Recent content by Spice_Lord

A combination of nortriptyline and desloratidine was shown to decrease the amount of IL-17 produced in mice. PMID 21696713 Also the active form of vitamin D has been shown to severely impair IL-17 production

Lol yes, it seems we can never win. It was an interesting study, genistein showed up as an agent that can induce the second half of the required response for hair growth but not the initial step needed to spur the process. I find it interesting that yohimbine is on both lists but the author...

From the study, One of the proposed agents, fluphenazine (from the d 2 signature) actually induced hair growth in vivo (ED50: 2 mM for single application), and the subsequent application of 5 mM iloprost (from the d 4 signature) significantly enhanced the hair-growth effect of fluphenazine...

You are correct this is going to have piss poor absorption, skin is built to keep out peptides. If this dissolved in ethanol best option would be to make ethosomes as these do not require a rotary evaporator and can be reduced in size through extrusion with about $3 worth of syringes and a $0.99...

https://www.nature.com/articles/s41598-017-02419-3 Looks like there could be huge benefits of taking this topically. Having an agent that could potentially activate the Wnt pathway with a safety profile so we know we won't get cancer? Could be huge. Might not dye skin too bad...

If you google 30% minoxidil you'll figure out it is most likely a scam if in solution or an ineffective product in a cream suspension. The point isn't to search google for the elusive magic minoxidil crystals, when someone right here is claiming to be using a product successfully, and yet...

This is actually quite interesting. Methylene blue is very similar in structure to Gallocyanin which is an inhibitor of Dkk-1 (implicated in androgenic alopecia). There may be more to this, the problem is it will dye your skin.

Go look up solubility data for Minoxidil, you'll find that it isn't able to solubilize at levels as high as 300 mg/mL, not even close. You still never answered what vehicle it is dissolved in, so there is no point in arguing anymore because you cannot produce any evidence. Whatever 30% product...

Crystallized minoxidil? This makes no sense at all. What's the vehicle it's being dissolved in? That's all that matters.

I'm actually surprised there is zero experimentation with a topical vitamin D activated analog (cheapest option calcitriol). Shows some decent results in Areata Alopecia patients, helps other issues like psoriasis, and other studies show it can help induce hair folliculogenesis.

This is just a straight up lie. You cannot even dissolve 300 mg of minoxidil in 1 mL of anything that I am aware of. Also, this is extremely dangerous to even apply because if a fraction of this gets absorbed systemically you are looking at some serious side effects and potentially dangerously...

Oh definitely, I would probably always dermastamp whenever applying a liposomal preparation because I believe most liposomal preparations have a tendency to stay between the epidermal and dermal layers of the skin, or even stay within the stratum corneum. The only problem with larger size...

The one I linked there is 0.22 mcm which is 220 nm. You can find them in 200, 100, and 50 nanometers sizes, although I think for the 50 nm (0.05 mcm) size you would have to buy those in a pack of 100. With the ultrasonic bath, I don't think you would reach sizes below 100 nm either, the energy...

Holy christ, probe or bath? Yes extruder is the way to go, there is no difference between extrusion and sonification. As far as buying an extruder, you can get by with ordering a couple syringes and a syringe filter such as these...

I thought the theory was that DHT cannabolized the fat and eroded the healthy hair environment, or something like that. Why doesn't someone test building back a subcutaneous fat foundation if they believe in this theory?