ASC-J9 is a potent AR degrader. In vitro potency is lower than some of the newer AR degraders, but this one works in vivo and the effective in vivo dose is much lower than most other AR antagonists and SARDs(selective androgen receptor degrader). I used ASC-J9 before at 0.3%, and shortly after I noticed hairs sprouting that had been gone for 10 years. I think it's one of the most effective drugs I've used. It not only degrades the AR, it inhibts HATs which also downregulates AR transcription. Additionally, it inhibits NF-kB and Twist1. Twist1 promotes AR transcription even during AR blockade, and alters the Wnt pathway. I plan to use this drug along with CsA minoxidil and dutasteride, and probably estriol. I'm also considering halcinonide, which strongly upregulates Shh and has a good safety profile, with hair growth as a common side effect.