Cyclosporine A - Possible Cure For Hair Loss

JLC

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Just looking at the news headlines on BBC as I do each morning and saw this article:

http://www.bbc.co.uk/news/health-44038756

Potential new cure found for baldness

A potential new cure for baldness has been discovered using a drug originally intended to treat osteoporosis.

Enhanced hair growth is a side-effect of a different drug, cyclosporine A, used to treat autoimmune diseases.

And researchers found it also inhibited a protein, SFRP1, that blocks a molecular pathway, WNT, vital for the growth of many tissues, including hair.

The new cure uses another drug, Way-316606, that was designed to inhibit SFRP1 as treatment for osteoporosis.

Project leader Dr Nathan Hawkshaw, from the University of Manchester, said it could "make a real difference to people who suffer from hair loss".

Only two drugs are currently available to treat balding (androgenetic alopecia):

  • minoxidil, for men and women
  • finasteride, for men only
Neither is available on the NHS and both have side-effects and are not always very effective, so patients often resort to hair transplantation surgery instead.

The research, published in PLOS Biology, was done in a lab, with samples containing scalp hair follicles from more than 40 male hair-transplant patients.

And Dr Hawkshaw told the BBC a clinical trial would be needed to see if the treatment was effective and safe in people.

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What causes hair loss?
Hair loss is a daily occurrence and generally nothing to worry about. Some types are temporary and some are permanent.

You should see a doctor because of:

  • sudden hair loss
  • developing bald patches
  • losing hair in clumps
  • head itching and burning
  • worry about hair loss
Source: NHS Choices

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A British Association of Dermatologists spokesman told the BBC: "This is a very interesting study.

"As the researchers say, hair loss is a common disorder and it can cause considerable damage to emotional health, including loss of self-esteem and confidence.

"That said, more research will need to be done before it can be used by people with hair loss.

"For individuals with hair loss, treatments can be very hit and miss. There isn't one which is universally effective.

"For that reason new treatments are exciting as they give people more treatment options that may be effective."
 

JLC

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mods delete thread, can't change thread title where I put the wrong drug name.
 

MorningGlory

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Just saw this and came on here to post it. To have another clinically approved treatment at our disposal would be excellent.
 

Dayday

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The drug name is way-316606. Cyclosporine A is the drug from the 1980's that comes with side effects. U can purchase way-316606 offline. Its $215 dollars for 10mg!!
 

MorningGlory

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Fk this sh*t man lots of dicovers and no one single treatment im really tired of this i just wanna wake up one day and find a release date fk it man im really fed up

Manage your expectations. I don’t think a panacea is coming any time soon. But we may have a larger tool box to work from.
 

Dayday

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It also says that if it was to work that it could be applied in gel or via a shampoo.
 

reuters

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This to me sounds a lot more trustworthy than the Italian lotion, I am very hopeful and can't wait for more information .
 

opti

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Here is the study :

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003705#pbio.2003705

"A stock solution of WAY-316606 was made at a 10 mM concentration by adding 2,229.8 μL of DMSO (Sigma) to 10 mg of WAY-316606"
-> soluble in DMSO

"[...]demonstrates that WAY-316606 is a promising new pharmacological promoter of human hair growth, whose toxicity profile [26] is expected to be more favourable than that of CsA."

take a look at the pictures and hairs after 6 days treatment, since it also increases keratin expression. These hair look so thick on the treated HF.

But well all those clinical trials ...could take forever
 

arnoldd

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it's interesting like this drug cause hair regrowth since i read that it raises dht from studies on pubmed
 

Dayday

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It wont be long before someone gives it a try with a dermaroller seeing as it can be easily purchased offline.
 

Ollie

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Any drug that involves WNT signalling sounds like it shouldn't be guinea pigged as it has a tight association with cancer im pretty sure...
 

itchymadscalp

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I tried for almost 2 months ... no help for the itchy scalp :'( (it was cyclosporine from Lyphar - 150 to 500mg)

I tried orally and topically (with dmso)
 
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