science-jay
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Ok here's my personal story
I'm 32
started to see hairloss at age 21
started treatment at age 24 (Norwood 1,5 - 2)
started with Nizoral shampoo (use the stuff now for 8 years)
added minoxidil (now used for 6 years)
added topical spironolactone-cream (now used for 4 years)
added Propecia (now used for 3 years, but will stop soon)
added Folligen (now used for 3 years)
other internals: l-cystine, saw palmetto, green tea, l-arginine, nettle, fish oil, black current oil etc (for over 2 years)
during this time degradation of hair to Norwood 3
I guess i'm a bad responder to propecia, my brother is 3 years older and has less hairloss than me (without using any treatments)
After reading a lot of scientific articles,
i've come to my last resort...the disputed and often scam-artist realted 'hairloss-ejaculation theory'
I stopped ejaculation since 4 weeks (damn i'm horny
I still practice sex with my Girlfriend but learned to halt ejaculation.
i love sex, and i'm not willing to give it up for hairloss for sure! But my curious mind and discipline is even stronger and i'm willing to test this theory for 5 months. If there's a relation, wich i believe there is (I already have absolute no ichiness anymore on the scalp and see less hairs in the shower) i try to find a balance between ejacultion and hairloss.
Read the articles below if your seriously interested in the subject,
i was very sketical at first and believed it was total BS, but after some reading i DO see some correlations
ejaculation increases prolactine and DHT levels secreted by the pituitary gland, wich is bad for you hair...
: Psychoneuroendocrinology. 2001 Apr;26(3):287-94. Links Coitus-induced orgasm stimulates prolactin secretion in healthy subjects.Exton MS, Kruger TH, Koch M, Paulson E, Knapp W, Hartmann U, Schedlowski M. Institute of Medical Psychology, University of Essen, Hufelandstrasse 55, 45122, Essen, Germany. michael.exton@uni-essen.de
Previous data have indicated that orgasm produces marked alterations in plasma prolactin concentrations in men and women. Thus, the current study aimed to extend these data by examining prolactin response to coitus in healthy males and females. Ten pairs of healthy heterosexual couples participated in the study. Blood was drawn continuously for 20 min before, during, and until 60 min following sexual intercourse and orgasm. Plasma was subsequently analysed for prolactin concentrations. Coitus-induced orgasm produced a marked elevation of plasma prolactin in both males and females. Plasma prolactin concentrations remained elevated 1 h following orgasm. These data, together with previous evidence that masturbation-induced orgasm produces pronounced, long-lasting increases in plasma prolactin concentrations in both males and females, suggest a role for acute prolactin alterations in modifying human sexual desire following orgasm.
1: Am J Pathol. 2006 Mar;168(3):748-56. Links Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression.Foitzik K, Krause K, Conrad F, Nakamura M, Funk W, Paus R. Department of Dermatology, University Hospital Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany. kfoitzik@yahoo.com
The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects in mammals and is also found in extrapituitary sites, including murine skin. Here, we show by reverse transcriptase-polymerase chain reaction and immunohistology that, contrary to a previous report, human skin and normal human scalp hair follicles (HFs), in particular, express both PRL and PRL receptors (PRL-R) at the mRNA and protein level. PRL and PRL-R immunoreactivity can be detected in the epithelium of human anagen VI HFs, while the HF mesenchyme is negative. During the HF transformation from growth (anagen) to apoptosis-driven regression (catagen), PRL and PRL-R immunoreactivity appear up-regulated. Treatment of organ-cultured human scalp HFs with high-dose PRL (400 ng/ml) results in a significant inhibition of hair shaft elongation and premature catagen development, along with reduced proliferation and increased apoptosis of hair bulb keratinocytes (Ki-67/terminal dUTP nick-end labeling immunohistomorphometry). This shows that PRL receptors, expressed in HFs, are functional and that human skin and human scalp HFs are both direct targets and sources of PRL. Our data suggest that PRL acts as an autocrine hair growth modulator with catagen-promoting functions and that the hair growth-inhibitory effects of PRL demonstrated here may underlie the as yet ill-understood hair loss in patients with hyper-prolactinemia.
Hum Reprod Update. 2006 Jul-Aug;12(4):437-48.
Oxytocin--its role in male reproduction and new potential therapeutic uses.
Clinical Science at South Bristol (Obstetrics & Gynaecology), Henry Wellcome Laboratories for Integrated Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol, UK.
Oxytocin (OT) is traditionally thought of as a "female" neurohypophysis hormone due to its role in parturition and milk ejection. However, OT is recognized as having endocrine and paracrine roles in male reproduction. At ejaculation, a burst of OT is released from the neurohypophysis into the systemic circulation and stimulates contractions of the reproductive tract aiding sperm release. There is conclusive evidence that OT is synthesized within the mammalian testis, epididymis and prostate and the presence of OT receptors (OTRs) through the reproductive tract supports a local action for this peptide. OT has a paracrine role in stimulating contractility of the seminiferous tubules, epididymis and the prostate gland. Interestingly, OT has also been shown to modulate androgen levels in these tissues via stimulation of the conversion of testosterone to dihydrotestostone (DHT) by 5alpha-reductase.
The elucidation of OT's role in male reproduction has suggested a number of potential therapeutic uses for this hormone. Exogenous administration of OT has, in some cases, been shown to increase the numbers of ejaculated sperm, possibly by stimulating contractions of the reproductive tract and thus aiding sperm passage. Within the prostate, OT has been shown to affect gland growth both directly and via its interaction with androgen metabolism. Prostate pathologies due to unregulated cell proliferation/growth, such as benign prostatic hyperplasia and cancer, are unfortunately very common and few effective treatments are available. Greater understanding of paracrine growth mediators, such as OT, is likely to provide new mechanisms for treating such
I'm 32
started to see hairloss at age 21
started treatment at age 24 (Norwood 1,5 - 2)
started with Nizoral shampoo (use the stuff now for 8 years)
added minoxidil (now used for 6 years)
added topical spironolactone-cream (now used for 4 years)
added Propecia (now used for 3 years, but will stop soon)
added Folligen (now used for 3 years)
other internals: l-cystine, saw palmetto, green tea, l-arginine, nettle, fish oil, black current oil etc (for over 2 years)
during this time degradation of hair to Norwood 3
I guess i'm a bad responder to propecia, my brother is 3 years older and has less hairloss than me (without using any treatments)
After reading a lot of scientific articles,
i've come to my last resort...the disputed and often scam-artist realted 'hairloss-ejaculation theory'
I stopped ejaculation since 4 weeks (damn i'm horny
I still practice sex with my Girlfriend but learned to halt ejaculation.
i love sex, and i'm not willing to give it up for hairloss for sure! But my curious mind and discipline is even stronger and i'm willing to test this theory for 5 months. If there's a relation, wich i believe there is (I already have absolute no ichiness anymore on the scalp and see less hairs in the shower) i try to find a balance between ejacultion and hairloss.
Read the articles below if your seriously interested in the subject,
i was very sketical at first and believed it was total BS, but after some reading i DO see some correlations
ejaculation increases prolactine and DHT levels secreted by the pituitary gland, wich is bad for you hair...
: Psychoneuroendocrinology. 2001 Apr;26(3):287-94. Links Coitus-induced orgasm stimulates prolactin secretion in healthy subjects.Exton MS, Kruger TH, Koch M, Paulson E, Knapp W, Hartmann U, Schedlowski M. Institute of Medical Psychology, University of Essen, Hufelandstrasse 55, 45122, Essen, Germany. michael.exton@uni-essen.de
Previous data have indicated that orgasm produces marked alterations in plasma prolactin concentrations in men and women. Thus, the current study aimed to extend these data by examining prolactin response to coitus in healthy males and females. Ten pairs of healthy heterosexual couples participated in the study. Blood was drawn continuously for 20 min before, during, and until 60 min following sexual intercourse and orgasm. Plasma was subsequently analysed for prolactin concentrations. Coitus-induced orgasm produced a marked elevation of plasma prolactin in both males and females. Plasma prolactin concentrations remained elevated 1 h following orgasm. These data, together with previous evidence that masturbation-induced orgasm produces pronounced, long-lasting increases in plasma prolactin concentrations in both males and females, suggest a role for acute prolactin alterations in modifying human sexual desire following orgasm.
1: Am J Pathol. 2006 Mar;168(3):748-56. Links Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression.Foitzik K, Krause K, Conrad F, Nakamura M, Funk W, Paus R. Department of Dermatology, University Hospital Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany. kfoitzik@yahoo.com
The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects in mammals and is also found in extrapituitary sites, including murine skin. Here, we show by reverse transcriptase-polymerase chain reaction and immunohistology that, contrary to a previous report, human skin and normal human scalp hair follicles (HFs), in particular, express both PRL and PRL receptors (PRL-R) at the mRNA and protein level. PRL and PRL-R immunoreactivity can be detected in the epithelium of human anagen VI HFs, while the HF mesenchyme is negative. During the HF transformation from growth (anagen) to apoptosis-driven regression (catagen), PRL and PRL-R immunoreactivity appear up-regulated. Treatment of organ-cultured human scalp HFs with high-dose PRL (400 ng/ml) results in a significant inhibition of hair shaft elongation and premature catagen development, along with reduced proliferation and increased apoptosis of hair bulb keratinocytes (Ki-67/terminal dUTP nick-end labeling immunohistomorphometry). This shows that PRL receptors, expressed in HFs, are functional and that human skin and human scalp HFs are both direct targets and sources of PRL. Our data suggest that PRL acts as an autocrine hair growth modulator with catagen-promoting functions and that the hair growth-inhibitory effects of PRL demonstrated here may underlie the as yet ill-understood hair loss in patients with hyper-prolactinemia.
Hum Reprod Update. 2006 Jul-Aug;12(4):437-48.
Oxytocin--its role in male reproduction and new potential therapeutic uses.
Clinical Science at South Bristol (Obstetrics & Gynaecology), Henry Wellcome Laboratories for Integrated Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol, UK.
Oxytocin (OT) is traditionally thought of as a "female" neurohypophysis hormone due to its role in parturition and milk ejection. However, OT is recognized as having endocrine and paracrine roles in male reproduction. At ejaculation, a burst of OT is released from the neurohypophysis into the systemic circulation and stimulates contractions of the reproductive tract aiding sperm release. There is conclusive evidence that OT is synthesized within the mammalian testis, epididymis and prostate and the presence of OT receptors (OTRs) through the reproductive tract supports a local action for this peptide. OT has a paracrine role in stimulating contractility of the seminiferous tubules, epididymis and the prostate gland. Interestingly, OT has also been shown to modulate androgen levels in these tissues via stimulation of the conversion of testosterone to dihydrotestostone (DHT) by 5alpha-reductase.
The elucidation of OT's role in male reproduction has suggested a number of potential therapeutic uses for this hormone. Exogenous administration of OT has, in some cases, been shown to increase the numbers of ejaculated sperm, possibly by stimulating contractions of the reproductive tract and thus aiding sperm passage. Within the prostate, OT has been shown to affect gland growth both directly and via its interaction with androgen metabolism. Prostate pathologies due to unregulated cell proliferation/growth, such as benign prostatic hyperplasia and cancer, are unfortunately very common and few effective treatments are available. Greater understanding of paracrine growth mediators, such as OT, is likely to provide new mechanisms for treating such