all the finasteride hate, can anyone use science to explain this question...

jksl

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It's true, I was definitely scared of finasteride. Now I am approaching a strong Norwood 1. I genuinely hate scare mongering. It nearly got me.
Did you even try finasteride before resorting to RU? Though, RU is 100% safe, according to anecdotes I have read on here...


Your brain must be foggy or something from the finasteride, but i never touched RU.
Given the fact that you don't know what placebo means, I don't expect you to have a "real explanation"
 

qerqrqwrqwr

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The good news is, if you believe finasteride can cure cancer,

the placebo effect kicks in,

and you can cure cancer and reverse hair loss at the same time
 

eenrak

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Your brain must be foggy or something from the finasteride, but i never touched RU.
Given the fact that you don't know what placebo means, I don't expect you to have a "real explanation"

I agree, it wasn't a correct usage of placebo. But don't you agree that different illnesses have different drug targets that inhibit/activate, whatever the drug targets? Without looking into the literature for mechanisms and whatnot, it is obvious to me that we are talking about different mechanisms with different response times.

Seriously, I hope that you find a method that works for you without side effects.
All these hopeless guys trying to catch a break, just to be scared off by possible, but unlikely adverse effects is really depressing. If there were no treatments available, it would be easier to accept baldness, because there would never be a 'what if I tried..'.
I don't want to make anymore comebacks. If you are losing hair and not fighting it out of fear, I genuinely feel sorry for you.

Sorry for high jacking the thread OP.
 

Spanishlad

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I know you don't so I pasted so you can http://www.pfsfoundation.org/news/c...-a-harvard-medical-school-teaching-affiliate/

The Post-Finasteride Syndrome Foundation today announced the funding of a major clinical study on post-finasteride syndrome (PFS) at Brigham and Women’s Hospital (BWH), a teaching affiliate of Harvard Medical School.
Titled “A Preliminary, Hypothesis-Generating Investigation of the Post-Finasteride Syndrome: Description of the Phenotype, and Elucidation of the Hormonal, Genetic and Epigenetic Mechanismsâ€, the study is being led by Shalender Bhasin, M.D., Director of the Research Program in Men’s Health: Aging and Metabolism at BWH.
The objective of this systematic investigation will be to determine whether there is a syndromic constellation of signs, symptoms and hormone levels that characterize PFS.
PFS has been reported to occur in men who have taken the prescription drug finasteride to treat hair loss (under the brand name Propecia and generics), or enlarged prostates (Proscar and generics).
Reported symptoms include loss of libido, erectile dysfunction, Peyronie’s disease, penile shrinkage, gynecomastia, muscle atrophy, cognitive impairment, severely dry skin, and depression. The condition often has a life-altering impact on victims and their families, such as job loss and the breakup of marriages and romantic relationships, while also being linked to suicides.
Methods of the BWH study are as follows:

  1. Evaluate sexual, psychological and cognitive function
  2. Assess hormone levels and metabolic parameters
  3. Identify epigenetic interactions with the androgen receptor (AR) and gene expression of AR-dependent genes
  4. Perform magnetic resonance imaging of the brain in a group of subjects consisting of PFS patients, former asymptomatic users of finasteride for male pattern hair loss, and age matched controls
The PFS Foundation believes this study will:

  • Help establish PFS as a bona fide condition
  • Help uncover some of the underlying biological mechanisms of PFS
  • Elucidate the hormonal, genetic and epigenetic mechanisms of PFS
  • Provide leads for the development of mechanism-specific therapeutic strategies
Patient recruitment is currently underway. Prospective patients may call Allen Papazian at (617)525-9197 to determine if they are eligible.
“This study promises to be an important step in our progress toward better understanding post-finasteride syndrome,†said PFS Foundation CEO Dr. John Santmann.

On April 11, 2012, the Food and Drug Administration ordered drug manufacturer Merck to revise the labeling on Propecia to reflect mounting evidence that it can cause persistent sexual dysfunction. Of the 421 Propecia-related sexual dysfunction cases reviewed by the FDA in its probe, 14 percent lasted longer than three months after patients quit the drug.
About Dr. Shalender Bhasin
Dr. Bhasin is an internationally recognized reproductive endocrinologist with expertise in androgen biology who is director of the Men’s Health Unit, Division of Endocrinology, Diabetes & Metabolism in the Department of Internal Medicine at BWH. He has served in many national and international leadership positions, including Chair of the American Board of Internal Medicine: Endocrinology & Metabolism Subspecialty Board, Chair of the Endocrine Society’s Expert Panel on Androgen Deficiencies in Men, and Associate Editor of the Journal of Clinical Endocrinology & Metabolism.

If you dont want to take finasteride thats fair enough its your decision, but why insist on posting at every opportunity you get about something you have absolutely no experience of.

I feel sorry for the guys who listen to you and dont start finasteride when it could have really helped them without any sides what so ever. The fact is side effects really are rare and when they do occur they normally go away when you stop the drug.

You can choose to believe what you want and in the meantime continue lose hair but I choose to take finasteride and based on my personal experience (something which you dont have) it is relatively safe and clearly the most proven treatment that we have.

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I used it for about two years. It resulted in very weak wood and watery semen. Furthermore it gave me brain fog. The libido returned within a few months upon after cessatation but the brain fog lasted considerably longer. Since 5-ar is important for the metabolism of quite some goodies in the brain, I guess some people are sensitive some are not. When you don't experience the sides it's easy to discount everybody else's experience as placebo. I don't see whole boards being setup for people getting low libido from banana's, you connect the dots and don't go ape**** on the people giving you their honest experience.

I don't discount everybody else's experience as placebo, sides are real but the reality is they are rare. I guess you were just one of the unlucky ones.

I'd encourage more people to post like yourself who have given finasteride a fair try and want share their experiences whether they are good or bad.

However what does wind me up and im sure other members too are people that add to the scaremongering without having even tried the drug for themselves.
 

xRedStaRx

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Side effects from finasteride are real, but rare.

Yes you can and should get some side effects from the start, but it normalizes more often than not with time. I've personally had physical side effects from the first few hours after starting, not placebo. But all's good now.
 

viet nom nom

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The control groups get sides at almost the same rate as the finasteride groups. I am a psychologist and have been meaning to post on this issue. Call me lazy.
 

thedarkcolor

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It's so upsetting to read **** like this with people joking about side effects.

I'm 24. I was 23 when I took finasteride at 1.25 mg for about 8 days earlier this year. The first day I took it, I got testicular tightness and prostate pains. By day two I got breast pains in conjunction with testicle pains. By day 8 I wasn't able to sleep, and I got terrible brain fog....couldn't think straight and had to be admitted to the ER twice in the span of 3 days. It ****ed me up so bad. I had PFS for about a month afterwards, with weird armpit pains and horrible brainfog which almost cost me my job. When I started taking the medication I didn't even think about side effects, I knew of them but it wasn't something I was fixated on or was "expecting" or paranoid about. One thing though, is that I've always been straight-edge and I'm very thin and in the past medications like NyQuil and other chemicals really hit me hard and have a pretty strong effect. I think that's just how I'm genetically put together.

That was back in March and I'm pretty much 100% recovered now. I've since started 5% minoxidil and taking 1,800 mg of Saw Palmetto daily, which I don't think has helped at all and I'm losing hair pretty fast.

The sad thing is, I want to keep what hair I have so bad I'm considering going back to a doctor and asking for generic 1mg finasteride and cutting that up into 4ths or halves or something. I'm just thinking of, 1.25mg did a number on me in such a short span of time, will .25 or .5 mg really be any different?

That's just one person's story. Side effects are real and should be taken seriously. Not a shill or a fear advocated, yadda yadda...I'm even considering trying again after I developed short term PFS!
 

Aesthetic

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It's so upsetting to read **** like this with people joking about side effects.

I'm 24. I was 23 when I took finasteride at 1.25 mg for about 8 days earlier this year. The first day I took it, I got testicular tightness and prostate pains. By day two I got breast pains in conjunction with testicle pains. By day 8 I wasn't able to sleep, and I got terrible brain fog....couldn't think straight and had to be admitted to the ER twice in the span of 3 days. It ****ed me up so bad. I had PFS for about a month afterwards, with weird armpit pains and horrible brainfog which almost cost me my job. When I started taking the medication I didn't even think about side effects, I knew of them but it wasn't something I was fixated on or was "expecting" or paranoid about. One thing though, is that I've always been straight-edge and I'm very thin and in the past medications like NyQuil and other chemicals really hit me hard and have a pretty strong effect. I think that's just how I'm genetically put together.

That was back in March and I'm pretty much 100% recovered now. I've since started 5% minoxidil and taking 1,800 mg of Saw Palmetto daily, which I don't think has helped at all and I'm losing hair pretty fast.

The sad thing is, I want to keep what hair I have so bad I'm considering going back to a doctor and asking for generic 1mg finasteride and cutting that up into 4ths or halves or something. I'm just thinking of, 1.25mg did a number on me in such a short span of time, will .25 or .5 mg really be any different?

That's just one person's story. Side effects are real and should be taken seriously. Not a shill or a fear advocated, yadda yadda...I'm even considering trying again after I developed short term PFS!

.............


maybe u were taking fake finasteride and it was sommething else
 

thedarkcolor

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Yes, I got fake finasteride from a prescription my doctor gave me which I filled at Target's Pharmacy. And then out of nowhere I developed side effects that finasteride's warning label lists after I began taking the medication.

I wish I didn't get sides. I want to take finasteride to save my hair but after what I went through the first time, I'm still weighing whether it's worth it to try a second time.
 

ThereIWas

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I talked about this with my doctor. He said there is likely not a link: It's just a case of people who would have these problems anyway blaming them on the drug.

Correlation =/= causation.
 

xRedStaRx

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I talked about this with my doctor. He said there is likely not a link: It's just a case of people who would have these problems anyway blaming them on the drug.

Correlation =/= causation.

There is a weak correlation on a large sample size. We can't rule it out either.
 

viet nom nom

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Yeah, but that is key. Weak correlation, large sample, higher probablity that you convinced youself of the sides than they are an issue. I beat myself up on it for a long time begore trying, and now that I'm on it, it's like "that's it?!???!".

Too many bad vibes in tha internets.
 

xRedStaRx

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Yeah, but that is key. Weak correlation, large sample, higher probablity that you convinced youself of the sides than they are an issue. I beat myself up on it for a long time begore trying, and now that I'm on it, it's like "that's it?!???!".

Too many bad vibes in tha internets.

Out of 10000 people on finasteride and 10000 on placebo, there was a statistically significant difference between sexual symptom reports. Even though they were not huge, only about a 2-fold increase of occurrence.

Finasteride can give you sexual side effects, but nocebo can just as much. It would be clearly stupid to say finasteride is comparable to placebo.
 

viet nom nom

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You are correct, that would be stupid. What would not be stupid is saying that placebo is comparable to finasteride, in terms of side effects. There might be a statistically significant difference, but when we speak of effect size, the medical effect is appreciably smaller than that which is attributable to the effect of being given a pill that ostensibly causes erectile disfunction.

This is what people need to know going into taking this drug. Unfortunately, scary stories trump data.
 

sammo123

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I'd just like to chime in here…. Been taking brand name Propecia for about 6-7 years now so I'd like to hope I know a bit about it. ;-)

Remembering back...In the first 6 months I had massive brain fog that would kick in a few hours after taking it. For all of you that don't know, brain fog is kind of like a hazy feeling that makes you uncomfortable, for me irritated, stressed too and overwhelmed (hard to describe). It's real. I used to take it in the mornings and by lunch time at my job I'd often feel quite foggy. Towards the end of the day I'd find myself feeling good then realising it had worn off. It's a hard thing to have self awareness of this state and sometimes you just find yourself thinking things suck… But then realise, oh it could be the fog. I then started taking it before bed but also reducing to 0.5 daily. This seemed to make it better because I think the fog was hitting in my sleep.

A year or so later I eventually upped to 1.0 and the fog didn't seem to reappear. Or at least I stopped noticing it. Only looking at this thread now made me think back to then. I also did actually get sharp pains / aches occasionally when initially starting on the prostate area or urinal area. These eventually subsided somewhere in the process.

Over the years since taking finasteride my volume of ejaculate has definitely reduced and ever since early days starting thin it definitely changed to a more watery texture.

People should be open to sides but it's dangerous to be expecting or paranoid of them in the same way. I'm a firm believer that everything we do to our bodies has an effect and I don't truly believe finasteride can be a good thing for me to take for so long, so we'll just have to wait and see what happens in the longer term…..
 

mr.patches

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Yeah, but that is key. Weak correlation, large sample, higher probablity that you convinced youself of the sides than they are an issue. I beat myself up on it for a long time begore trying, and now that I'm on it, it's like "that's it?!???!".

Too many bad vibes in tha internets.

http://www.youtube.com/watch?v=K1pb4RSGe_E

Two retarded hosts that need drama in their talk show, plus a dude who has ABSOLUTELY NO male pattern baldness at age thirty something and is being paid plenty for talking sh*t about Propecia, not even finasteride.

Why all the hate? Because for some twisted reason we ought to be bald. If we fight it, then we are reckless superficial f*ggots that can't handle life. Since I started treatment, my confidence went through the roof and I feel a lot better than I ever felt doing sh*t. The regimen did that alone, all you need to do is pop a pill everyday and take care of yourself, choose a good diet (maybe adding extra supplements) and stay fit.
 

fml

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Oh okay, you've convinced me.


Like anyone cares if you are convinced or not. Nobody is here to convince you of anything. Do want you want; its your hair. Good luck with that.

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I have read complaints of guys who got sides from just touching the pill.


Thats nothing. I have read about guys who got finasteride related sides while still in the womb, just from the thought that they might get male pattern baldness and have to take it. Its dangerous stuff that finasteride. It can make penises shrivel up so much that they invert and become vaginas. It can even make them just drop off.
 
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