Complete reversal of Androgenetic Alopecia hair-loss: Case study

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RStGeorge

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Androgenetic alopecia (Androgenetic Alopecia) is a nonscarring pattern hair loss affecting both sexes. There have been no previous reports on significant response to medical treatment. Here, we present a sex reassignment patient on estrogen therapy who experienced full hair regrowth over completely alopecic scalp.

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Hair regrowth in a male patient with extensive androgenetic alopecia on estrogen therapy - PubMed

Hair regrowth in a male patient with extensive androgenetic alopecia on estrogen therapy
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Solxama

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RStGeorge said:
Androgenetic alopecia (Androgenetic Alopecia) is a nonscarring pattern hair loss affecting both sexes. There have been no previous reports on significant response to medical treatment. Here, we present a sex reassignment patient on estrogen therapy who experienced full hair regrowth over completely alopecic scalp.

pubmed.ncbi.nlm.nih.gov

Hair regrowth in a male patient with extensive androgenetic alopecia on estrogen therapy - PubMed

Hair regrowth in a male patient with extensive androgenetic alopecia on estrogen therapy
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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Impressive results. Just goes to show the only currently available cure to Androgenic Alopecia that fully works is HRT. If it can restore that kind of balding, it can restore anything.
 
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That occurred over some amount of time and she/he at the time was on numerous things. ABSOLUTELY, estrogen helped but so did the other things.


Table I. Summary of in-office visits with accompanying findings and images
Date of visit Current treatment Hair growth noted Associated photograph
August 22, 1988 Estradiol 0.05 mg, Coumadin, Zantac,
minoxidil 3%
New patient, ‘‘severe’’ male pattern baldness None
January 4, 1989 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 3%
Fine terminal hair regrowth over
vertex

Fig 1, A
August 6, 1990 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 2%, Aldactone
25 mg
Improved regrowth on vertex Fig 1, B
November 9, 1990 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 2%, Aldactone
100 mg
Marked increase in scalp hair
regrowth
Fig 1, C


April 11, 1991 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 2%, Aldactone
200 mg
Continued increase in scalp regrowth
with hair filling in


Fig 1, D
October 14, 1991 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 2%, Aldactone
200 mg, tretinoin 0.025%
Almost full regrowth of scalp with 2 in
vertex hair length and vertex
thinning (vertex and parietal scalp
regrowth [frontal regrowth)
 
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RStGeorge

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Can anyone point to any other case study where a confirmed sufferer of androgenetic alopecia with at least an NW5 pattern of loss has recovered most or all of their hair?
 
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RStGeorge

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OtyMac said:
That occurred over some amount of time and she/he at the time was on numerous things. ABSOLUTELY, estrogen helped but so did the other things.


Table I. Summary of in-office visits with accompanying findings and images
Date of visit Current treatment Hair growth noted Associated photograph
August 22, 1988 Estradiol 0.05 mg, Coumadin, Zantac,
minoxidil 3%
New patient, ‘‘severe’’ male pattern baldness None
January 4, 1989 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 3%
Fine terminal hair regrowth over
vertex

Fig 1, A
August 6, 1990 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 2%, Aldactone
25 mg
Improved regrowth on vertex Fig 1, B
November 9, 1990 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 2%, Aldactone
100 mg
Marked increase in scalp hair
regrowth
Fig 1, C


April 11, 1991 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 2%, Aldactone
200 mg
Continued increase in scalp regrowth
with hair filling in


Fig 1, D
October 14, 1991 Estradiol 0.2 mg, estrone solution,
Coumadin, minoxidil 2%, Aldactone
200 mg, tretinoin 0.025%
Almost full regrowth of scalp with 2 in
vertex hair length and vertex
thinning (vertex and parietal scalp
regrowth [frontal regrowth)
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Is it really 0.02mg of estradiol, or do you think that is an error in publication?

MtF’s take anywhere from 4mg per day upwards, right?
 
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RStGeorge

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OtyMac said:
Dr. Proctor's website has one outstanding responder with Proxiphen. If the guy continued using it, I would think probably most if not all came back.

Click to expand...

This is not what I was asking for.

This post just reads like an advertorial for a product that contains nothing more than most or other hairloss serums.

I am asking for a credible, published case study done by a neutral researcher.

Preferably one that is published in pubmed
 
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Solxama

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RStGeorge said:
Is it really 0.02mg of estradiol, or do you think that is an error in publication?

MtF’s take anywhere from 4mg per day upwards, right?
Click to expand...
I think that might be a typo. The lowest dose trans feminine people take is 2mg.
 
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OtyMac

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RStGeorge said:
This is not what I was asking for.

This post just reads like an advertorial for a product that contains nothing more than most or other hairloss serums.

I am asking for a credible, published case study done by a neutral researcher.

Preferably one that is published in pubmed
Click to expand...

I think Dr. Proctor is on the level that is why I posted that showing it is possible.

There are some quite dramatic microneedling and minoxidil studies and even the one posted about melatonin was impressive. Keep in mind a baby can take up to 18 months to develop their hair and they are in the best shape of their life. Most studies go maybe 6 months at that and the pictures of those who did improve probably should get better with time.

 
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Jakejr

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Now, you’re talking. This patient was totally bald.. And now completely reversed. I’m going to study this further.
Some of drugs are topicals. The trick is to keep gyno in check. This patient we don’t know. But none the less this line of treatment… this general idea is what needs to be elucidated… Not from a tranny or transgender, but from a regular male who wants to remain male
 
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Jakejr

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Coumadin is a blood thinner. Zantac is anti acid. So we can rule them out…Aldactone went from 25 to 200mg
 
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OtyMac

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Jakejr said:
Coumadin is a blood thinner. Zantac is anti acid. So we can rule them out…Aldactone went from 25 to 200mg
Click to expand...

I tried to find the study about oral spironolactone again but couldn't find it.

There was a 80 year old man who took spironolactone for 6 years and like the last 6 months only he was growing his hair back.

I remember the study and pictures pretty well and he was like a NW6ish and had developed hair growth all over his scalp maybe a NW5 or 4?

A couple thoughts come to me:

1) is spironolactone was totally acting DIRECTLY on the hair follicle then regrowth would have happened much sooner than 6 years.

2) if spironolactone was acting on gut microbes it would be much slower. There are studies of infants with certainly bacteria that develop PCOS later in life.
It could take some time to get the gut microbiome population back healthy again. There are an estimated 1x10^13th power number of gut microbes and overnight fixes without extraordinary measures are likely impossible.
 
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keepcoolmybabies

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none of this is anything unknown at this point. The impressive part to me is that the patient was using tretinoin back in 1991, when no one really had a clue it increased minoxidil efficacy (and particularly how) until the last decade or less. Curious though if patient was using on scalp or just face for acne/antiaging.
 
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persistentone

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keepcoolmybabies said:
none of this is anything unknown at this point. The impressive part to me is that the patient was using tretinoin back in 1991, when no one really had a clue it increased minoxidil efficacy (and particularly how) until the last decade or less. Curious though if patient was using on scalp or just face for acne/antiaging.
Click to expand...

I have not seen many studies giving estradiol to men and evaluating effects on hair loss over the course of years. You read the occasional N=1 report about a male-to-female transitioning, but I have not seen reports where men who are not transitioning are given low doses of topical estrogens in shampoo. Have you seen any studies like that? Do you have links to any of those? It would be even more interesting if they gave different estrogens (i.e., E1, E2, and E3) to different study groups. Some of those would not produce any risk of secondary sex characteristics in men, but they also might not have any effect on hair follicles. All of that should be getting teased out in studies.

What is the recommended tretinoin dose to amplify minoxidil effects and can the tretinoin be applied in a shampoo? Who makes that?
 
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keepcoolmybabies

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persistentone said:
I have not seen many studies giving estradiol to men and evaluating effects on hair loss over the course of years. You read the occasional N=1 report about a male-to-female transitioning, but I have not seen reports where men who are not transitioning are given low doses of topical estrogens in shampoo. Have you seen any studies like that? Do you have links to any of those? It would be even more interesting if they gave different estrogens (i.e., E1, E2, and E3) to different study groups. Some of those would not produce any risk of secondary sex characteristics in men, but they also might not have any effect on hair follicles. All of that should be getting teased out in studies.

What is the recommended tretinoin dose to amplify minoxidil effects and can the tretinoin be applied in a shampoo? Who makes that?
Click to expand...
I'm not sure about a tretinoin shampoo. Why not just use the topical cream? Most likely highest concentration would yield highest sulfatransferase results. But to mitigate any inflammation you can start with .025%
 
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