For smi the game is not worth the candle (estimate anyway for those who have worked hard and tried it), has a low affinity and is a competitive inhibitor, I do not remember exactly the paper where it was mentioned but with inhibitors of this type yes potentially risks worsening the situation by increasing prolactin receptors. Probably by increasing the concentration and using it for more than 6 months you will be able to concretely observe a change. If there were more targeted and related prolactin inhibitors we might try them in the future.
Hmi also creates concerns for me, not so much related to the likelihood of it not working as to the multiple implications that prolactin has. A systemic elimination could have significant side effects in the long term (something that phase 1 studies cannot detect). Prolactin for example has implications for the preservation of pancreatic cells, it is really playing with fire.
But apart from this I have found interesting studies that I can relocate in my theory, as I have tried several times to say HMI is not only important in the direction of its therapeutic use, it can make us understand something more than baldness and perhaps make us discover more paths. simple to target locally with no side effects.
These two studies introduce a significant role of prolactin in the biology of the hair follicle (as well as for stem cells in general)
www.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
These other two:
pubmed.ncbi.nlm.nih.gov
academic.oup.com
They clarify the issue even more at the cellular level. Prolactin can be a kind of "agent" put into standby of the stem cells of the follicle following the dead end that I hypothesized in the previous comments. Almost as if the prolactin came to calm the water following a stressful situation induced by the insanity of the cells and the dht, a situation that slowly however proceeds until the follicles are dead.
Prolactin is a vector, it is not a problem per se, probably HMI will work great (who knows) but given the importance that prl has in another myriad of paths I would not play with fire, especially if the fire will cost us 30k.
All that remains is to find the more specific pathways through which prolactin leads cells into apoptosis / quiescence.
Prolactin has implications with
- JAK / STAT
- BMP (specifically I think BMP4 ----> shh path)
and it certainly has some connection with androgens so I would not reject hypotheses related to a direct interaction.
Not giving any judgment before it is on the market HMI shows me however how in this industry most of the decisions are made: discovery of an element / drug / path that makes hair grow back ------> You do the tests without first yet to establish its complete functioning, thus contributing to total confusion in the pathogenesis of baldness.
Perhaps we should first of all get out of the idea that baldness is an exclusively aesthetic problem, not only because it has very evident psychological consequences but also for the fact that it is precisely starting from the development of a pathogenesis of such an intricate phenomenon that one can understand the mechanisms of a other myriad of pathologies, I have no inferiority complex for most of the companies that have tried to bring results in recent years, the empirical approach can be fine up to a certain point, after we need to deepen ...
but this is just my idea, and it doesn't apply to all scientists / entrepreneurs of course.
Hmi also creates concerns for me, not so much related to the likelihood of it not working as to the multiple implications that prolactin has. A systemic elimination could have significant side effects in the long term (something that phase 1 studies cannot detect). Prolactin for example has implications for the preservation of pancreatic cells, it is really playing with fire.
But apart from this I have found interesting studies that I can relocate in my theory, as I have tried several times to say HMI is not only important in the direction of its therapeutic use, it can make us understand something more than baldness and perhaps make us discover more paths. simple to target locally with no side effects.
These two studies introduce a significant role of prolactin in the biology of the hair follicle (as well as for stem cells in general)
Minireview: Prolactin Regulation of Adult Stem Cells
Adult stem/progenitor cells are found in many tissues, where their primary role is to maintain homeostasis. Recent studies have evaluated the regulation of adult stem/progenitor cells by prolactin in various target tissues or cell types, including the ...
www.ncbi.nlm.nih.gov
Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression - PubMed
The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects in mammals and is also found in extrapituitary sites, including murine skin. Here, we show by reverse transcriptase-polymerase chain reaction and immunohistology that, contrary to a previous report...
pubmed.ncbi.nlm.nih.gov
These other two:
Prolactin and its receptor are expressed in murine hair follicle epithelium, show hair cycle-dependent expression, and induce catagen - PubMed
Here, we provide the first study of prolactin (PRL) and prolactin receptor (PRLR) expression during the nonseasonal murine hair cycle, which is, in contrast to sheep, comparable with the human scalp and report that both PRL and PRLR are stringently restricted to the hair follicle epithelium and...
pubmed.ncbi.nlm.nih.gov
Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice*
Abstract. Pituitary PRL regulates seasonal hair follicle growth cycles in many mammals. Here we present the first evidence implicating PRL in the nonseasonal, w
academic.oup.com
They clarify the issue even more at the cellular level. Prolactin can be a kind of "agent" put into standby of the stem cells of the follicle following the dead end that I hypothesized in the previous comments. Almost as if the prolactin came to calm the water following a stressful situation induced by the insanity of the cells and the dht, a situation that slowly however proceeds until the follicles are dead.
Prolactin is a vector, it is not a problem per se, probably HMI will work great (who knows) but given the importance that prl has in another myriad of paths I would not play with fire, especially if the fire will cost us 30k.
All that remains is to find the more specific pathways through which prolactin leads cells into apoptosis / quiescence.
Prolactin has implications with
- JAK / STAT
- BMP (specifically I think BMP4 ----> shh path)
and it certainly has some connection with androgens so I would not reject hypotheses related to a direct interaction.
Not giving any judgment before it is on the market HMI shows me however how in this industry most of the decisions are made: discovery of an element / drug / path that makes hair grow back ------> You do the tests without first yet to establish its complete functioning, thus contributing to total confusion in the pathogenesis of baldness.
Perhaps we should first of all get out of the idea that baldness is an exclusively aesthetic problem, not only because it has very evident psychological consequences but also for the fact that it is precisely starting from the development of a pathogenesis of such an intricate phenomenon that one can understand the mechanisms of a other myriad of pathologies, I have no inferiority complex for most of the companies that have tried to bring results in recent years, the empirical approach can be fine up to a certain point, after we need to deepen ...
but this is just my idea, and it doesn't apply to all scientists / entrepreneurs of course.
