Recent content by InBeforeTheCure

  1. InBeforeTheCure

    The Group Buy to End All Group Buys: Twist1 Inhibitor

    Just checked - Twist1 expression is 9 times higher than Twist2 in human DP. Could be similar to the mice where Twist2 expression drops a lot in the DP after HF development.
  2. InBeforeTheCure

    HDAC 4 Is most likely the cause of our suffering

    Yeah, in his case the one functional copy is apparently enough to avoid craniosynostosis. Differences are due to genetic background effects, I guess.
  3. InBeforeTheCure

    Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells

    Take with a grain of salt since DPCs in vitro lose a lot of their characteristics away from their in vivo environment and become more like regular dermal fibroblasts. https://link.springer.com/article/10.1186/s12863-021-01018-6 Full list of genes here.
  4. InBeforeTheCure

    HDAC 4 Is most likely the cause of our suffering

    Found a balding guy with a deletion in TWIST1. (source)
  5. InBeforeTheCure

    The Group Buy to End All Group Buys: Twist1 Inhibitor

    Actually, Saethre-Chotzen is autosomal dominant, so there's still a chance of going full Wookie I guess.
  6. InBeforeTheCure

    The Group Buy to End All Group Buys: Twist1 Inhibitor

    That mop on the right is a Fgfr1/Fgfr2 DP-specific double knockout, not a Twist1 knockout. ;) https://www.nature.com/articles/s41467-020-18643-x
  7. InBeforeTheCure

    The Group Buy to End All Group Buys: Twist1 Inhibitor

    People with Saethre-Chotzen syndrome (TWIST1 loss of function) don't have any hypertrichosis whatsoever AFAIK. Compared to mice maybe there's compensation by TWIST2 or other families of transcription factors that pushes the HFs into catagen phase. Judging by the pictures, even the short hairs on...
  8. InBeforeTheCure

    HDAC 4 Is most likely the cause of our suffering

    HDAC9 and TWIST1 are the two candidate genes at that locus, but again TWIST1 IMO is more likely the causal gene for basically the same reasons. ;) Knocking out Twist1 in mice -> infinite anagen. (source)
  9. InBeforeTheCure

    HDAC 4 Is most likely the cause of our suffering

    The causal gene is probably not HDAC4. More likely TWIST2 due to other Androgenetic Alopecia-associated variants around classic TWIST binding factors TCF4 and TCF12 and the known important role of TWIST2 in hair biology. It shuts down hair inductivity in dermal cells by recruiting HDAC2 to critical hair-inducing...
  10. InBeforeTheCure

    New Studies Show Vit D Implicated In Hair Loss And Calcipotriol

    Exactly. Look at the top SNP associated with vitamin D level, which is this one. It's also associated with counts of certain immune system cells, height, etc. but has zero association with balding. Look at more of these variants - again no balding. The association between vitamin D measurement...
  11. InBeforeTheCure

    Samumed sm04554. Only drug on phase 3

    You should include only 100% matches. You can run gene ontology enrichment analysis on this site and download the results. I found, using an absolute log2 fold change of at least 0.5, 362 biological processes enriched in the opposite direction in the E2 vs. A.G.A. datasets compared to only 174...
  12. InBeforeTheCure

    Samumed sm04554. Only drug on phase 3

    You can try these to start. Go to the NCBI site and search under GEO datasets for more. Differentially expressed genes don't replicate well at all between studies though. It's probably better to compare gene ontology and transcription factor target enrichment.
  13. InBeforeTheCure

    Samumed sm04554. Only drug on phase 3

    They tested only E2. I don't know what we could extrapolate to other estrogens.
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