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Wonder when they'll test this on the first human male. Imagine being that person, would feel so amazing tbh
imagine you will be able to participate as First human males and then you get the Placebo
Wonder when they'll test this on the first human male. Imagine being that person, would feel so amazing tbh
It's probably already happened, but no one knows yet.Wonder when they'll test this on the first human male. Imagine being that person, would feel so amazing tbh
The most popular question on this forum... Safety tests have been done already on humans.how do we know this is going to be sides-free for humans?
How likely is that after 3 months of treatment Maybe 1-2years later it will Show cancer or other side effects?3 months is proven safe in humans. It only takes 6 months for it to reverse hair loss to a very significant degree. How likely is it those extra 3 months will turn out to be unsafe? Almost zero when you consider it appears to be safe in non-human primates for 6 months.
Considering the drug is being developed to treat cancer I'd say that's not likely.How likely is that after 3 months of treatment Maybe 1-2years later it will Show cancer or other side effects?
Do you feel smart now?@John Difool thought I'd answer your simple question here:View attachment 172853
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Yes - a control group of monkeys would have been really helpful. It's not because the goal is to trick some animals
You get some monkeys, randomize them into treatment/no treatment groups, and blind the humans so the results aren't tainted by any bias on the part of the researchers. This is called single blinding
In this case, that would likely (but not necessarily) mean giving placebo injections to the control group monkeys (so the humans don't figure out which of them are on the real treatment). This makes it double blinded
The point of all this is to control for things like food, temperature, lighting, human interactions, prior living conditions, selection bias on the part of humans, etc. - the possible sources of bias here would be a gigantic list
Then at the end the study (which now has high internal validity) you'd be able to show a statistical cause-effect relationship by comparing the untreated monkeys to the treated ones, and also establish effect size. And then finally results can be generalized to humans (this is called external validity)
Thats good.Considering the drug is being developed to treat cancer I'd say that's not likely.
I would pay thousands of dollars to be in the trial.Thats good.
But @pegasus2 wasnt you the guy who Said months ago that For you this 3 months human Test wouldnt be enough? Would you participate in the Phase II trials or would it be to risky For you?
He said it wouldn't be enough to determine efficacy I believe.Thats good.
But @pegasus2 wasnt you the guy who Said months ago that For you this 3 months human Test wouldnt be enough? Would you participate in the Phase II trials or would it be to risky For you?
I told you to stop quoting me. You say the same stuff over and over. I'm tired of this harassment every time I post. Perhaps I need to get the law involvedif the value of proper study controls can be openly mocked, then I view it as an opportunity to go over some of the basics of the scientific method
these exchanges matter more for 3rd parties reading them - I know I probably can't convince you of the importance of tools like peer review
the killer is that I think there's a decent chance HMI-115 works to some degree in humans, and maybe even works really well...
but that it's prudent to see if this works at least once in humans before cancelling my hair transplant procedure
Lmao, send a SWAT team this guy is being quoted on a hairloss forumI told you to stop quoting me. You say the same stuff over and over. I'm tired of this harassment every time I post. Perhaps I need to get the law involved
Good idea. Get on thatLmao, send a SWAT team this guy is being quoted on a hairloss forum
if the value of proper study controls can be openly mocked, then I view it as an opportunity to go over some of the basics of the scientific method
these exchanges matter more for 3rd parties reading them - I know I probably can't convince you of the importance of tools like peer review
the killer is that I think there's a decent chance HMI-115 works to some degree in humans, and maybe even works really well...
but that it's prudent to see if this works at least once in humans before cancelling my hair transplant procedure
Exactly. If a hair transplant will cure you then why not? If you have diffuse hair loss is a different storyIf you only need 1 hair transplant procedure then I'd just get that done instead of cancelling and hoping on something else that maybe at best is coming in 2024.
But for me hair transplant is not an option. If it was I'd go get it done now.
With translations you have to be careful. It isn't necessarily the hair loss trial they are referring to regarding FDA approval. This article isn't specific to hair loss even though it mentions it, it's about the company broadly so it could be referring to the endo trial, and probably is.产业基地启航!北大分子医学南京转化研究院产业发展基地正式启用 - 园区要闻 - 南京生物医药谷 (njbpv.cn)
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19-10-2021
HopeMedicine is an innovative biopharmaceutical company based on Professor Xiao Ruiping and his team from the School of Future Technology of Peking University, based on decades of research results in the field of translational medicine. At present, the company has completed the B round of financing, signed a global exclusive license agreement with Bayer for the development and industrialization of the monoclonal antibody HMI-115 targeting the prolactin receptor (PRLR), and is developing and industrializing multiple indications worldwide change. This antibody has the function of promoting hair growth and has a therapeutic effect on hair loss. It has shown excellent characteristics in animal models and human safety, and has obtained the approval of the US FDA Phase II clinical trial. In the near future, the US Phase II clinical trial will be launched. The patient was enrolled. In addition, Herqirui has also carried out the R&D and industrialization of more high-end innovative drugs through the dual-drive model of license-in (authorized introduction) and independent research and development.
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SOOOO they will start Phase II clinical trial for HMI-115(hair growth) now in the US