Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Only orally, there is no reason for topical use.
It needs to pass the liver to prosper lol
Thanks. What do you think about its safety/side effect profile?
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I really dislike spironolactone because of its effect on many things like the electrolyte imbalance effect and many more, just no. Especially of the fact that you need to increase dosage after time to make it "still work"... Thats really a pain in the *** for people trying to fight hair loss for life. You can't take huge amounts of a SAA, like spironolactone, just no, don't do it if you appreciate your health.
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Orally only. It needs to be synthesized in your digestive system. All the spironolactone creams out there are snake oil.
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Thats why I would choose Bicalutamide. Tho I would consider taking Eplerenone or any other MCR agonist with Bicalutamide as it seems that the regrowth on spironolactone is superior to Bica, reason may be to the MCR properties spironolactone has. And Eplerenone has the MCR properties, but no AA properties.
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I am not aware of increase dosage for spironolactone under hrt. The dosages I have seen range from 100-200
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Yes, thats the dose you need, especially for hair, however, users on this forum proved all the time again that they needed to increase their dosage.
Probably because of the steroidal pathway. It's hard to regulate long term use on ANY steroid
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The only AA that has demonstrated resistance in Daro
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And it's used for resistant PC... haha, what a joke
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Cure my arse. You will still lose the rest of your follicles with the extent of your targeted norwood assigned to you at birth.
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Probably, CB-03-01 is from the same class, no wonder it works soo poorly, and it's effects decrease just about 6 months. Pure BS lol
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What's so funny about it? Do you think AA where invented for you to carry a hairstyle?
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I am doomed to be NW7 with severe donor thinning. I still have a NW2, but diffuse NW7.
And I am 17.
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the affinity of bicalutamide for the AR is relatively low as it is approximately 30 to 100 times lower than that of DHT, which is 2.5- to 10-fold as potent as an AR agonist as testosterone (https://en.wikipedia.org/wiki/Bicalutamide )
So even if dutasteride block the production of DHT from T, and even if bicalutamide is sitting on the androgen receptors, the frontdoor DHT and the backdoor DHT can easily kick out the bicalutamide, and then simulate the androgen receptor 2 to 10 times more than T.
So even if dutasteride block the production of DHT from T, and even if bicalutamide is sitting on the androgen receptors, the frontdoor DHT and the backdoor DHT can easily kick out the bicalutamide, and then simulate the androgen receptor 2 to 10 times more than T.
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No, but the fact it was invented for resistant PC is just ridiculous imo.
Well there's AntyDHTor who went Norwood negative infinity xD
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Like I said. We are talking about 4% cases who will still experience hair loss after chemical or physical castration. Some folks are luckier than others. 96% of them.