An Updated View On Upcoming Treatments | Page 2 | HairLossTalk Forums

An Updated View On Upcoming Treatments

Discussion in 'New Research, Studies, and Technologies' started by Iah11, Mar 3, 2018.

  1. MrV88

    MrV88 Experienced Member My Regimen

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    Xander would be ready for making your firstborn...

    Think of it that way:

    Either Shiseido could immunize your hair than Tsuji could clone it

    Or

    Tsuji could clone your fucked up hair and Shiseido could immunize it after implenting

    Or

    Tsuji could clone your fucked up hair and alter it to the point where it won't diminish again?

    Seems like an option for you
     
    Georgie likes this.
  2. Georgie

    Georgie Senior Member My Regimen

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    All involves much money and flying to japan and probably waiting in a 10-year queue. I would kill for this though.
     
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  3. MrV88

    MrV88 Experienced Member My Regimen

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    Try killing FOR it and not yourself.

    The day we lose our hope around here is probably the day that we kill ourselves. Still better than nothing in your special case
     
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  4. Georgie

    Georgie Senior Member My Regimen

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    I feel like I will have given up by the time all this stuff is available.
     
  5. Iah11

    Iah11 Established Member My Regimen

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    I realise I've actually missed a couple of important things.

    PolarityTE is an unknown quantity. It aims to regenerate wounded skin to take on the appearance of the healthy surrounding skin (of which a biopsy has been taken to create the 'new' skin). Their preclinical research showed success in pigs and it is confirmed to be in use in several US hospitals. The use of autologous cells means the treatment skips typical phase 1/2/3 testing. Interestingly, they have claimed that initial human results have shown the regeneration of full thickness "hair-bearing" skin. They are on record saying they will pursue a hair related product. We dont really know though. They are aiming to release clinical data in the next 3 months. The science is solid, preclinical data is solid, recent acquisition of a new 700,000 square foot facility, publicly traded company.

    Honestly at this point, a 5 year timeline seems pessimistic for a new treatment to come out.
     
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  6. Timii

    Timii Established Member My Regimen

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    It's like life is challenging me to maintain my hair until new treatments come out
     
  7. That Guy

    That Guy Senior Member My Regimen

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    You've probably said somewhere, but have you been to a doctor about that?

    I mean, that just seems like there's a deeper problem than garden-variety hairloss if you're losing body hair as well.
     
  8. kingjohn

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  9. Georgie

    Georgie Senior Member My Regimen

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    Yes I have and I’ve been diagnosed. It’s a fairly easy concept to grab. When sex hormones decline, body hair gets thinner, when you don’t have enough estrogen to counteract androgens, your scalp hair gets thinner.
     
  10. Willy Shakespeare

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    I desire thou art right, mate! I tenderly comb mine pubic hair everyday with that desire...
     
  11. Georgie

    Georgie Senior Member My Regimen

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    Dafuq
     
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  12. GVTAR

    GVTAR New Member My Regimen

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    From their website

    "If successful in the burn market, we plan to explore entry into other markets, such as acute and chronic wounds, cosmetic/scar revisions, and hair regeneration."

    Emphasis added
     
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  13. Jesse Navarro

    Jesse Navarro Established Member My Regimen

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    Get out of here Willy, look at my beautiful hair. Envy me.

    christopher-marlowe-wc-9399572-1-402.jpg
     
  14. Iah11

    Iah11 Established Member My Regimen

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    Interesting. Theres an interview from last year in which a member of their team states they were already working on optimising a hair loss product. I would like to know why the product couldnt be used after a FUT procedure to heal the scar, with added hair. Like a hair cloning product?

    Also added note: the Tsuji Organ Regeneration website actually states trials are being targeted for this year. Theyre very confident in their tech it seems.
     
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  15. baldco

    baldco New Member My Regimen

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    I think this is only published 2 days ago, I can't find this on sci-hub. Involves JAK-STAT5
    From
    Author(s):Wang, Etienne Cho Ee
    Thesis Advisor(s): Christiano, Angela M.
    Date: March 2018

    "distinct subset of TREM2+ macrophages predominate during early- and mid-telogen, where they produce Oncostatin M (OSM), which is sufficient to maintain quiescence of hair follicle stem cells (HFSCs). Proliferation of HFSCs and hair growth is associated with depletion of this subset of TREM2+ macrophages. Interestingly, macrophage markers and OSM were found to be upregulated in the balding scalp of males with androgenetic alopecia, suggesting that this mechanism is physiologically relevant in the control of human hair cycling."


    "The mechanism through which OSM exerts this effect is via JAK-STAT5 signaling downstream of the OSM receptor, which is antagonized by pharmacological JAK inhibition. Conditional epidermal ablation of OSMR or STAT5 during early- and mid-telogen (P42 – P60) shortens the telogen phase significantly, and inhibition of macrophages by way of neutralizing antibodies, small molecule inhibitors, and genetic ablation (with Csf1r-CreER::R26-iDTR mice) during telogen also promotes hair growth. "


    I know Folicium is doing something with OSM and had good results
     
    #35 baldco, Mar 9, 2018
    Last edited: Mar 9, 2018
  16. dermrafok

    dermrafok Established Member My Regimen

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    Aclaris experimental hair loss treatment gets additional patent protection

    https://www.bizjournals.com/philade...-hair-loss-jak-inhibitor-patent-columbia.html

    U.S. patent number 9,895,301 covers the use of tofacitinib, a JAK inihibitor, for inducing hair growth and for treating hair loss disorders such as alopecia areata and androgenetic alopecia — otherwise known as male/female pattern hair loss.

    Current treatments are so ineffective that's why the market fiercely launches into new treatments for androgenetic alopecia. That's....business...Just saying.
     
    #36 dermrafok, Mar 9, 2018
    Last edited: Mar 9, 2018
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  17. Georgie

    Georgie Senior Member My Regimen

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    WE’LL TAKE THE LOT
     
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  18. Iah11

    Iah11 Established Member My Regimen

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    Good find but this is why i struggle to have faith in a treatment such as a JAK inhibitor being better than finasteride. A JAK inbibitor will prevent this particular mechanism (shorter hair cycle) but how does it affect all the other pathological insults that arise from DHT binding the AR? In my view, succesful upcoming treatments for regrowth should focus on neogenesis/healing.
     
  19. Iah11

    Iah11 Established Member My Regimen

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    UPDATE ON THE OP

    1) Follica pipeline was updated in the last few weeks. The bar has now completed Phase 2. Speculation that the pre pivotal trial has completed and that the beginning of phase 3 is very, very imminent.

    2) RCH-01 was named as a key product in Shiseido's new three year plan to increase its revenues, on its website. It is stated "we will not only produce innovation in cosmetics but also build innovative business models and explore new frontiers such as artificial skin, hair and skin regeneration", showing that they haven't forgot about it but it's thought of as an important part of their plans to increase revenue. The trial is finished now. I'm pretty confident it will be out in 2019 at some point.

    3) Brotzu is a scam.

    4) Setipiprant data readout planned for March 2019, although I don't believe this will get released.

    5) The Tsuji team released a press statement in which it is claimed all hurdles to hair multiplication in humans have now been solved in the lab (including the mythical inductivity problem) and this is ready to leave the preclinical stage. Human trials are definitively scheduled for March 2019, on the condition that the newly commenced mouse studies don't show carcinogenesis. This genuinely is the holy grail of hair loss and its tantalisingly close!

    6) Surprisingly, no updates on PTD-DBM. There was a study released that showed the benefits of the substance with VPA. Still waiting on the conference in August, where the lead researcher is present. Hopefully a lot of new info there and ideally news of human trial..

    Almost halfway through 2018 and everything is going... surprisingly well? Tsuji team no longer seems like a fantasy, Follica are still marching on, RCH-01 is being talked of positively by Shiseido, Samumed planning on an unexpected Phase 3. The end is near boys, we're so close now!!
     
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  20. AnArcticTaco

    AnArcticTaco Established Member My Regimen

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    Is it possible we could see RCH-01 by the end of 2018?
     
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