Applied Biology MinoxiBoost For Minoxidil NonResponders
- Thread starter -Synergy-
- Start date
- Reaction score
- 18
What do you do to improve topical minoxidil efficacy?
At least you got a response----I didn't as of yet
- Reaction score
- 106
Well right now I am using bakers p & s liquid because it exfoliates the sh*t out of the scalp. I swear I was getting results before with minoxidil and retinoic acid while routinely exfoliating. But I screwed up the first time and quit for dumb reasons. Now I am back at it hoping I can recreate the same positive response. If this isn’t good enough I will start light needling also. In addition, I might also make my skin damp before I apply the minoxidil. I will wait like 30 minutes or so after I’m done with a shower to apply. That’s three things I am thinking of to increase absorption or efficacy of anything topical.
- Reaction score
- 106
Update 6/18/21
SULT1A1 Minoxidil Response Booster Product: First Look - Follicle Thought
SULT1A1 + Minoxidil Human Study Published (Update 6/18/21) As foretold by Dr. Andy Goren below, Applied Biology has published a peer-reviewed study comparing the effect of the SULT1A1 booster in conjunction with minoxidil to minoxidil alone. The study titled “SULT1A1 (Minoxidil Sulfotransferase)...
www.folliclethought.com
Study
SULT1A1 (Minoxidil Sulfotransferase) enzyme booster significantly improves response to topical minoxidil for hair regrowth - PubMed
In a small cohort of androgenetic alopecia men, adding the SULT1A1 adjuvant to their daily minoxidil treatment regimen improved hair regrowth.
pubmed.ncbi.nlm.nih.gov
Please be legit
- Reaction score
- 2,028
I think it is more expensive than Loniten but certainly more than drinking topical.
- Reaction score
- 106
I think it is supposed to help everyone. Otherwise minoxidil sulfate is too unstable and some people claim that you have to constantly keep remaking it.
I wonder if this contains phenolics
pubmed.ncbi.nlm.nih.gov
I wonder if this contains phenolics
Effects of phenolic acids on human phenolsulfotransferases in relation to their antioxidant activity - PubMed
Sulfate conjugation by phenolsulfotransferase (PST) enzyme is an important process in the detoxification of xenobiotics and endogenous compounds. There are two forms of PST that are specific for the sulfation of small phenols (PST-P) and monoamines (PST-M). Phenoilc acids have been reported to...
pubmed.ncbi.nlm.nih.gov
cloudsanrain
Established Member
- Reaction score
- 82
I don't no if o no this but it's 2022 now .Minoxiboost is still “coming in 2021” according to their website..
We will have Follica phase 3 trials too in 2021. Last year looks very promising indeed.
Funny, in the patent they do a good job of trying to hide what it could be by discussing various angles of attack that they could sulfonate.
I did find one part about Nrf2 (sulforaphane induces it) that I have a sneaky suspicion about:
In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising an inducer of the Nrf2 nuclear factor (encoded by the NFE2L2 gene) to a hair follicle cell and/or a keratinocyte cell, i.e., agents that increase the transcription of NFE2L2. Examples of inducers are 4-Hydroxyphenylacetic acid and acetylation via p300/CBP.
In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising an agent that disassociates Nrf2 from Keapl (Kelch-like ECH-associated protein 1) to a hair follicle cell and/or a keratinocyte cell. The agent can be selected to disassociate Nrf2 from Keapl by alkylation of Keapl, or some other process. Keapl, a repressor protein, binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway. Keapl binding and subsequent promotion of the ubiquitination is the major regulatory mechanism for Nrf2 controlled genes. An example of such an agent is 4-Octyl Itaconate.
In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising a direct or indirect inhibitor of Keap 1 (either a protein inhibitor (e.g., competitive/non-competitive inhibiter of Nrf2 binding) or an agent that reduces the transcription expression of Keap 1 mRNA) to a hair follicle cell and/or a keratinocyte cell. Examples of direct inhibitors are mir-200a, RTA 408, and LH601A.
I did find one part about Nrf2 (sulforaphane induces it) that I have a sneaky suspicion about:
In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising an inducer of the Nrf2 nuclear factor (encoded by the NFE2L2 gene) to a hair follicle cell and/or a keratinocyte cell, i.e., agents that increase the transcription of NFE2L2. Examples of inducers are 4-Hydroxyphenylacetic acid and acetylation via p300/CBP.
In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising an agent that disassociates Nrf2 from Keapl (Kelch-like ECH-associated protein 1) to a hair follicle cell and/or a keratinocyte cell. The agent can be selected to disassociate Nrf2 from Keapl by alkylation of Keapl, or some other process. Keapl, a repressor protein, binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway. Keapl binding and subsequent promotion of the ubiquitination is the major regulatory mechanism for Nrf2 controlled genes. An example of such an agent is 4-Octyl Itaconate.
In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising a direct or indirect inhibitor of Keap 1 (either a protein inhibitor (e.g., competitive/non-competitive inhibiter of Nrf2 binding) or an agent that reduces the transcription expression of Keap 1 mRNA) to a hair follicle cell and/or a keratinocyte cell. Examples of direct inhibitors are mir-200a, RTA 408, and LH601A.
- Reaction score
- 892
I was reading the Regulators by Stephen King over summer and spotted at least three typos.
- Reaction score
- 106
The official website for Applied Biology => https://www.appliedbiology.com/index.html
R & D Pipeline => https://www.appliedbiology.com/AppliedBiologyPipeline.html#!
Applied Biology is headquartered in California
California Secretary of State business entity search comes back legit when you search for Applied Biology => https://bizfileonline.sos.ca.gov/search/business
When you take a closer look at the information included in the link above, it seems that the company might be going through some kind of a merger.
Maybe it is all bs or COVID took their company under.
R & D Pipeline => https://www.appliedbiology.com/AppliedBiologyPipeline.html#!
Applied Biology is headquartered in California
California Secretary of State business entity search comes back legit when you search for Applied Biology => https://bizfileonline.sos.ca.gov/search/business
When you take a closer look at the information included in the link above, it seems that the company might be going through some kind of a merger.
Maybe it is all bs or COVID took their company under.
Yes I hope they are legit but this sh*t was thought to be coming out when I first joined this forum, still no development in like a year and a half, this would be a massive win for me if they released it
- Reaction score
- 146
It seems that "Applied Biology" no longer exists.
http://www.minoxistyle.com/ now takes you to a suspended page.
https://www.appliedbiology.com/index.html isn't accessible.
It appears they've been acquired by https://jupiterwellness.com/products/hair-loss/
Product
Topical treatment designed to improve Minoxidil efficacy.
Studies
Clinically shown to increase the enzymes needed for minoxidil to work, sulfotransferase enzymes, by up to 7x over a two-week period.
Sales Channels
Licensed to Taisho, a $2.6 billion revenue company and Japan’s leading seller of minoxidil products. A $300k up-front payment was received with 3% royalties on net sales. They expect to launch the product commercially in 2023.
Licensed to India-based Cosmofix Technology and Sanpellegrino Cosmetics. A $50k up-front payment was received with 10% royalties on net sales. The timeframe for their commercial product launch has not been established.
Next Steps
Additional licensing opportunities are being pursued abroad.
http://www.minoxistyle.com/ now takes you to a suspended page.
https://www.appliedbiology.com/index.html isn't accessible.
It appears they've been acquired by https://jupiterwellness.com/products/hair-loss/
Product
Topical treatment designed to improve Minoxidil efficacy.
Studies
Clinically shown to increase the enzymes needed for minoxidil to work, sulfotransferase enzymes, by up to 7x over a two-week period.
Sales Channels
Licensed to Taisho, a $2.6 billion revenue company and Japan’s leading seller of minoxidil products. A $300k up-front payment was received with 3% royalties on net sales. They expect to launch the product commercially in 2023.
Licensed to India-based Cosmofix Technology and Sanpellegrino Cosmetics. A $50k up-front payment was received with 10% royalties on net sales. The timeframe for their commercial product launch has not been established.
Next Steps
Additional licensing opportunities are being pursued abroad.