3alpha-hydroxysteroid reductase and hair loss - a theory from Tressless

[joaopassos4444]

You guys have been a bit harsh on me. But it's fine, no hard feelings, besides we're all on the same boat.

 

[BetaBoy]

Ohh sh*t man!! Imagine that the best growth stimulant we have has been accidentaly discovered by a bozo researching blood pressur (wich isn't even good for blood pressure), Imagine the best 5ar inhibitor being discovered by a bozo studying enlarged prostates. And now imagine a bozo on reddit connecting the dots. f*** this is hard times to be one of the hundreds of thousands of hair loss researchers. LOL

Are we really calling researchers that do hard original scientific work bozos now? These people literally travel to the tropics, document a unique super rare genetic disorder among a local populace in a remote village, diagnose said disorder and in doing so make 2 important discoveries concerning the prostate and MPΒ. The parallels you are drawing between these individuals and yourself maybe one of the reasons why a lot of people are struggling to take you and your theory seriously.

 

[max.912]

I hate the arrogance here. Like this HairLossTalk.com forum would be something like a super squat of high level researchers being able to debunk anything proudly leaded by their cocaine stuffed nobel prize aspirant Kevin Mann.
Happy broscience day to you all !!1! lmao

 

[pegasus2]

I hate the arrogance here. Like this HairLossTalk.com forum would be something like a super squat of high level researchers being able to debunk anything proudly leaded by their cocaine stuffed nobel prize aspirant Kevin Mann.
Happy broscience day to you all !!1! lmao

That's some serious irony.

 

[Armando Jose]

Testing sebum (DHT ) in scalp hair of childrens can open a new view on common hair loss aka Androgenetic Alopecia.

example: in hair not washed at least one day in children between 6 and 8 years of age, and without the need to travel to the Dominican Republic

 

[Eazy12]

I have a theory, male pattern baldness is caused by a giant Norwood Reaper which orbits Mars and shoots DHT amplifying rays down to Earth.
Wut you want proof? No idiot, the onus is on YOU to disprove me.
Did I mention the Reaper is the KrYpToNiTe? My theory is 100% sound but I have zero evidence and the studies I'm basing my theory on are too complicated for my high school level brain,which prefers to be occupied playing Minecraft and Fortnite.

 

[Hutnubu]

I don't get why some of you have to ridiculise one user with a theory. It almost looks as if he attacked you personally. I get that some of you are researchin aswell and trying stuff out but He just posted a theory to let more people know what he is studying and mostly to get some scientific feedback. I would love if this thread would be about scientific facts proving or disproving that theory

 

[Hutnubu]

Science:
the intellectual and practical activity encompassing the systematic study of the structure and behaviour of the physical and natural world through observation and experiment

He has no legitimate observations or experiments showing how this stuff works to grow hair on scalps. The onus is on him to systematically provide legitimate observations and experiments to discuss.

thanks for the nice quote. i never said that he is a scientific. And you are wrong in thinking that its up to him to prove that the theory is right. He doesn't owe you anything. He just shared what his thoughts are. but anyway this thread should be about 3alpha-hydroxysteroid reductase (proving its usefullness or it's uselessness) and less about mocking a random guy. Don't you agree?

 

[pegasus2]

thanks for the nice quote. i never said that he is a scientific. And you are wrong in thinking that its up to him to prove that the theory is right. He doesn't owe you anything. He just shared what his thoughts are. but anyway this thread should be about 3alpha-hydroxysteroid reductase (proving its usefullness or it's uselessness) and less about mocking a random guy. Don't you agree?

The thread should be about something that doesn't exist? You didn't even watch the video or you wouldn't keep calling it that. You're reddit dude, aren't you?

 

[feelsbad]

You didn't even watch the video or you wouldn't keep calling it that.

In fairness, I don't know how anyone could make it through an entire Kevin Mann video

 

[fugged]

im too tired to know exactly the deal here, but if he's somehow trying to boost sales of garbage that is already out there by spreading this because he knows hundreds of thousands of desperate people will read it and ultimately purchase said supplements, and he will somehow profit in some roundabout way, he deserves to be treated as such, but if he is genuinely trying to figure something out, he deserves civility. IMO.

 

[fugged]

The Kevin video guy is claiming that circulation or "bludflow" isn't the deal with hair loss.. but weren't we recently discussing taking Cialis or something to that effect, and that anything that increases circulation should automatically help? I truly feel like my scalp, where worst, has little sensation, like it is blood starved.. Anesthetics work in this way- they shut blood flow to the nerves therefore stopping both pain and bleeding- the latter, and usually the former, being necessary in a hair transplant surgery. Hence the risk of shock loss in transplants. The healthier follicles are like being held underwater if you will, they basically starve for blood flow (oxygen?) and may die from the anesthetic. Source: personal conversation w Dr Rassman.

 

[BetaBoy]

Anesthetics work in this way- they shut blood flow to the nerves therefore stopping both pain and bleeding

If anaesthetics worked by shutting down blood flow you'd be dead. Anasthetics work by interferring/suppressing signalling within the nervous system.

 

[fugged]

If anaesthetics worked by shutting down blood flow you'd be dead. Anasthetics work by interferring/suppressing signalling within the nervous system.

No, Im talking about local not general. Again, Im quoting a surgeon directly.

 

[BetaBoy]

No, Im talking about local not general. Again, Im quoting a surgeon directly.

Then you are either misquoting or your source is wrong. GA and LA work in much the same way, many anaesthetics actually cause vasodilation, i.e., cocaine, causing blood flow to increase, this can be quite dangerous so typically anaesthetics are mixed with vasoconstrictors, i.e., epinephrine which helps to keeps an LA local

 

[fugged]

No, Im talking about local not general. Again, Im quoting a surgeon directly.

Then im probably misquoting or he was simplifying the conversation by including epinephrine, as we all know scalps bleed profusely and one could imagine someone trying to have a transplant surgery without the vasoconstrictors.. would be a mess.

More to the point, if the *vasoconstrictors* can and do cause shock loss from temporary total starvation of circulation.. then why is the Kevin guy so convinced that "bludflow" is irrelevant???? If thats wrong is he really so astute as to disprove the theory? Im not defending the theory just asking.

 

[BetaBoy]

Then im probably misquoting or he was simplifying the conversation by including epinephrine, as we all know scalps bleed profusely and one could imagine someone trying to have a transplant surgery without the vasoconstrictors.. would be a mess.

More to the point, if the *vasoconstrictors* can and do cause shock loss from temporary total starvation of circulation.. then why is the Kevin guy so convinced that "bludflow" is irrelevant???? If thats wrong is he really so astute as to disprove the theory? Im not defending the theory just asking.

I'm sorry where are you getting the vasoconstrictors cause shock loss idea from? Shock loss in hair transplants is caused by the unavoidable trauma a grafts experiences during extraction and relocation.

 

[fugged]

Dr Rassman was very specific here.. that one would suffer shock loss to follicles that *are existing* NOT transplanted- in other words, you may lose hair you already have due to the vasoconstriction (that I understood as anesthetic). Im sure it also applies to grafts, but he was extremely clear on this point. That an attempt to add grafts into a scalp that had a decent amount of hair could absolutely make things worse than before because of the temporary but significant starvation of blood during the procedure, and he said that he would not do anything on me (not that I was really considering it) because he felt the risk of this was too high. I misunderstood his combination of anesthetic and epinephrine (which I know is a common cocktail), but he was extremely clear here.

 

[fugged]

do whatever you want, but some advice - don't get sucked into debating yet another person with zero references or personal experience, especially over someone else's theory. "my presentation of what my infallible expert said to discredit someone else's infallible expert"
it would be different if Rassman was presenting his clinical experience personally.

it is not clear what a one off vasoconstriction would do.

Hair Loss and Scalp Cooling (mascc.org)
Chemotherapy-induced hair loss is a common and distressing side effect of cancer therapy and presents a major supportive care challenge. Scalp cooling has been shown to be effective for preventing hair loss for many patients. Although the mechanism for its effect is not certain, it is hypothesized that cooling of the scalp causes cutaneous vasoconstriction, which reduces blood flow to the hair follicles thereby as well as the uptake of chemotherapeutic agents.

ongoing vasoconstriction might be detrimental

Subcutaneous blood flow in early male pattern baldness - PubMed (nih.gov)
A reduced nutritive blood flow to the hair follicles might be a significant event in the pathogenesis of early male pattern baldness.

I've experimented/ing with nitrites/trates and PDE5 inhibitors, until i get full coverage band boy hair, i'm not claiming how or if anything works...

but i'm open to novel approaches if op has something coherent to share...

Actually, I cited my source; a long in person conversation with a world-renowned expert with decades in the field. And I think Beta and I were having a conversation, not a debate. He corrected my misunderstanding about vasoconstriction vs anesthetics, and he even managed to be polite. Apparently you feel Dr. Rassman's thousands of hours preforming surgeries is dubious compared to your hunchy anecdotal wisdom but Ill take his word for it.

 

[JaneyElizabeth]

do whatever you want, but some advice - don't get sucked into debating yet another person with zero references or personal experience, especially over someone else's theory. "my presentation of what my infallible expert said to discredit someone else's infallible expert"
it would be different if Rassman was presenting his clinical experience personally.

it is not clear what a one off vasoconstriction would do.

Hair Loss and Scalp Cooling (mascc.org)
Chemotherapy-induced hair loss is a common and distressing side effect of cancer therapy and presents a major supportive care challenge. Scalp cooling has been shown to be effective for preventing hair loss for many patients. Although the mechanism for its effect is not certain, it is hypothesized that cooling of the scalp causes cutaneous vasoconstriction, which reduces blood flow to the hair follicles thereby as well as the uptake of chemotherapeutic agents.

ongoing vasoconstriction might be detrimental

Subcutaneous blood flow in early male pattern baldness - PubMed (nih.gov)
A reduced nutritive blood flow to the hair follicles might be a significant event in the pathogenesis of early male pattern baldness.

I've experimented/ing with nitrites/trates and PDE5 inhibitors, until i get full coverage band boy hair, i'm not claiming how or if anything works...

but i'm open to novel approaches if op has something coherent to share...

Only one thing regrows hair like we had in the days of yore but I am not saying what lest the bullies harangue me for promoting being a sissy to regrow hair.