maverickf-14 said:its in german ?? im just started on .25, 3 weeks in all is good so far ! but i would like to know if anyone has had good results from .25??
Wuffer said:Has anyone considered taking .25mg every 12 hours? I cant remember who posted it, but in about 14-16 hours of taking .25mg, the level of finasteride drops below effective levels, leaving roughly 8 hours out of your day with effectively no dht reduction.
I never thought I was going to say this to you, but you're wrong. Finasteride and dutasteride aren't suicide inhibitors, which means that once the serum concentration drops below a certain point, most of the enzymes are free to produce DHT. The body produces DHT mainly where it's needed, but when all the receptors in that area are saturated, the excessive DHT travels throughout your body until it finds something to bind to. Serum concentration of DHT is suppressed for more than a week after 1 mg finasteride, if I remember correctly, but don't confuse it with local DHT availability. 0.05 mg finasteride is as effective as larger doses, but obviously not for as long. Since half life is 6 hours, 0.25 mg twice a day, 12 hours a part, is theoretically as effective as 1 mg a day.Bryan said:Wuffer said:Has anyone considered taking .25mg every 12 hours? I cant remember who posted it, but in about 14-16 hours of taking .25mg, the level of finasteride drops below effective levels, leaving roughly 8 hours out of your day with effectively no dht reduction.
Baloney. Let me repeat that: BALONEY. B-A-L-O-N-E-Y. As I've said over and over and over and over on these hairloss sites too many times to count, it takes a week or two for levels of DHT to get back to "normal" after the last dose of finasteride! The reason for that is that the enzyme that actually synthesizes DHT from testosterone (5a-reductase type II) itself takes a pretty long time to be synthesized.
So here's what basically happens: finasteride is an irreversible inhibitor of 5a-reductase type II. When you knock it out with finasteride (or dutasteride, for that matter), it's GONE. Kaput. Fini. Sayonara. Your body has to wait for more 5a-reductase type II to be synthesized, just to replace what used to be there. So DHT takes a while to be freshly produced, too (a week or two)!
Enden said:I never thought I was going to say this to you, but you're wrong. Finasteride and dutasteride aren't suicide inhibitors, which means that once the serum concentration drops below a certain point, most of the enzymes are free to produce DHT.
Enden said:The body produces DHT mainly where it's needed, but when all the receptors in that area are saturated, the excessive DHT travels throughout your body until it finds something to bind to.
Enden said:Serum concentration of DHT is suppressed for more than a week after 1 mg finasteride, if I remember correctly, but don't confuse it with local DHT availability.
Enden said:0.05 mg finasteride is as effective as larger doses, but obviously not for as long. Since half life is 6 hours, 0.25 mg twice a day, 12 hours a part, is theoretically as effective as 1 mg a day.
Finasteride only suppresses enzymes efficiently for a given time, according to the half life, and when the time is out, those enzymes will begin producing DHT again. That DHT will bind to the receptors which are close, and only when all the receptors in that area are saturated, DHT will move on, and the serum concentration raises.Bryan said:I'm not sure what you mean by that.Enden said:Serum concentration of DHT is suppressed for more than a week after 1 mg finasteride, if I remember correctly, but don't confuse it with local DHT availability.
CLINICAL PHARMACOLOGY
Finasteride is a competitive and specific inhibitor of Type II 5?-reductase (...)
Enden said:Thery're not marketed as suicide inhibitors...
Enden said:...and I've never heard anyone claim that they're SI's, before you.
Enden said:I don't know what an auto- or paracrine hormone is...
Enden said:Finasteride only suppresses enzymes efficiently for a given time, according to the half life, and when the time is out, those enzymes will begin producing DHT again.
Enden said:That DHT will bind to the receptors which are close, and only when all the receptors in that area are saturated, DHT will move on, and the serum concentration raises.
Enden said:By the definition, I think I've been more f***ed by finasteride, than you.
Enden said:If what you said was true, people wouldn't notice increased shedding if the daily dose is cut.
Enden said:1 mg finasteride a day, wouldn't be superior to 0.2 mg a day, in terms of visible results.
Enden said:I will agree that DHT is mainly paracrine hormone, but it obviously has endocrine properties. When all the receptors in the local area are saturated, it'll travel around your body, and it counters estrogen and its effects.
Enden said:It's stated that finasteride is a competitive inhibitor, and that 0.05 mg is the smallest effective dose regarding hair loss, and you say it's not?