break down.starting from yr mum (females are XX format) , u have to find out if she has the Xb gene inherited from her own parents.eITHER FROM FAHER OR MOTHER OR BOTH

Xn=Normal gene from her EITHER parents
Xb=Baldness gene from her EITHER parents
Both combine to produce X_X_ WHICH IS YOUR MUM , A FEMALE


Both X chromosomes with normal gene represented by Xn Xn this would appear as normal female with no baldness trait. One normal and one baldness gene on the X chromosome pair represented by Xn Xb, this would appear as normal female too with a dormant baldness trait OFFSETTED. Both X chromosomes with the baldness gene represented by Xb Xb, this would appear as a woman with pattern baldness

So yr mum if she is not losing hair she is either XnXn or XnXb (normal),
if she is losing hair she is XbXb (mum with pattern baldness)
And then her husband (your own dad) comes in with his Y from his sperm and u are born

XnXn(normal mum)+Y =XnY (son without male pattern baldness inheritance)
XbXn(normal mum)+Y = XbY (son with male pattern baldness inheritance)
XbXb(bald mum)+Y = XbY (son with male pattern baldness inheritance)


The above 3 equations show that a male has to inherit the Xb gene specifically from his mother's coding to suffer from male pattern baldness, not from his father as he only contributes Y for male baby, not a factor gene for male pattern baldness as mentioned earlier for males.....So it doesnt mattter if yr mum suffers from hair loss or not...THe trait could still be there lying dormant (eg.XbXn) for : Reason is that there is another Xn there to offset the trait which is why she doesnt suffer.and in turn u as a male child has inherited her Xb gene as the dominant and u have no Xn from yr own DAD to offset it....which is why u have male pattern baldness!!...to get that Xn from your own dad, u have to born a female making it XbXn - offsetted case..THE BALDNESS TRAIT IS ONLY FOUND IN X CLASS GENE AND X CLASS IS ALSO CONTRIBUTED BY DAD FOR MAKING A GIRL(XX) SUPPORTING THE ABOVE HYPOTHESES AND ON WHY FEMALES ALSO SUFFER FROM HAIR LOSS..THEY HAVE BOTH X_X_..THIS PROVES THAT Y FROM FATHER DOESNT PLAY A PART IN male pattern baldness AS ITS NON EXISTENT IN FEMALE BABIES
Update at the bottom of the page
So this suggest that if u are male u gotta look at both yr Grandpa,grandmum and MUM to see if they are bald and passed it on to your own MUM whch in turn pass it to u...not your own father and his own parents as he only play a factor for baby girl with male pattern baldness, tat is if u have a sis, she looks at both your mum and dad and their respective grandparents while u must look at your MATERNAL BLOODLINE ONLY.....As for yr sis...your parents play a part for Baldness trait as they gave both X..if she is XbXb, she has the trait as both baldness genes are inherited from both mum and dad Update: for those havng difficulty nderstanding here is a pictorial diagram ,scroll down on the page link :
be1b.shtml
 

chewbaca

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Looking from my Grandad side; it seems that he has temple recede only....SO lost likely i will follow his pattern.....This explains why my Identical twin Brother doesnt suffer from vertex loss......his is only frontal and temple...
 

chewbaca

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Demlotcrew said:
I will comment as soon as i have time to go through it all.

andrew

i think its not so hard to understand...cause i have simplified, added and modified the whole concept but the core logic is correct...if u have any doubts or u dont want to go thr it all..if u are male..just fnd out if your maternal grandparents any of them suffer from hair loss....then look at yr mum...here is the tricky part....if her parents suffer, and she dont.....she may have the gene but its dormant.....now the Q is did u inherit her Xn or Xb gene as your primary X......now no one knows what r the chances of inheriting either gene......that's the burning Question...so good gauge will be watching your mum's brothers, your uncles...again its hard to predict...Well my take is that if they have hair loss but not totally bald, most likely u will follow their pattern too....so in a way its a give and take situation...

now i think this post is quite important to those who think they have inherited balding...and also there is no way of modifying the Xb gene u have iherited from yr mum, if u do it may have sever implications yet unknown...but again there are other genes involved which determine the severity,sge of onset, trigerring ect....which i forgot to asdd nt he first post....currently gene theraphy is geared towards dealing with these other genes
 

Trent

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its not nearly this simple. the genetic patterns of male pattern baldness have not been discovered yet, mostly because it doesn't follow a simple dominant or X-linked pattern. Most likely, the inheritance is multifactorial (involves many genes and/or chromosomes) or it is a variable penetrance (meaning even those that inherit the "gene" show variable responses and severities of it despite what their parents/grandparents have experienced). the only conclusions you can make about male pattern baldness and genetics is if you have a lot of it in your family, you are more likely to have male pattern baldness, and more likely to get a more severe form. If you have little hairloss in your family, you are less likely to get it, and less likely to get a severe form. nothing is 100 percent. take me, none of my uncles have any hairloss, my dad is just starting to bald at 53, my mom's dad died with a pretty full head at 55 but here i am at 24 and starting to thin. its a crap shoot.
 

chewbaca

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Trent said:
its not nearly this simple. the genetic patterns of male pattern baldness have not been discovered yet, mostly because it doesn't follow a simple dominant or X-linked pattern. Most likely, the inheritance is multifactorial (involves many genes and/or chromosomes) or it is a variable penetrance (meaning even those that inherit the "gene" show variable responses and severities of it despite what their parents/grandparents have experienced). the only conclusions you can make about male pattern baldness and genetics is if you have a lot of it in your family, you are more likely to have male pattern baldness, and more likely to get a more severe form. If you have little hairloss in your family, you are less likely to get it, and less likely to get a severe form. nothing is 100 percent. take me, none of my uncles have any hairloss, my dad is just starting to bald at 53, my mom's dad died with a pretty full head at 55 but here i am at 24 and starting to thin. its a crap shoot.

Anyway i cant vouch for the credibility of the formulae thing above.....Do u know if the above theories were based on scintific fact or just surface studies?...It will be sueful if anyone knows if his X and Y thingy is CONFIRMED FACT by studies....meaning its a 100% fact at this point of time.....not int he conteext of male pattern baldness but in the context of the human genome science...
 

rapidfrontal

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I am interested enough in this topic to look at your comments, but I lost interest almost right away, because I am of the opinion that male pattern baldness coming from your mother's side is complete and total bullshit. I am told by numerous doctors and others and have read all over the place that that is a misnomer. The baldness gene comes from anywhere in your family.
 

chewbaca

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rapidfrontal said:
I am interested enough in this topic to look at your comments, but I lost interest almost right away, because I am of the opinion that male pattern baldness coming from your mother's side is complete and total bullshit. I am told by numerous doctors and others and have read all over the place that that is a misnomer. The baldness gene comes from anywhere in your family.

any links to support yr claim....i am interested cause the above theory is theone i came across more often during my search.look at this link.it seems to be from a reputed website in gene research

http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109200

What the info on the link suggest that male pattern baldness is Autosomal dominant in males..the word automominal means Requires only one affected parent have the trait to pass it to offspring and is not a sex chromosome which is contributed by the father to make male babies(Y).
 

JayB

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there is no way to calculate. Come on , dont you find it funny how every website describing hair loss says "it may skip generations" and "you can be the first in your family to suffer from it"
What a joke. They have NO IDEA what genes cause it. None.
 

Zen2Bald

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I asked my derm and she said that there is no single gene that is involved in male pattern baldness and that the conditions (of genes and hormones) can be inherited from either side of the family.
 

chewbaca

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Zen2Bald said:
I asked my derm and she said that there is no single gene that is involved in male pattern baldness and that the conditions (of genes and hormones) can be inherited from either side of the family.

did u specifically ask for males?.......the above theories state that only females may have the father as a contributing factor....and that female may inheirt that trait and pass it on to her son...which actually rounds up to saying that it can be inherited from either side of the family...in this case the son has inherited the trait indirectly from his maternal grandfather.....there were studies done on the Y chromsome and it states tat there is no male pattern baldness gene in it.......
 

rapidfrontal

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Chewbaca, I have no links to support my claim and I certainly am no geneticist, but since I've started to have problems with my hair it seems more often than not I hear that the Mother's link is a misnomer.
 

Bismarck

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chewbaca,
first winner of the HairDot Medal 2005 for exceptional contributions to Alopecia research.

Congratulations !
 

Uiskii to Biiru

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chewbacca,

I hate to burst your bubble, but the link that you provided actually refutes your claim of a Mendellian inheritence pattern for male pattern baldness.

To quote:

Early baldness of the ordinary type has been thought to be autosomal dominant in males and to be autosomal recessive in females who transmit the trait if heterozygous but are bald only if homozygous (Osborn, 1916; Snyder and Yingling, 1935)

Note that it says "has been thought", then cites examples of studies done in 1916 and 1935 respectively.

Kuster and Happle (1984) reviewed the genetics of male pattern baldness and concluded that the Osborn hypothesis had not been thoroughly tested and was thus of questionable validity. In their analysis of 5 previous studies, Kuster and Happle (1984) concluded that a polygenic mode of inheritance was more likely.

The article then cites a more recent study which refutes the "Osborn" claim (i.e. the first citation in the first quote I posted... the one which supports a Mendellian inheritance pattern).

Afterwards, the article just presents a number of studies which support the idea that male pattern baldness is inherited from a combination of genes as opposed to a single gene.
 

juststarting

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Another wacky post from chewbaca :) :hairy:
lol
 
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