An Updated View On Upcoming Treatments | HairLossTalk Forums

An Updated View On Upcoming Treatments

Discussion in 'New Research, Studies, and Technologies' started by Iah11, Mar 3, 2018.

  1. Iah11

    Iah11 Established Member My Regimen

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    So the clinical research pipeline post on this site is very useful, but by now its very outdated.

    Histogen is almost certainly a scam. Bimatomoprost isnt ever coming to market as a hair loss drug, possibly because it isnt much more effective than minoxidil. Samumed failed to surpass finasteride results, and has since gone silent so its probably never going to come out.

    Aside from these failures, theres many reasons to think this is the most pivotal year in hair loss history.

    1) Follica is confirmed to be in the final prepivotal stage that was promised last year. A phase 3 trial is scheduled to start in the next 6 months. They have recently secured funding. The website boasts of hair follicle neogenesis and efficacy that is 3-4x that of current treatments.

    2) Shiseido is scheduled to report on its trial results, in the next 3 months. Replicel claimed a 2 year stabilisation of hair loss in all patients following 1 injection in their own phase 1 study.. I dont much trust replicel as a legitimate company but im hopeful this treatment will come to market (in Japan only) in the next 12 months. This is based on the investment Shiseido undertook on buying a cellular research lab allowing improvements on Replicels methods and results, the wording of certain emails, the breach of contract with replicel meaning Shiseido can waive the milestone royalty payments.

    3) Brotzu lotion. At this point its a meme of course. But rumours are that FIDIA will report on Androgenetic Alopecia trial results in a months time in a conference. It doesnt seem to be a good chance based on comments like "reversing 5 years of hair loss" by the doctor behind the lotion. Very sensationalist and unproven claim. Here's hoping.

    4) Setipiprant will almost certainly never come out, just because I dont believe PGD2 inhibition will ever beat finasteride. The Seti trial itself removed the finasteride group, most likely because the comparison would not be favourable. The good news is Fevipirant will (probably) be available in 2020 as an asthma treatment. It was supposed to be out next year but the trial got extended. Maybe to allow more time to show statistically significant efficacy? Fevi is the dutasteride to setipiprant's propecia.

    5) The Tsuji team released a study at the start of this year in which the successful cloning of hair follicles was mentioned yet again. In private communications with HairLossTalk.com members, it was also claimed the inductivity problem was solved as well. First in human trials were claimed to be beginning in early 2019. Info should be coming regarding that at some point this year.

    6) A korean team led by a world renowned researcher discovered a peptide that stops the negative inhibition of wnt signalling in hair loss, allowing hair regeneration. It is a patented substance that worked on scarred human skin that was grafted on mice. The findings are supposedly going to be presented at a conference in June. A mysterious reddit user claimed human studies have already begun. This seems like a lie to me, however, he reported on the study before it was even released to journals and the media, so his reliabilty has been proven once at least. Definitely the most promising at-home hair loss treatment of the bunch, but it all depends on when it will be tested on humans.

    By December, we could be on the brink of the first efficacious hair loss treatment in 30 years. We could be on the brink of multiple. Or... everything could fall apart. Either way, 2018 is the most pivotal year in hair loss treatment ever.
     
    Headdy, razzmatazz91, Jimm and 28 others like this.
  2. Pigeon

    Pigeon Established Member My Regimen

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    Good thread, looking forward to the official seti and shiseido trial results in a few months.

    And I completely agree, 2018 is probably the most important year in hair loss treatment ever.
     
    Iah11 likes this.
  3. occulus

    occulus Experienced Member

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    I've brought this up before, but nothing changed. I don't know what's wrong with updating that chart.
     
  4. fuDHTck

    fuDHTck Established Member My Regimen

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    Add Polichem finasteride and Breezula.

    Both are running big studies (400+ people) and will be interesting to see the results. Actually polichem finasteride should be almost done..
     
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  5. Dalex

    Dalex New Member My Regimen

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    New account. Forgot old details but I have been around since neosil was the next big hopet thing days. I dont understand how Histogen became a bust or why people just say it is. last I recall they had 78% hair increase in patients. I realize you need to take into account how much density a person is starting with but they seemed like our best hope not that long ago.

    I have given up trying to follow all the latest "next things" as its exhausting trying to stay informed. I really hope Follica or replicel/shisedo is an injection of cells or something ( Educate me on this if you are so kind). I strongly believe we cant achieve optimal results with hair transplant style implantation even if we create unlimited donor. the hairs just dont grow properly. direction and texture is always very different then a normal persons hair.

    For myself. histogen would have basically cured me to the point of feeling good enough I would be done worrying about hair loss. 30cm2 increase treatment I think ill be happy. anything near 50 and im almost positive id be cured..

    Just my 2cents. Pls no hate.
     
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  6. Iah11

    Iah11 Established Member My Regimen

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    Great point. I suppose I left off Polichem because I personally dont get side effects from my finasteride dose currently. Unfortunately i dont get any therapeutic benefit either. Is there reason to believe topical finasteride will be better at inhibiting scalp DHT?

    Breezula is great though, relatively far away though. 4 years until commercialisation is planned. The acne formulation could be used on scalp though surely. I think in 3 years time, only the most unlucky men should ever have to lose their hair. This is because I think a combo of finasteride (topical or oral)/dutasteride, fevipirant and cb-03-01 should be almost insurmountable.

    With that combo scalp DHT could be lowered by 30-60% by finasteride. CB-03-01 is supposedly a sideless androgen receptor blocker that should prevent a significant proportion of the remaining DHT binding to the Androgen Receptor. For the DHT that does manage to bind to the AR, fevipirant will block the enzyme that produces, one of the most important mediators of hair growth inhibition-pgd2.

    Reason why Histogen is a scam is their before and after photos were awfully dodgy. Track them down if you fancy it. At the same time, they have pushed back release over and over with no trial in sight still. Add to this that for some reason they only want to trial it in Mexico first. It doesn't sound like the actions of a company that could deliver 80% increase in density.
     
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  7. Georgie

    Georgie Senior Member My Regimen

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    I’m hoping Tsuji/replicel come through for the DUPA/retrograde/diffusers. That’s if we have any hair left to clone by then.
     
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  8. Hate da Bt

    Hate da Bt Established Member My Regimen

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    What about Aclaris and JAK inhibitors?
    Phase II trials are being conducted and results are to be reported next year.
     
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  9. Bitless

    Bitless Experienced Member My Regimen

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    This is my personal idea for dupa patients and the cure. So dht grows hair for every single body part except for hair. So for dupa patients, what if tsuji and reprlicel duplicate beard or any other hair that’s not from head. And they inject into the hair and it will grow much more easily and thick. It just my thought. Since it’s possible to transplant hairs from body part to head.
     
  10. Alternative

    Alternative Established Member My Regimen

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    Yes, Brotzu 5 years of reversal sound like a marketing strategy, but then I think that he is referring to special cases.
    For young guys minoxidil + finasteride could give mega regrowth, the same mega regrowth could apply here.
    Also, estrogen could grow new hairs on very old men, what Brotzu is using? Plant estrogen, you may say it has sides, but for some reason in some studies it is pointed that it helps to improve sexual health of men and Brotzu clan said no side, but who knows? What is important to note that Brotzu said that he tested lotion on Androgenetic Alopecia which lasted more than 20 years (slick bald) and it revived some hair, when an old man was using estrogen it also revived only some hair, but not all.

    So it may be snake oil, it may be something that works. If this works better than Minoxidil and Finasteride, but not that great you would still benefit since then it will save your ass before Shiseido and Follica comes out if they even come out or get delayed (yes, this is wishful thinking).

    If the meme becomes reality, then le lozione Brotzu could be potent enough to turn those vellus hairs per square cm that Follica gives into terminal.
     
    #10 Alternative, Mar 4, 2018
    Last edited: Mar 4, 2018
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  11. That Guy

    That Guy Senior Member My Regimen

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    Jesus fucking Christ, it's refreshing to see a thread on here that just lays out where shit is at and accepts it without complaining that it's too far away or going into some rabbit hole of doubt just for the sake of venting.

    Have a like.

    No, fuck it

    machine-gun-facebook-like1-5466515002508.png
     
  12. Stupidon

    Stupidon Established Member

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    1. Nothing new
    2. You don’t trust Replicel. Fair enough. Shisheido is only using Replicel tech. Just so you know, it took 2 years to Shisheido to get the green light for the trial. They need to collect data + interpret + present + submit for approval. « 2018 » ... lol
    3. Your interpretation of rumours. Wait for official statement. They did not promise anything so far.
    4 & 6. Irrelevant.
    5. Nothing new.
     
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  13. Georgie

    Georgie Senior Member My Regimen

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    Well I’m female so I guess I’m fucked if that logic is correct
     
  14. Iah11

    Iah11 Established Member My Regimen

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    Tbh, JAK inhibitors have been tried at high doses for a while, even orally, for other conditions. JAK-STAT signalling is definitely altered in Androgenetic Alopecia, but I fail to see them being very successful. I could be wrong of course.

    Jeez, you're a barrel of laughs. Point wasn't to provide groundbreaking info, the point was to compile detailed and recent info on all the big players and put it in one place.
     
  15. MrV88

    MrV88 Experienced Member My Regimen

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    Let's say Shiseido could immunize your hair than Tsuji could clone it right?
     
  16. Bitless

    Bitless Experienced Member My Regimen

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    You are not. If my theory works out, any kind of balldness that effects by dht will be cure since any body part hair excpet for sclap hairs are grows by dht. So if it’s right and it can be done, then you are good as we all are
     
  17. d3nt3dsh0v3l

    d3nt3dsh0v3l Experienced Member My Regimen

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    It may be possible to extract resistant follicles FUE style, so long as there are enough remaining (~100?). This is just speculation on my part, but there should always be some hair remaining. Even in traditional male pattern baldness regions, there will be an occasional confused follicle thriving between its dying neighbours.
     
    #17 d3nt3dsh0v3l, Mar 4, 2018
    Last edited: Mar 4, 2018
  18. Chap1

    Chap1 Member My Regimen

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    I am looking forward to the next five years... Interesting stuff going on! Some of these may be what we need.
     
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  19. Georgie

    Georgie Senior Member My Regimen

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    Yeah but I also have menopausal style body hair thinning. All over my body.
     
  20. Georgie

    Georgie Senior Member My Regimen

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    I would sell my first born if I had a first born.
     
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