Background Female pattern hair loss (FPHL), also known as female androgenic alopecia, is a common dermatological disorder with a multifactorial pathogenesis. Oxidative status has been implicated in the pathogenesis of several skin diseases, including FPHL.
Aim This study was aimed to investigate...
Effects of dihydrotestosterone on rat dermal papilla cells in vitro
DHT also induced the phosphorylation and nuclear translocation of heat shock protein 27 (HSP27). Moreover, DHT decreased the levels of total and nuclear β-catenin, an important regulator of hair growth and proliferation, while...
Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts
AR transcription activity was increased by about 250% with DHT, but significantly...
It seems that the general consensus is a decrease of serum PON1 enzyme activities is directly associated with systematic oxidative stress and chronic inflammation. Same conclusion on every papers/studies.
example below.. I can carry on forever with so many studies.
"Genetic deletion of PON1...
Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.
Pharmaceutical drugs found to increase PON1 activity/expression in animals or Humans
The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases
Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown...
Androgenetic alopecia (Androgenetic Alopecia) is a common stressful form of hair loss caused by androgen excess, genetic factors, and exposure to oxidative stress (OS) with the formation of reactive oxygen species (ROS). Paraoxonase 1 (PON1) is an enzyme synthesized in the liver bound to...
Early onset androgenic alopecia as the male phenotypic equivalent of polycystic ovarian syndrome is associated in high oxidative stress.
Oxidative stress in androgenetic alopecia
B E Prie 1, L Iosif 2, I Tivig 2, I Stoian 2, C Giurcaneanu 3
Free PMC article
Rationale:Androgenetic alopecia is not considered a life threatening disease but can have serious impacts on...