Cassiopea Announces Very Positive Phase 2 Twelve Months Results For Breezula

hypetraintime

New Member
My Regimen
http://www.cassiopea.com/news-and-media/press-releases/yr-2019/190416.aspx

It's happening.

12 Month Efficacy Results
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Compared to the 6 Month Efficacy Results

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hypetraintime

New Member
My Regimen
Are they in phase 3 already?

"Diana Harbort, CEO of Cassiopea, said: “We are very pleased by these excellent results which show that our topical anti-androgen is efficacious in the treatment of Androgenetic Alopecia with side effects similar to placebo and importantly without any systemic side effects. Based on these results, we plan to meet with the FDA mid-year to discuss the planned six-month Phase III trials in men. Hopefully, we will begin our Phase III program in 4Q 2019."

It's interesting that they are only planning a 6 month phase 3. They must be confident it works.
 

inmyhead

Experienced Member
"Diana Harbort, CEO of Cassiopea, said: “We are very pleased by these excellent results which show that our topical anti-androgen is efficacious in the treatment of Androgenetic Alopecia with side effects similar to placebo and importantly without any systemic side effects. Based on these results, we plan to meet with the FDA mid-year to discuss the planned six-month Phase III trials in men. Hopefully, we will begin our Phase III program in 4Q 2019."

It's interesting that they are only planning a 6 month phase 3. They must be confident it works.
So probably 2021 release date at the best, 2022 most likely.
 

Iah11

Established Member
My Regimen
surely this data disproves everyone saying winlevi will be useless for hair loss? the dose response curve does not seem very steep. the 2.5% BD group outperformed 5% BD and 7.5% QD.
 

Iah11

Established Member
My Regimen
"Diana Harbort, CEO of Cassiopea, said: “We are very pleased by these excellent results which show that our topical anti-androgen is efficacious in the treatment of Androgenetic Alopecia with side effects similar to placebo and importantly without any systemic side effects. Based on these results, we plan to meet with the FDA mid-year to discuss the planned six-month Phase III trials in men. Hopefully, we will begin our Phase III program in 4Q 2019."

It's interesting that they are only planning a 6 month phase 3. They must be confident it works.

if you compare 12 month efficacy data to the 6 month efficacy data, it seems that results are better at 6 months. Does this mean that tolerance develops to this medication like minoxidil? hard to say yet, but something to keep in mind.

EDIT: anecdotal evidence from some online experimenters is that it has worked for them for numerous years, but we won't know for real until/if it is released
 

Ryko

Member
Finally, here's for hoping it will be available in 2022. Guess, gonna have to stretch finasteride for 3 years.
 

petersonKj

Banned
My Regimen
So how does it compare to finasteride?


it's only half as good as finasteirde and probably even worse since it seems to have reached maximum efficiency after 6 months and then went downhill very quickly.

both metrics are extremely bad, hair count is a joke, an actual joke and self assessment is unlike with finasteride even worse after 6 month vs 12. the placebo group barely lost any hair so this makes the results even worse

bottom line, we are fucked no, nothing can safe us
 

Iah11

Established Member
My Regimen
Just to add to my previous post, the 5% group actually kept on improving until the 12 month mark, unlike the others. Also, the groups outside of the 7.5% BD didn't change TAHC significantly from 6 to 12 months. That is odd to me. Interpreting these results, i have some questions:

1) Did patients adhere strictly to protocol (Impossible to know). I have been part of a clinical trial for a topical. I know how easy it is to skip applications by accident. The variable, seemingly random differences between the groups TAHC from 6 to 12 months, indicates that this could be a possibility.
2) How precise was the process of counting the hairs?
3) is there a dose response curve publicly available for this drug?
 

petersonKj

Banned
My Regimen


lol what a joke. they failed ALL of their expectations. placebo did not get worse after 6months, it got better. CB got worse after 6 months, it was better than finasteride, now it's half as good holy sh*t. those results are absolutely sh*t, they could barely have bee worse
 

Iah11

Established Member
My Regimen
It only outperformed in the patient questionnaire. Winlevi 1% won't be useless, but it definitely won't outperform Breezula 2.5%. Also considering it's an oil-in-water (O/W) emulsion, it may be difficult to apply to the scalp.

sorry, i was looking at the 6 month efficacy data. You're right.
 

petersonKj

Banned
My Regimen
sorry, i was looking at the 6 month efficacy data. You're right.


this is the most bizarre sh*t ever. anti androgens are supposed to get better after 6 months and with time, not seriously worse. how will this look like after 2 years, 5 years? what the actual f*** did i just read.

but good for them that they are only planning 6 months, that way we can get an ineffective product even sooner
 
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