/PRNewswire/ -- Hope Medicine Inc. announced today that they have signed a world-wide exclusive license agreement with Bayer AG on the development and...
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About PRL receptor antibody
The PRL receptor antibody is a potent monoclonal antibody, blocking the PRL receptor-mediated pathway in a non-competitive manner. The drug product can be administrated subcutaneously. The antibody was well tolerated in a clinical Ph I study (combined single and multiple dosing).
The antibody was effective in stimulating hair growth in aged stump-tailed macaques, nearly doubling the number of terminal hairs after 6 months even in previously fully bald areas and showing a sustainable impact even after 2 years post treatment. Notably, the stump-tail macaque model is considered one of the rare predictive animal models for male and female pattern hair loss in humans. The study is a result of a close collaboration between Bayer scientists and researchers at IMM.
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question is whether this Phase I was only done in stump-tailed macaques or also in human?
Is it possible to do a Phase I with animals and phase II with humans ?!?!
HopeMedicine will start Phase II soon so if it is necessary to do phase I trial with human then HopeMedicine already has shown that the PRL receptor antibody was well tolerated