Exploring The Hormonal Route. Hair=life.

[DogoDiLaurentiis]

Can you please explain further.
I think by taking Ostarine I blocked the Androgen receptors in the scalp thus upregulating them.
Do you think by applying betamethasone, I can unregulated the Ostrogen receptor whitin the Follicules
I guess the application of the gel must be a life time thing, will discontinued application causes harm inside the Follicules
Thanks

I would avoid ostarine until you figure out what's wrong, if it increases growth hormone and you've got oily skin, you're probably have an excess of GH and/or igf-1.

 

[DogoDiLaurentiis]

Do you have before and after pics?

Not before but I have posted a photo post-recovery for the first time I regained my hair.

I was so distraught over how bad it was (I had to shave my head and even then it was noticeable) that I wouldn't dare take any pics, this was back in 2007 when it first happened.

I'm in the process of recovering my hair a second time, and I have met with a stubborn obstacle, namely that my igf-1 and insulin are high, I am waiting on my estrogel to get in the mail and to see one of the doctors that is going to put me on metformin, which thankfully not only increases insulin sensitivity, but actually downregulates insulin and igf-1 and lowers DHEA as well.

igf-1 actually enhances the effects of androgens, so even with it being in the upper eighth of the reference range is not good at all for my hair. It is however a testament to how androgen resistant my hair actually is, even though I am dealing with some hair loss. Because it has taken a strong increase of igf-1 to restart the hairloss process again.

Once I get that under control, get on some actual 17b estradiol, I should be in much better shape.

 

[DogoDiLaurentiis]

If my testosterone is over 1500, would 50/50 spironolactone with 3 pumps of estrogel on the scalp be enough?

Your test is quite high, I would say even if it's not clinical grade, I've had good success lowering my test with red reishi mushroom in supplement form. Even the doctor was like "how did it go down that far?" and I explained to him that I insisted on trying to get it down using supplements and red reishi works.

 

[GRme11]

All I know is that if you use progestin based steroids you basically nuke your test levels so I have no idea about CPA, I don't touch the stuff.

But with for example Trenbolone which is a progestin based steroid, if you don't take it with testosterone in tandem, your testosterone levels are likely to get nuked, so I can only presume that it will also antagonize estrogen levels. That's about the only analog I can offer you, all I can say is that I would personally prefer to have a slightly higher estrogen to progesterone balance personally for the sake of hair growth, but I think nuking progesterone to nothing is probably not a good idea either.

Thanks for responding and for your help!

 

[Swarleyd]

Is a 50 mg weekly dose of bicalutamide at least effective ?

 

[Screeech]

I'm taking it orally, via a liquid solution (the Labrasol tastes foul). Enza crosses the bbr, whereas darolutamide doesn't. Daro is the safer and more efficacious drug, but even the raw powder is prohibitively expensive. I received a quote for 600grams ( a 2.7 year supply at the recommended 600mg a day dose ) at 54000 USD.

Where on earth did you get that the recommended dosage for hair loss was 600mg a day?

IdealForehead was using 4mg a day at .2% successfully before he left the forum, and he said even that was an excessive amount.

 

[franzliszt]

Where on earth did you get that the recommended dosage for hair loss was 600mg a day?

IdealForehead was using 4mg a day at .2% successfully before he left the forum, and he said even that was an excessive amount.

Hello,
the reccomended oral dose of nubeqa (darolutamide) is 600 mg a day. This is an oral dose, not a topical one.

 

[WindR]

Not before but I have posted a photo post-recovery for the first time I regained my hair.

I was so distraught over how bad it was (I had to shave my head and even then it was noticeable) that I wouldn't dare take any pics, this was back in 2007 when it first happened.

I'm in the process of recovering my hair a second time, and I have met with a stubborn obstacle, namely that my igf-1 and insulin are high, I am waiting on my estrogel to get in the mail and to see one of the doctors that is going to put me on metformin, which thankfully not only increases insulin sensitivity, but actually downregulates insulin and igf-1 and lowers DHEA as well.

igf-1 actually enhances the effects of androgens, so even with it being in the upper eighth of the reference range is not good at all for my hair. It is however a testament to how androgen resistant my hair actually is, even though I am dealing with some hair loss. Because it has taken a strong increase of igf-1 to restart the hairloss process again.

Once I get that under control, get on some actual 17b estradiol, I should be in much better shape.

For those over 44 years, metformin might be ineffective.
pubmed.ncbi.nlm.nih.gov/19878986
ncbi.nlm.nih.gov/pubmed/28770322
www.ncbi.nlm.nih.gov/pubmed/31794067

 

[Norwoody]

Hello everyone, I am 23 years old and I have been losing my hair since I was 18 years old. Unfortunately, I have the worst baldness possible: DUPA. To sum up, I am losing my hair all over my skull which makes hair transplant impossible.
I tried finasteride, dutasteride, RU, but nothing works on this baldness because it is not linked by DHT. I am currently in depression and I don't know what to do.


What else can I try?

The big things you can try are oral minoxidil, estrogen, needling

 

[Obsessive]

Hello everyone, I am 23 years old and I have been losing my hair since I was 18 years old. Unfortunately, I have the worst baldness possible: DUPA. To sum up, I am losing my hair all over my skull which makes hair transplant impossible.
I tried finasteride, dutasteride, RU, but nothing works on this baldness because it is not linked by DHT. I am currently in depression and I don't know what to do.


What else can I try?

Those three drugs you mentioned all failed me as well (RU actually worsened my situ). @Norwoody mentioned the ONLY things that have been efficacious for me: oral min and estradiol. I'm on the fence about whether needling has every helped me but others swear by it.

 

[deathdiss]

Those three drugs you mentioned all failed me as well (RU actually worsened my situ). @Norwoody mentioned the ONLY things that have been efficacious for me: oral min and estradiol. I'm on the fence about whether needling has every helped me but others swear by it.

needling is the king

i didnt start growing in raw grass fed patches in scalp until i combined bi-estro, ketoconazole cream with derm pen microneedling at 2.5mm

 

[Norwoody]

raw grass fed lol

 

[DarkHairHair]

Those three drugs you mentioned all failed me as well (RU actually worsened my situ). @Norwoody mentioned the ONLY things that have been efficacious for me: oral min and estradiol. I'm on the fence about whether needling has every helped me but others swear by it.

You have DUPA like me ?
The oral minoxidil is not dangerous? what's the frequency of use of the oral minoxidil? I've also heard that it causes aging of the skin.

What exactly is Estradiol, a cream? I'm interested but I don't want to turn into a girl. If I can get my hair back by increasing the estro rate without turning into a girl it would be perfect.

 

[deathdiss]

You have DUPA like me ?
The oral minoxidil is not dangerous? what's the frequency of use of the oral minoxidil? I've also heard that it causes aging of the skin.

What exactly is Estradiol, a cream? I'm interested but I don't want to turn into a girl. If I can get my hair back by increasing the estro rate without turning into a girl it would be perfect.

he might be referring to bi-estro cream which is nothing...dosages are far lower unlike like the pharmacy grade estriol which will turn u into a tranny.

plus ur body needs a healthy amount of estriol/estrial anyway


we're only concerned about getting estriol/estrial on the scalp at low dosages. Not in the system.

 

[ReturnOfExtreme]

Is a 50 mg weekly dose of bicalutamide at least effective ?

no

 

[ReturnOfExtreme]

Is transitioning to be MTF worth it for the hair?

I mean, it’s not transitioning if you don’t pass, in which most people here would stay looking male regardless due to clothing style, hair cuts, facial hair, etc. They would end up looking a lot younger though

 

[Almas]

I would like to use Bicalutamide 50mg + dutasteride / finasteride. Does bicalutamide affect the heart? I have read studies that say it causes heart failure. I will just remove gynecomastia with surgery

 

[Norwoody]

What cracks me up is people who say I want regrowth without any kind of side effects whatsoever. Let's be honest, for any of us on here who have experienced significant regrowth, you're definitely going to have to go through at least some sort of side effects. Now, those side effects need not be permanent; as you can try going on a more aggressive treatment protocol for a temporary period of time, and then go into a more conservative maintenance regimen. Along with that, it's a matter of choice between which side effects you are willing to go through. If you aren't willing to go through very much sexual side effects, then you'll have to take smaller doses of hormonally based substances. But then you'll most likely have to risk some side effects on the skin with oral minoxidil for a while. Or, you might prefer the other way around. In any case, it's give-and-take and there's some unrealistic people all over these forums who are basically asking for a cure that has zero side effects.

 

[NickGardner0651]

What cracks me up is people who say I want regrowth without any kind of side effects whatsoever. Let's be honest, for any of us on here who have experienced significant regrowth, you're definitely going to have to go through at least some sort of side effects. Now, those side effects need not be permanent; as you can try going on a more aggressive treatment protocol for a temporary period of time, and then go into a more conservative maintenance regimen. Along with that, it's a matter of choice between which side effects you are willing to go through. If you aren't willing to go through very much sexual side effects, then you'll have to take smaller doses of hormonally based substances. But then you'll most likely have to risk some side effects on the skin with oral minoxidil for a while. Or, you might prefer the other way around. In any case, it's give-and-take and there's some unrealistic people all over these forums who are basically asking for a cure that has zero side effects.

^ Couldnt have said it any better. Also, everyone's body reacts differently to different hormones and treatments depending on what is actually causing the loss in the first place. In the majority of cases (99%) it is androgens. Taking aggressive regimens with high doses of AA and Estrogens has worked ie: lots of insane results in this thread. The best thing to do IMO is start low dosage wise and slowly taper up until you reach a level of side effects you are not comfortable with and find the "sweet spot" (it will be different for everyone). Lastly, growing hair takes time and most people are unwilling to stay on a regimen if they are not seeing immediate results. Pick a structured regimen and stick with it for at least 9-12 months and than re-asses if it is working or not.

 

[Almas]

^ Couldnt have said it any better. Also, everyone's body reacts differently to different hormones and treatments depending on what is actually causing the loss in the first place. In the majority of cases (99%) it is androgens. Taking aggressive regimens with high doses of AA and Estrogens has worked ie: lots of insane results in this thread. The best thing to do IMO is start low dosage wise and slowly taper up until you reach a level of side effects you are not comfortable with and find the "sweet spot" (it will be different for everyone). Lastly, growing hair takes time and most people are unwilling to stay on a regimen if they are not seeing immediate results. Pick a structured regimen and stick with it for at least 9-12 months and than re-asses if it is working or not.

Perhaps Bicalutamide 50mg + finasteride is the golden mean? I am thinking about removing the gyno with an operation
Finasteride and dutasteride sooner or later stop helping everyone. So we all need a fallback. I began to go bald at the age of 16, with aggressive baldness, dutasteride and finasteride are powerless