AMPK ROUTE / METFORMIN AKG THE MAX SUMMARY

[tato123]

Max summary of Metformin/AKG. AMPK and TORm receptor

I posted this on the forum elsewhere but I see that there is a lot of doubt around this subject, I decided to make this topic for this information to be better exposed, since they are important for our community

Alpha-Ketoglutarate: Physiological Functions and Applications

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein ...

www.ncbi.nlm.nih.gov

"""A recent study has shown the potential usefulness of AMPK treatment in preserving bone mass as well as lowering bone turnover in post-menopausal women (Tocaj et al., 2003). Results suggest a link between enteral AKG/AMPK and an increase in estrogen levels. """ (in my opnion maybe higher i little or regulates receptor(AR or ER) I have already posted some studies in other posts where the AMPK pathway regulates AR receptors , wathever maybe AMPK pathway modulates estrogen levels,


It appears that high levels of AMPK response result in high levels of estrogens are somehow still unclear how levels of estrogens can higher.

Explains the effect of metformin on acne, on hinsurtism, skin's diseases , In addition to the effects of AMPK / AKG stimulation , estrogen being an "anti androgen" by definition and studies pointing to this side explain a lot its off-label therapeutic effect.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778205/ (Metformin off label )




High levels of AMPK BURST will compel your follicles to enter the anagen phase

Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles - PubMed

Mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and survival. There is limited evidence that mTOR influences hair follicles (HFs), which undergo cycles of quiescence (telogen), growth (anagen) and regression (catagen). We sought to investigate whether mTOR, in...

pubmed.ncbi.nlm.nih.gov

Stimulation of Hair Growth by Small Molecules that Activate Autophagy - PubMed

Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions worldwide, but methods that can be used to regrow hair are lacking. We report that quiescent (telogen) hair follicles can be stimulated...

pubmed.ncbi.nlm.nih.gov

mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration - PubMed

Hair follicles (HFs) undergo cycles of degeneration (catagen), rest (telogen), and regeneration (anagen) phases. Anagen begins when the hair follicle stem cells (HFSCs) obtain sufficient activation cues to overcome suppressive signals, mainly the BMP pathway, from their niche cells. Here, we...

pubmed.ncbi.nlm.nih.gov

Stimulation of Hair Growth by Small Molecules that Activate Autophagy

Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects …

www.sciencedirect.com

It has a direct effect on the hair follicle in several different paths .

It can be an unprecedented therapeutic drug for your capillary and skin health, in a way you never dreamed of, I saw a lot of things that scared me with results, but it's not all flowers, is it?

This pathway interferes with glutamine metabolism

The AMPK pathway increases the availability of glutamine, so to speak.

Glutamine has great effects on the body, macrophages and other cells of our immune and muscular system.

However, in the brain it can have adverse effects on (swelling of astrocytes, defects in neuronal communication) this is how severe liver conditions develop .

Glutamine is metabolized to ammonia, this is too toxic for the kidneys and liver , besides everything and in addition we can enter an eternal cycle of ammonia to hyperstimulate this pathway

Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy–therapeutic perspectives

There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in skeletal ...

www.ncbi.nlm.nih.gov

AMPK Activation Affects Glutamate Metabolism in Astrocytes - PubMed

Mammalian AMP-activated protein kinase (AMPK) functions as a metabolic switch. It is composed of 3 different subunits and its activation depends on phosphorylation of a threonine residue (Thr172) in the α-subunit. This phosphorylation can be brought about by 5-aminoimidazole-4-carboxamide...

pubmed.ncbi.nlm.nih.gov

And stimulate the catabolism acids BCAA's; valine, leucine and isoleucine in skeletal muscle .

The post will be gigantic if I go on explaining it, but I can already tell, I just say that stimulating the AMPK route can be wonderful for skin and hair, but this is the contract, this in the long term 10 years for example can evolve something bad .

In other words, make your choice via AMPK worth it or not?

EFFECT BOOST ANTI ANDROGEN

The anticancer potential of metformin on prostate cancer - Prostate Cancer and Prostatic Diseases

Prostate cancer (PCa) is characterized as the most frequent type of cancer in males. Recent research has suggested patients who have diabetes mellitus taking metformin (MF) have a lower risk of PCa. MF has antineoplastic effects such as adenosine monophosphate-activated protein kinase...

www.nature.com

https://www.tandfonline.com/doi/abs/10.3109/09513590.2014.951321

Metformin enhances the antiproliferative and apoptotic effect of bicalutamide in prostate cancer - PubMed

Combining bicalutamide and metformin significantly reduces prostate cancer cell growth further than either monotherapy. In AR-positive cells, this effect appeared to be mediated by reducing proliferation rates, whereas in AR-negative cells the combination treatment appeared to promote apoptosis...

pubmed.ncbi.nlm.nih.gov

Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration

Purpose: Inflammatory infiltration plays important roles in both carcinogenesis and metastasis. We are interested in understanding the inhibitory mechanism of metformin on tumor-associated inflammation in prostate cancer. Experimental Design: By using a transgenic adenocarcinoma of the mouse...

clincancerres.aacrjournals.org

COMPARISON OF FINASTERIDE, METFORMIN, AND FINASTERIDE PLUS METFORMIN IN PCOS

The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin ...

www.ncbi.nlm.nih.gov

Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT - Cell Death & Disease

Although the newly developed second-generation anti-androgen drug enzalutamide can repress prostate cancer progression significantly, it only extends the survival of prostate cancer patients by 4–6 months mainly due to the occurrence of enzalutamide resistance. Most of the previous studies on AR...

www.nature.com

 

[JaneyElizabeth]

Max summary of Metformin/AKG. AMPK and TORm receptor

I posted this on the forum elsewhere but I see that there is a lot of doubt around this subject, I decided to make this topic for this information to be better exposed, since they are important for our community

Alpha-Ketoglutarate: Physiological Functions and Applications

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein ...

www.ncbi.nlm.nih.gov

"""A recent study has shown the potential usefulness of AMPK treatment in preserving bone mass as well as lowering bone turnover in post-menopausal women (Tocaj et al., 2003). Results suggest a link between enteral AKG/AMPK and an increase in estrogen levels. """ (in my opnion maybe higher i little or regulates receptor(AR or ER) I have already posted some studies in other posts where the AMPK pathway regulates AR receptors , wathever maybe AMPK pathway modulates estrogen levels,


It appears that high levels of AMPK response result in high levels of estrogens are somehow still unclear how levels of estrogens can higher.

Explains the effect of metformin on acne, on hinsurtism, skin's diseases , In addition to the effects of AMPK / AKG stimulation , estrogen being an "anti androgen" by definition and studies pointing to this side explain a lot its off-label therapeutic effect.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778205/ (Metformin off label )




High levels of AMPK BURST will compel your follicles to enter the anagen phase

Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles - PubMed

Mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and survival. There is limited evidence that mTOR influences hair follicles (HFs), which undergo cycles of quiescence (telogen), growth (anagen) and regression (catagen). We sought to investigate whether mTOR, in...

pubmed.ncbi.nlm.nih.gov

Stimulation of Hair Growth by Small Molecules that Activate Autophagy - PubMed

Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions worldwide, but methods that can be used to regrow hair are lacking. We report that quiescent (telogen) hair follicles can be stimulated...

pubmed.ncbi.nlm.nih.gov

mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration - PubMed

Hair follicles (HFs) undergo cycles of degeneration (catagen), rest (telogen), and regeneration (anagen) phases. Anagen begins when the hair follicle stem cells (HFSCs) obtain sufficient activation cues to overcome suppressive signals, mainly the BMP pathway, from their niche cells. Here, we...

pubmed.ncbi.nlm.nih.gov

Stimulation of Hair Growth by Small Molecules that Activate Autophagy

Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects …

www.sciencedirect.com

It has a direct effect on the hair follicle in several different paths .

It can be an unprecedented therapeutic drug for your capillary and skin health, in a way you never dreamed of, I saw a lot of things that scared me with results, but it's not all flowers, is it?

This pathway interferes with glutamine metabolism

The AMPK pathway increases the availability of glutamine, so to speak.

Glutamine has great effects on the body, macrophages and other cells of our immune and muscular system.

However, in the brain it can have adverse effects on (swelling of astrocytes, defects in neuronal communication) this is how severe liver conditions develop .

Glutamine is metabolized to ammonia, this is too toxic for the kidneys and liver , besides everything and in addition we can enter an eternal cycle of ammonia to hyperstimulate this pathway

Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy–therapeutic perspectives

There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in skeletal ...

www.ncbi.nlm.nih.gov

AMPK Activation Affects Glutamate Metabolism in Astrocytes - PubMed

Mammalian AMP-activated protein kinase (AMPK) functions as a metabolic switch. It is composed of 3 different subunits and its activation depends on phosphorylation of a threonine residue (Thr172) in the α-subunit. This phosphorylation can be brought about by 5-aminoimidazole-4-carboxamide...

pubmed.ncbi.nlm.nih.gov

And stimulate the catabolism acids BCAA's; valine, leucine and isoleucine in skeletal muscle .

The post will be gigantic if I go on explaining it, but I can already tell, I just say that stimulating the AMPK route can be wonderful for skin and hair, but this is the contract, this in the long term 10 years for example can evolve something bad .

In other words, make your choice via AMPK worth it or not?View attachment 160421

How hard is metformin to get and how expensive is it?

 

[tato123]

Hi janey, good to see you.

In my country it is very cheap and easy to get a box of 30 pills costs about 5 dollars

 

[GabberHead]

Will you try this? Will this work topically?

 

[tato123]

Will you try this? Will this work topically?

I say that this does not work topically, if you read the articles I posted you can see that the topical use of metformin causes different effects from the systemic effect via inhibition of adenosine phosphatase, I will not explain because this will be turn in a giant post, but metformin should not be used topically for hair loss or acne.

Metformina boost efect increases the effects of anti androgens, there are several studies that say that, in addition to its anti-aging, anti-aging effect via AMPK.

It is an immunomodulator too , it has a lot of content there, take a calm look.

Peace buddy

 

[tato123]

Yes I use 500mg a day.

 

[Pls_NW-1]

Yes I use 500mg a day.

How do you deal with the sides now?
Actually, 1000 mg is the normal dose lol

 

[tato123]

How do you deal with the sides now?
Actually, 1000 mg is the normal dose lol

Sometimes I take 1000 mg a day. This drug acumulates in tissues

Its dosage is high we can reach up to 2000 mg per day.

But as I said in my posts in other parts of this forum it causes me some bad side effects, so I try to keep your dose as low as possible 500 mg is the minimum dose for treatment effective .

After I started taking metformin I started to see results, but I am still taking many other things so I don't know if the effect was just hers.

I am having results after I started it, maybe meaning it is helping.

 

[Pls_NW-1]

Sometimes I take 1000 mg a day. This drug acumulates in tissues

Its dosage is high we can reach up to 2000 mg per day.

But as I said in my posts in other parts of this forum it causes me some bad side effects, so I try to keep your dose as low as possible 500 mg is the minimum dose for treatment effective .

After I started taking metformin I started to see results, but I am still taking many other things so I don't know if the effect was just hers.

I am having results after I started it, maybe meaning it is helping.

Your case again proves that hormones / sensitivity due to genes are mostly the cause of hair loss. Thank you for your contribution, our warrior!!

 

[tato123]

Thank you my friend, I'm happy to glad to be able to help a little

 

[Get my hair back]

Yes I use 500mg a day.

Hello. You say that the minimum dose is 500mg but can this dose depend on the weight of the person? For example, my weight is 60 kilograms, as you think it will be enough to take 250 mg/day. And metformin can be normal and prolonged action such as GLUCOPHAGE LONG what kind of metformin do you recommend?

 

[trialAcc]

Hi janey, good to see you.

In my country it is very cheap and easy to get a box of 30 pills costs about 5 dollars

Metformin is cheap, but good luck getting a prescription from a doctor to use it for hairloss. While not all sides are serious, this drug causes many minor noticeable sides.

There is also basically 0 evidence here that it would have any effect on hairloss other then in theory. The study you presented with finasteride are on women.

 

[tato123]

Hello. You say that the minimum dose is 500mg but can this dose depend on the weight of the person? For example, my weight is 60 kilograms, as you think it will be enough to take 250 mg/day. And metformin can be normal and prolonged action such as GLUCOPHAGE LONG what kind of metformin do you recommend?

Hi, I do not recommend anything, I just posted for you to see and draw your own conclusions.

Any long-acting metformin like the one you mention can improve the potential side effects.

The dose does not depend on size and weight, the minimum dose to start is 500mg normally.

 

[tato123]

Metformin is cheap, but good luck getting a prescription from a doctor to use it for hairloss. While not all sides are serious, this drug causes many minor noticeable sides.

There is also basically 0 evidence here that it would have any effect on hairloss other then in theory. The study you presented with finasteride are on women.

I also read my articles, I know what I posted, but you know, I posted it for checking the mechanism of action IN HUMANS , there are no studies on metformin for hair loss, all of this is speculative, we don't have millions of dollars to develop research.
I only gathered information that may be relevant to the community.

I posted to the community not just for middle aged men who suffer from hair loss , have womens here too .

 

[tato123]

Metformin is cheap, but good luck getting a prescription from a doctor to use it for hairloss. While not all sides are serious, this drug causes many minor noticeable sides.

There is also basically 0 evidence here that it would have any effect on hairloss other then in theory. The study you presented with finasteride are on women.

Have you seen her studies with bicalutamide and the other androgens?

I say in post BOOST anti androgen effect

It has been shown to increase AA effect on the AR receptor in male studies.

Read the posts better to avoid embarrassment.

If you take metformin alone you obviously won't do anything, study analyze what you are reading, it discourages me a little to participate in these forums, it's a long time explaining to lazy people

 

[trialAcc]

Have you seen her studies with bicalutamide and the other androgens?

I say in post BOOST anti androgen effect

It has been shown to increase AA effect on the AR receptor in male studies.

Read the posts better to avoid embarrassment.

If you take metformin alone you obviously won't do anything, study analyze what you are reading, it discourages me a little to participate in these forums, it's a long time explaining to lazy people

I'm not embarrassed about anything I posted, I'm just questioning it's benefit because I know family members who take metformin for diabetes and it's not an easy drug to take long term without side effects.

 

[tato123]

I'm not embarrassed about anything I posted, I'm just questioning it's benefit because I know family members who take metformin for diabetes and it's not an easy drug to take long term without side effects.

I agree is a very serious decision, it is another drug in its therapeutic scheme, it will certainly have risks, but we have evidence that it lowers levels of circulating androgens and somehow potentiates the effects of Anti androgens on the receptor, something curious, it is anti cancer too , anti age, i decided to try, but all of this is speculative, as i said this is just a summary summary of information i managed to collect.

Peace my friend

 

[telogen]

i've been doing 1000 mg for three years for anti-aging reasons (im not diabetic). It helps leaning out the body, but not much else as far as i can tell. No sides.

 

[trialAcc]

i've been doing 1000 mg for three years for anti-aging reasons (im not diabetic). It helps leaning out the body, but not much else as far as i can tell. No sides.

Do you get it prescribed by your doctor or self sourced?

 

[telogen]

Doctor. No issue getting it. The drug is considered very safe here in norway.