hair today gone tomorrow said:
Bryan...Im giving the info. that you have spouted off many times before. that is all.
Yes, I've used those same (or similar) numbers before, but YOU added something else that makes me very queezy: you specifically said that they refer to inhibition rates IN THE HAIR FOLLICLE.
I've often cited that study by Happle and Hoffmann about how "Finasteride is the main inhibitor within dermal papillae...", but what about other parts of the follicle? What if there are indeed significant amounts of the type 1 enzyme within the inner or outer root sheath, as some studies have found? That would make those stated inhibition figures inaccurate, if you're talking specifically about the ENTIRE HAIR FOLLICLE.
Those numbers you quoted are from the Gisleskog
et al studies, and are based on BODY-WIDE measurements of DHT production, and calculations and estimates of inhibition levels of the two specific enzymes. When we start talking about something as tiny as a hair follicle, we better be very cautious about using those same numbers in that context, especially when different studies have given different results about which enzymes are in which parts of the follicle. All of this is still very much a gray area, and still very controversial.
Bryan