spironolactone has been proven in hundreds of studies to inhibit androgen receptors through topical application. injesting it will not help you, unless you take a lot and feminize your whole body. There are no topical side effects, unless you are sensitive to the liquid it comes in, which may have PPG. It is not strong enough to stop hair loss by itself, like propecia can, but is strong enough that it is worth taking in combo with dutasteride or propecia. It is expensive if you buy it prepared, and cheap if you make your own. It works in a different way than any other members of the big 4 (finasteride/dutasteride, nizoral, minoxidil, tricomin). The only the cream stuff is good, though it is possible that anything with PPG is good. The stuff at minoxidil.com is messy. It reacts with minoxidil to make a stink.