Special warnings about this medication
If a pregnant or breastfeeding woman is exposed to Avodart, the drug may harm the developing baby (see "Special information if you are pregnant or breastfeeding").
You should not donate blood while taking Avodart or for 6 months after stopping treatment to avoid exposing pregnant or breastfeeding women to blood that contains the drug.
.Avodart can be absorbed through the skin. Because the drug could affect a developing baby, pregnant women, women who may become pregnant, and breastfeeding women should strictly avoid skin contact with the drug.
Dutasteride is in the FDA pregnancy category X. This means that it is known to cause birth defects in an unborn baby. Women who are or who may become pregnant must not take dutasteride and must not handle dutasteride capsules. The medication can be absorbed through the skin and may cause birth defects in the unborn baby. If contact is made with leaking capsules, the contact area should be washed immediately with soap and water.
a woman who is pregnant with a male baby gets enough AVODART into her body after swallowing it or through her skin after handling it, the male baby may be born with abnormal sex organs.
Teratogenecity in Females
Dutasteride is contraindicated for use in women of childbearing age since birth defects in males can occur if significant amounts of the drug are absorbed into the body during fetal development. It is advised that the soft Gelatin Capsules not be handled by pregnant women out of concern that they may cause harm to the male fetus. However, to our knowledge, there has not been a single reported case of birth defects caused by women handling broken or crushed finasteride tablets or dutasteride soft gelatin capsules. The concern of handling crushed tablets or gelatin capsules seems to revolve around the FDA policy of assuming maximal possible absorption of the full concentration of the medication during any contact.
There is no evidence that exposure of dutasteride to pregnant women through semen is a risk to the human fetus, but for those patients who wish to limit any potential contact of dutasteride to their partner during pregnancy, a condom can be worn once conception has occurred. Your safest solution is to delay conception until you have ceased taking dutasteride for 6 months or to use a condom for 6 months after cessation of dutasteride should your significant other become pregnant.
There were dose and time dependent decreases in fertility, epididymal sperm conts, reduced weights of the epididymis, prostate, and seminal vesicles and microscopic changes in the male reproductive organs. The fertility effects were reversed by recovery week 6 at all doses and sperm counts were normal at the end of a 14-week recovery period.
There is no evidence that exposure of dutasteride to pregnant women through semen is a risk to the human fetus
Dutasteride is in the FDA pregnancy category X. This means that it is known to cause birth defects in an unborn baby.
Steady-state serum and semen concentrations are achieved at about 6 months. On average, semen concentrations are 11.5% of serum dutasteride concentrations in healthy patients at 1 year. Because of the long half-life of dutasteride, serum concentrations remain detectable (> 0.1 ng/ml) for up to 4 to 6 months after stopping therapy. Dutaseride pharmacokinetics have not been evaluated in patients under 18 years of age. The effect of race on dutasteride pharmacokinetics has not been studied.
Dutasteride is metabolized in the liver via CYP3A4 enzyme. Two minor mono-hydroxylated metabolites and 3 major metabolites have been identified. Of these metabolites, the 6beta-hydroxydutasteride is the only one to have activity comparable to that of dutasteride. Dutasteride and its metabolites are primarily excreted in feces (5% unchanged drug and 40% as metabolites). Only trace amounts of unchanged drug were found in urine (<1%). The dose unaccounted for was approximately 55%.
Deaner said:I don't see how those are contradictions? Yea, the drug is KNOWN to cause harm to the unborn baby, of course it is, DHT inhibitors do that to fetuses. BUT, it didn't say that the semen of a man on treatment is KNOWN to cause harm to the unborn baby. Big difference there.
Troymaclure said:ok...fair enough...but, why do you figure they warn that a woman who may get pregnant should avoid 'contact' with it...do you not figure that, between the lines, they mean from sperm from a man taking the drug? Because otherwise it's pretty vague, don't you think.
The bottom line being that of course a DHT / 5ar inhibitor will cause abnormalities to a developing foetus, but i think they should publish a more definitive statement on the issue of 'contact' to a woman 'who may become pregant'...so that the more simple folk like me can get it straight in our heads
They'll have to say everything to could be possible. I would stop taking a month before I make the wife pregnant (whats the english verb for that).
Some argued that topical finasteride has to be effective because Merck says woman shouldn't handle broken pills but thats like trying to commit suicide with Aspirin because sudden death is listed as a side effect...
before I make the wife pregnant (whats the english verb for that).
Troymaclure said:before I make the wife pregnant (whats the english verb for that).
The correct English verb is 'before you get her up the duff'
Bearing in mind that I myself am one of those simple folk, would I be correct in saying that the sexual development of a foetus occurs approx. 3 months after conception, thus making this the most crucial period for a mother-to-be to avoid contact with 5ar inhibitors?Troymaclure said:The bottom line being that of course a DHT / 5ar inhibitor will cause abnormalities to a developing foetus, but i think they should publish a more definitive statement on the issue of 'contact' to a woman 'who may become pregant'...so that the more simple folk like me can get it straight in our heads
Slartibartfast said:Bearing in mind that I myself am one of those simple folk, would I be correct in saying that the sexual development of a foetus occurs approx. 3 months after conception, thus making this the most crucial period for a mother-to-be to avoid contact with 5ar inhibitors?Troymaclure said:The bottom line being that of course a DHT / 5ar inhibitor will cause abnormalities to a developing foetus, but i think they should publish a more definitive statement on the issue of 'contact' to a woman 'who may become pregant'...so that the more simple folk like me can get it straight in our heads
Slarti
tynanW said:So bottom line for stupid people reading this thread:
If it safe to take Finasteride while trying to conceive ?
none of your science words here just some straight talking 'yes' or 'no's
Ty
For anyone who has been taking the standard dose that's certainly true. I was thinking more of how quickly a woman would metabolize the small volume of Dutasteride transmitted via the semen of a man on said drug.Buffboy said:Slartibartfast said:...would I be correct in saying that the sexual development of a foetus occurs approx. 3 months after conception, thus making this the most crucial period for a mother-to-be to avoid contact with 5ar inhibitors?
Slarti
Could be. But if it's in your semen while making the girl pregnant, I think your kid is in trouble. Remember Dutasteride can stay as long as 4-6 months in the body.